A high flux neutron source based on a vacuum-insulated tandem accelerator (VITA) and a lithium target has been proposed and developed at the Budker Institute of Nuclear Physics in Novosibirsk, Russia. We describe VITA which provides a dc proton/deuteron beam with an energy within a range of 0.6–2.3 MeV with a current from 1 nA to 10 mA. VITA is also capable of producing α-particles through the 7Li(p,α)α and 11B(p,α) α α reactions, 478 keV photons through the 7Li(p,p ′ γ)7Li reaction and positrons through the 19F(p,e+e−)16O reaction. We present several applications of this source: boron neutron capture therapy, nuclear cross sections determination, lithium target study, radiation blistering of metals during proton implantation and the radiation testing of promising materials.