We present a detailed analysis and interpretation of the high-mass binary V380 Cyg, based on high-precision space photometry gathered with the Kepler space mission as well as high-resolution ground-based spectroscopy obtained with the HERMES spectrograph attached to the 1.2m Mercator telescope. We derive a precise orbital solution and the full physical properties of the system, including dynamical component mass estimates of 11.43+/-0.19 and 7.00+/-0.14 solar masses for the primary and secondary, respectively. Our frequency analysis reveals the rotation frequency of the primary in both the photometric and spectroscopic data and additional low-amplitude stochastic variability at low frequency in the space photometry with characteristics that are compatible with recent theoretical predictions for gravity-mode oscillations excited either by the convective core or by sub-surface convective layers. Doppler Imaging analysis of the silicon lines of the primary suggests the presence of two high-contrast stellar surface abundance spots which are located either at the same latitude or longitude. Comparison of the observed properties of the binary with present-day single-star evolutionary models shows that the latter are inadequate and lack a serious amount of near-core mixing.
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