Uvaria Narum Research Articles

Green Synthesis of Silver Nanoparticles Using the Leaf Extract of the Medicinal Plant, Uvaria narum and Its Antibacterial, Antiangiogenic, Anticancer and Catalytic Properties.

Silver nanoparticles (AgNPs) made by green synthesis offer a variety of biochemical properties and are an excellent alternative to traditional medications due to their low cost. In the current study, we synthesised AgNPs from the leaf extract of the medicinal plant Uvaria narum, commonly called narumpanal. The nanoparticles were characterised by ultraviolet-visible (UV-Vis) spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and transmission electron microscopy (TEM). SEM analysis showed AgNPs are highly crystalline and spherical with an average diameter of 7.13 nm. The outstanding catalytic activity of AgNPs was demonstrated by employing the reduction of 4-nitrophenol to 4-aminophenol. The AgNPs showed antiangiogenic activity in the chick chorioallantoic membrane (CAM) assay. AgNPs demonstrated anticancer activity against Dalton's lymphoma ascites cells (DLA cells) in trypan blue assay and cytotoxicity against three fish cell lines: Oreochromis niloticus liver (onlL; National Repository of Fish Cell Lines, India (NRFC) Accession number-NRFC052) cells, Cyprinus carpio koi fin (CCKF; NRFC Accession number-NRFC007) cells and Cyprinus carpio gill (CyCKG; NRFC Accession number-NRFC064). Furthermore, the AgNPs demonstrated their ability to inhibit pathogenic microorganisms, Staphylococcus aureus, and Escherichia coli. The results from the study displayed green synthesised AgNPs exhibit antiangiogenic activity, cytotoxicity, antimicrobial and catalytic properties, which are crucial characteristics of a molecule with excellent clinical applications.

Uvaria narum

This datasheet on Uvaria narum covers Identity, Distribution.

Study of antidiabetic properties of Uvaria narum leaf extract through glucose uptake and glucose transporter 4 expression studies in 3T3L1 cell line model

Background: Uvaria narum (UN) is known to have antipyretic, antimicrobial, anti-inflammatory and antimalarial properties. The antidiabetic properties of UN remains unexplored. The current study has been aimed at understanding the antidiabetic property of UN extract on an in vitro model using 3T3-L1 cell line. Methods: Methanolic extract of UN was prepared, and its cytotoxic effect on 3T3-L1 cells was assessed. Glucose uptake and glucose transporter 4 (GLUT4) translocation in 3T3-L1 cell line on treatment with the extract was evaluated against a standard drug, metformin. α-glucosidase and α-amylase inhibition activities of the extract were also assayed with acarbose as the standard drug. Results: Treatment with UN extract had no cytotoxic effect on the cells. UN extract showed a good percentage inhibition of α-amylase and α-glucosidase activities. UN extract showed 71.31% inhibition and the control drug Acarbose exhibited 88.54% inhibition in α-amylase activity. Furthermore, the extract showed 79.11% inhibition when Acarbose exhibited 87.35% inhibition in α-glucosidase activity. IC50values were also determined. Further, on treatment with the extract, 75.49% of 3T3-L1 cells took up glucose and 70.67% had GLUT4 expression. Conclusion: UN extract enhances glucose uptake and GLUT4 expression, inhibits α-amylase and α-glucosidase activities, thereby demonstrating the antidiabetic properties in vitro.

A new antifungal benzoic acid ester from Uvaria narum

Uvaria narum has been used for gastrointestinal problems, jaundice, fever and skin diseases in traditional and ethnomedical practices. Our preliminary antifungal screening of various leaf extracts of U. narum revealed very good antifungal activity for its acetone extract. Active principle of U. narum leaf acetone extract was isolated by bioactivity-guided fractionation and characterised as a new molecule, 2-E-(2″-oxo-5″-acetoxy cyclopent-3″-en-1″-ylidene) ethyl benzoate, by NMR, IR and mass spectroscopic analyses. This active isolate showed very good activity against the fungal pathogen, Colletotrichum gloeosporioides.

On the identity ofHexalobus jussiaeanusBaill. (Annonaceae)

ABSTRACT The application of the name Hexalobus jussiaeanus Baill. has remained unclear since its original publication in 1868. The type, and sole basis of the species, is a specimen in the Jussieu Herbarium in Paris that lacks any information on its origins. The Jussieu specimen is found to be a collection of Uvaria narum (Dunal) Blume (Annonaceae), a species from southern India and Sri Lanka. Hexalobus jussiaeanus should therefore be considered a junior synonym of Uvaria narum.

Documentation and quantitative analysis of the local knowledge on medicinal plants in Kalrayan hills of Villupuram district, Tamil Nadu, India

Ethnopharmacological relevanceThe aim of the present study was to document the medicinal plants by the traditional medical practitioners from Kalrayan hills of Villupuram district in Tamil Nadu, India. Quantitatively analyses of the data were made to acquire some useful leads for further studies. Materials and methodsSuccessive free listing was the method adopted for the interview. In this study, 54 traditional healer medical practitioners were included and their knowledge on medicinal plants was gathered. The data were assessed with the help of two indices viz., informant consensus factor (Fic) and Informant Agreement on Remedies (IAR). ResultsThe present survey is in accordance with some of the aspects of our previous surveys. Regarding the demography of the informants, it exhibited unevenness in male–female ratio and majority of the informants were poorly educated. Practicing this system of medicine as part time job by majority of the informants might indicate the reduced social status of this medicinal system. The present study had recorded the usage of 81 species, which in turn yielded 1073 use reports. The major illness category ‘aphrodisiac, hair care and endocrinal disorders’ hold a high Fic values. Among the other illness categories, gastro-intestinal ailments, genito-urinary ailments and dermatological infection ailments have a high percentage of use reports. Eye ailments, general health, kapha ailments, psychological ailments and skeleton muscular system ailments were the other illness categories with high Fic values. Some of the claims viz., Argyrolobium roseum (aphrodisiac ailments), Rosa brunonii (eye ailments) Hibiscus surattensis (dermatological infections ailments), Bauhinia variegata (neurology Ailments), Cotinus coggygria (circulatory system/cardiovascular ailments) and Uvaria narum (gastro-intestinal ailments) which have relatively high consensus can be taken up for further biomedical studies, since no substantial studies have been conducted on them. ConclusionBased on the results of our present study, we have highlighted some claims which are at high use in the study area but having little scientific support. Studies on such claims will provide scientific base to some extent which in turn will be useful to improve the health of indigenous people.

ATTENUATING EFFECT OF UVARIA NARUM (DUNAL) WALL. LEAVES ON THIOACETAMIDE INDUCED HEPATIC INJURY

The objective of the present study was to evaluate the he patoprotective potential of U varia narum leaf extract at two different doses (200 and 400 mg / kg b.w.) against thioacetamide induced Hepatic injury . Thioacetamide at dose of 100 mg / kg induced l iver toxicity , which was ass essed by quantifying the serum h epatic biomarkers like SGPT, SGOT, ALP, total and direct bilirubin , serum biochemical parameters like albumin, total protein, cholesterol, triglycerides, glucose and urea and oxidative parameters like glutathione, catalas e, s uperoxide dismutase and lipid peroxidation in hepatic tissue. Further study was supported by histopathology studies. The results revealed that Silymarin (100 mg / kg b.w.) and Uvaria narum leaf extract at both doses prevented the elevation of serum hepatic biomarkers and also altered serum biochemical parameters dose de pendently. Whereas decrease in l ip id peroxidation and elevation in catalase, g lutathione and superoxide dismutase was observed in Silymarin and extract treated a nimals. Histopathological changes in hepatic tissue also supported the dose dep endent protective effect of Uvaria narum leaf extract . The results were comparable to reference standard Silymarin.

Volatiles of the Essential Oil of the Leaves of Uvaria narum Wall. (Annonaceae)

The essential oil of Uvaria narum Wall. (Annonaceae) leaves was analyzed by GC, GC/MS, GC/FTIR and GC-sniffing techniques. The sample was found to be rich in β-caryophyllene (9.99%), benzoic acid (9.75%), benzyl benzoate (6.23%), α-bulnesene (5.74%), β-elemene (5.6l%), α-copaene (5.39%), 3-hexenoic acid (4.46%) and germacrene-D (4.26%). In addition, further more sixty compounds, mainly sesquiterpenes (ca. 60% incl. main compounds), aromatic components (ca. 20% incl. main compounds), hexane derivatives (ca. 10% incl. main compounds) and monoterpenes (ca. 8% incl. main compounds), were also identified to be of olfactoric importance for the characteristic dry-fruity, damascone-like and osmanthus-like odor of this natural product.

A benzoic acid ester from Uvaria narum

A new benzoic acid ester, 2- E-[2″-oxo-cyclopent-3″-en-1″-ylidene]ethyl benzoate, together with tritriacontane, tetratriacontanol and β-sitosterol have been isolated from a petrol extract of the leaves of Uvaria narum. The structure of the new ester has been established on the basis of spectral data and finally confirmed by X-ray crystallography. Glut-5(6)-en-3-ol and betulapren-11-ol have also been isolated from a petrol extract of the leaves and stems of U. hookeri; this is the first report of the isolation of the latter compound from the genus Uvaria.

Antibacterial, antifungal and anthelmintic activities of root barks of Uvaria hookeri and Uvaria narum

On a pharmacological screening, substantial antibacterial, antifungal and anthelmintic activities were observed for the hexane and ethyl acetate extracts of the root barks of Uvaria narum Wall. and Uvaria hookeri King. Chromatographic fractionation of these extracts led to the isolation of the triterpenes glutinol, glutinone, taraxerol, β-sitosterol and Annonaceous acetogenins uvariamicins-I, II and III mixture, isodesacetyluvaricin, squamocin-28-one, narumicins-I and II stereoisomeric mixture, squamocin and panalicin. The acetogenins exhibited antimicrobial and anthelmintic activities in their individual screening comparable with standard drugs and hence their presence could be attributed to a great extent for the biocidal properties of U. narum and U. hookeri extracts.

The Root Bark Essential Oil ofUvaria narumWall.

ABSTRACT The constituents of the root bark essential oil of Uvaria narum Wall. (Annonaceae) from Kerala, India were analyzed by GC/MS. About 52 components were detected, out of which 22 were identified. Bornyl acetate (15.2%) and patchoulenone (8.1%), a tricyclic sesquiterpene ketone, were found to be the major individual constituents of the oil.

Complete 1H and 13C NMR spectral assignment of patchoulenone, a tricyclic sesquiterpene ketone

AbstractA tricyclic sesquiterpene ketone, patchoulenone, was isolated from the hexane extract of the root bark of Uvaria narum Wall. (Annonaceae). Its structural elucidation was based on detailed 2D NMR spectroscopy, leading to the complete assignment of the 1H and 13C NMR spectra.

Squamocin-28-one and panalicin, two acetogenins from Uvaria narum

Squamocin-28-one and panalicin, two new acetogenins containing bis-tetrahydrofuran rings were isolated and characterized in addition to a known, but stereochemically undefined, compound (squamocin) from the root bark of Uvaria narum. The relative configuration of the bis-THF part in squamocin is discussed.

Acetogenins from root bark of Uvaria narum

Three new acetogenins, isodesacetyluvaricin, narumicins I and II were isolated from hexane and ethyl acetate extracts of the root bark of Uvaria narum, in addition to the known compounds glutinone, glutinol, taraxerol, β-sitosterol and benzyl benzoate.

Uvariamicin-I, II and III: three novel acetogenins from uvaria narum

Uvariamicin-I, II and III, three novel acetogenins were characterized from the hexane extract of the root bark of Uvaria narum and their structures were elucidated on the basis of spectral evidence.

Preliminary Study of the Essential Oil Isolated fromUvaria narum

Preliminary Study of the Essential Oil Isolated from<i>Uvaria narum</i>