Fabric use for garments and other outdoor activities should have good UV absorption properties for good UV protection. Different characteristics of fabric affect their UV protection properties. This research work focus to study and model the effect of shade and construction of cotton fabric on UV protection properties using full factorial design. To study and model the effect of fabric construction 26 plain weave fabric samples of varying input parameters, e.g. ends/inch, picks/inch, warp count, weft count are selected. While to study and model the effect of shade 36 fabric samples of different L, a, b values are selected. The UV protection properties of all these fabric samples are measured by spectrophotometer. Then model of selected variables is developed with this collected data by applying response surface regression. These models show the satisfactory result and now they can be used to UV protection properties of plain bleached and dyed cotton fabric.