non-FD group was 130CC, 31CT and 11TT , whereas the distribution in FD group was 143CC, 44CT, 28TT and 8 unknown (T allele frequencies: 15.4% vs. 23.3%, p=0.0064). Overall, by logistic regression analysis after adjustment for gender, age and HP infection status, the number of rs5981521 T allele was significantly correlated to the increased risk for FD (OR, 1.45; 95%CI, 1.05-1.98; p=0.022) and TT homozygote was more closely associated with the risk for FD (OR, 3.01; 95%CI, 1.41-6.42; p=0.0043). TT homozygote had also significant risks for EPS and PDS (OR, 3.04; 95%CI, 1.25-7.42; p=0.014 and OR, 3.05; 95%CI, 1.14-8.13; p=0.026, respectively). In addition, HP negative TT homozygote had more increase risk for FD (OR, 8.37; 95%CI, 1.78-39.5; p=0.0072). Interestingly, in the subjects with SLC6A4 5'-UTR wild homozygote, the number of rs5981521 T allele was significantly correlated to the increased risk for FD (OR, 1.45; 95%CI, 1.03-2.04; p=0.033), whereas it was not in the subjects with SLC6A4 5'-UTR mutant carriers. Inversely, in the subjects with SLC6A4 3'-UTR mutant carriers, the number of rs5981521 T allele was significantly correlated to the increased risk for FD (OR, 2.07; 95%CI, 1.08-3.98; p=0.029), whereas it was not in the subjects with SLC6A4 3'-UTR wild homozygote. [Conclusions] Our results suggest that the interactions between the polymorphisms of SLC6A4 and premicroRNA 325 coding region is closely associated with dyspeptic symptom in Japanese.