Utilizing proton exchange membrane water electrolyzers (PEMWE) to produce hydrogen is a promising way to provide clean energy, reduce carbon emissions and improve the utilization rate of renewable energy. The slow kinetics of oxygen evolution reaction (OER) at the anode is considered to be the crucial obstacle to its conversion efficiency. Due to the strong acidic and oxidizing environment of OER reaction, it is essential to develop electrocatalyst with high activity and high stability to reduce the high kinetic barrier of OER and improve the reaction rate. Among them, Ru-based catalysts have outstanding catalytic activity and relatively low price, which has aroused great interest in its practical application. Many Ru-based catalysts with superior performance have been developed in recent years. In this review, we mainly focus on the development of Ru-based catalysts towards OER, with OER mechanisms discussed first, followed by discussion in the factors affecting the catalytic performance, and then introduce current research progress of Ru-based catalysts under acidic conditions. We finally conclude the prospect of the development direction of Ru-based catalysts in the future, hopefully guiding further development of Ru-based catalysts towards real world operation.