Analysis of the driving mechanisms of wetland change can help identify spatial differences in the mechanisms affecting various elements, enabling a more scientific approach to the conservation and utilization of wetlands. This study investigated the impacts of natural and anthropogenic factors on the spatiotemporal evolution of the Altay and Greater and Lesser Khingan Mountains areas using Landsat satellite image data from 1980 to 2018 and fieldwork data from 2019 to 2020. A transfer matrix, correlation analysis, and dynamic characteristics were applied to calculate and analyze the transformation types and areas of wetland resources across all consecutive periods. Finally, the dominant factors influencing the spatiotemporal evolution of the wetland were explored and revealed using the drought index (Standardized Precipitation Index, SPEI) and statistical almanacs. The results showed: (1) From 1980 to 2018, the wetlands area in the Altay Mountains exhibited a decreasing trend, whereas the wetlands area in the Greater and Lesser Khingan Mountains showed an increasing trend. The primary type of wetland transfer in the Altay Mountains was grassland, whereas in the Greater and Lesser Khingan Mountains regions, the primary types of wetland transfer were grassland and forestland. The wetlands area transferred out of the Altay Mountain region was larger than the area of wetland types transferred into during 2010–2018, whereas the wetland areas of the Greater and Lesser Khingan Mountain areas showed the opposite trend. (2) From 1980 to 2018, the wetland ecosystem types in the Altay Mountains exhibited the highest dynamic and conversion degrees of the channels. Similarly, the mountain areas of the Greater Khingan Mountains showed the highest dynamic and conversion degrees of marshes and channels among the wetland types. In addition, the mountainous areas of the Lesser Khingan Mountains showed the highest dynamic and conversion degrees for reservoirs and rivers. (3) Natural driving factor analysis revealed that the SPEI values in the Altay Mountains and the Greater and Lesser Khingan Mountains areas exhibited an increasing trend, indicating that the climate has been warm and humid over the past 30 years and that the expansion of cropland and human-made wetland areas has been significantly influenced by human activities. Therefore, the wetland areas of the Greater and Lesser Khingan Mountains in the northeast are strongly influenced by human activities, whereas the wetland in the Altay Mountains in the northwest is strongly influenced by the climate.