Potential Utilization Research Articles

Preferences of Generation Z Tourists at Selfie-Worthy Tourist Attractions in Jakarta

This research aims to understand how Generation Z engages in selfie activities at various tourist attractions in the city of Jakarta. The literature review method was employed by comparing various journals to identify key findings and applying them in the context of selfie-worthy tourist attractions in Jakarta. As a dynamic capital city, Jakarta captures the attention of Generation Z, who actively indulge in selfie activities at various locations and share them on social media. The research results indicate that selfie-worthy tourist attractions in Jakarta are influenced by Electronic Word of Mouth (E-WOM), which also contributes to the intention of returning visits. The utilization of natural potential, community participation, and the role of local government also have a significant impact on managing selfie destination spots. This study provides in-depth insights into the preferences of Generation Z tourists and integrates findings with the research on Bukit Mahoni, reinforcing the understanding of harnessing natural potential in tourism destination development. The main conclusion is that a solid understanding of Selfie Tourism trends and their application can help Jakarta build successful selfie destinations, attract Generation Z's attention, and enhance its competitiveness in the tourism industry.

Characterization of temperature-dependent subcritical water hydrolysis pattern of strong and floury rice cultivars and potential utilizations of their hydrolysates

This study investigated the effects of subcritical water (SW) temperatures on the hydrolysis pattern and characteristics of hydrolysates prepared with strong rice (SR) and floury rice (FR). The characteristics of the hydrolysates were generally dependent on the rice cultivar in the SW temperature range of 150–250 °C, while the cultivar dependence was diminished at temperatures greater than 300 °C. Based on brix and reducing sugar content, an optimal production of rice hydrolysates was obtained at a SW temperature range of 200–250 °C. However, thermal conversion of sugar into acids, 5-hydroxymethylfurfural (HMF) and furfural was manifested at 250 °C. The rice hydrolysates prepared at 250 ∼ 300 °C had the highest antioxidant activity with strong umami intensity, but they suppressed the growth of prebiotics. Therefore, the present study demonstrated that controlling the SW temperature is crucial to improve rice hydrolysis efficiency and to regulate the physiological activity of the hydrolysates.

Potential utilization of sludge extract as corrosion inhibitor for reinforcing steel in alkaline environment

The proper disposal and utilization of sludge is a critical issue around the world. This study aims to evaluate the potential of sludge extracts as inhibitors against chloride-induced corrosion of low-carbon steel. Acidic extract (ACE), alkaline extract (ALE) and water extract (WE) were obtained from pretreated sludge using nitric acid, sodium hydroxide and deionized water as extractants, respectively. Steel specimens were pre-passivated in simulated concrete pore solutions (SCPS) with and without sludge extracts. After the addition of chloride, electrochemical tests and surface analyses were performed. Results show that ACE has the highest phosphate and organic nitrogen contents, followed by ALE and WE. Electrochemical tests revealed enhanced corrosion resistance in SCPS with sludge extracts. ACE and ALE demonstrated higher corrosion inhibition efficiencies at 89.2% and 87.4%, attributed to synergistic effect of phosphate and organic ammonia nitrogen. WE exhibited reduced efficiency (69.8%) due to its low phosphate content. After long-term storage, the efficiency of WE declined significantly compared to ACE and ALE, probably due to the degradation of organic corrosion inhibition components. Mott-Schottky analysis indicated improved oxide passive film formation with all extracts, but phosphates may diminish this effect, necessitating further investigation.

Growth Performance and Environmental Quality Indices and Biomarkers in a Co-Culture of the European Sea Bass with Filter and Deposit Feeders: A Case Study of an IMTA System

This study aimed to evaluate the efficiency of an integrated multi-trophic aquaculture (IMTA) system comprising co-cultured fed fish and organic extractive species representing three distinct trophic levels as well as the impact and potential utilization of two commercially available fish feeds made up of 35% fish meal (FM) and 20% fish meal (LFM) ingredients, using a multi-indicator assessment approach. Significant alterations were observed in growth performance indicators (GPIs), water and sediment quality indices, toxicity tests and biomarkers within the IMTA system. The fish survival, weight gain (WG), and specific growth rate (SGR) were higher in the IMTA system with significantly lower feed conversion ratios (FCRs) and higher feed efficiency (FE) in comparison to the fed fish monoculture system. Yet, organic filter feeders displayed 100% survival, and increased shell growth, while deposit feeders exhibited successful survival and significant weight gain. In the comparison between FM-IMTA and LFM-IMTA, fed fish in FM-IMTA showed higher WG, SGR, and FE with lower FCR. Environmental parameters like temperature, oxygen, and nutrient concentrations fluctuated but generally improved in the IMTA system, indicating lower mesotrophic conditions. Sediment fatty acid profiles differed between systems and toxicity assessments, which suggested a lower impact in IMTA and FM-IMTA systems. The sediment microbial community displayed high similarity within IMTA systems and between FM-IMTA and LFM-IMTA. These findings underscore the potential of IMTA systems for sustainable aquaculture, emphasizing improved growth performance and reduced environmental impact, particularly when using fish meal feeds.

Peran Mahasiswa KKN 42 UIN-SU Medan dalam Pengembangan Potensi Ekonomi Masyarakat di Desa Karang Gading Kecamatan Labuhan Deli Kabupaten Deli Serdang


 Karang Gading village business owners are focused on the sustainability of their businesses. community development with social assistance methods to help with the problems being faced. The aim of Student KKN is more directed towards empowering the community with a pattern of managing existing village potential into economically valuable products, branding village potential through various assistance provided to the community regarding the utilization of local village potential which is rich in agricultural potential. This activity includes several steps, including outreach activities regarding the value of economic development through income potential in the village, product making training, practice in making processed products, KKN implementers and participants conducting evaluations and the Karang Gading Village community socializing processed products to their respective RTs as models. The community gave positive reactions to the initiatives that have been carried out. The community in particular wants events that can increase awareness of the value of the Village Economy. The community service event with the theme "The Role of KKN 42 UIN-SU Medan Students in Developing Community Economic Potential in Karang Gading Village, Labuhan Deli District, Deli Serdang Regency" has gone well and well. attended efficiently by residents of Karang Gading Village on Wednesday 20 August 2023.
 Keywords: KKN, Community Activities, Community Building

Co-gasification characteristics of Ca-rich sludge and Fe-rich sludge under CO2 atmosphere, and potential utilization of gasification residues as renewable catalyst in biomass pyrolysis

The co-gasification behaviors and performances of Ca-rich sludge (CS) and Fe-rich sludge (FS) were studied by thermogravimetric analyzer. The results showed that the comprehensive gasification index was highest at 40% CS ratio, which was 9.7 × 10−8 %2/(min2·°C3). The co-gasification resulted in more solid products generation due to that ash hindered contacts of gasifying agent and organics. By the sliding resistance furnace (SRF), in 80%CO2/20%N2, the evolution of gas compositions during the gasification process and impacts of different temperatures and blending ratios on co-gasification were evaluated. The evolution of gas compositions showed that the gas yields from CS gasification were higher than those from FS, and the interactions and ash catalytic effect during the co-gasification made the peak times earlier. The reaction temperatures and blending ratios had certain effects on the co-gasification process, affecting the mineral compositions and pores structures of sludge residues. Finally, considering the attributes of rich pores structure and Ca/Fe elements, the gasification residues can be used as ex-situ catalyst in the modification of biomass pyrolytic volatiles. Conducting the pyrolysis experiments by the SRF under N2 atmosphere, with adding gasification residues of sludge, the CO yield from biomass pyrolysis grew, but the yields of CO2, H2 and C2Hm reduced.

Digestate Application Methods and Rates with Regard to Greenhouse Gas Emissions and Crop Conditions

Digestate is commonly used as a liquid organic fertilizer, as it contains nutrients that are important for plant growth and thus help reduce usage of mineral fertilizers. Since the digestate application leads to the release of greenhouse gases (GHGs) into the atmosphere, it is necessary to find a suitable application method and fertilizer rate with minimal gas emissions while providing sufficient nutrients to crops. The aim of this study was to investigate the relationship between selected GHGs and ammonia (NH3) release into the atmosphere and different rates of digestate applied, i.e., 0, 10, 20, 30, and 40 m3 ha−1. Two digestate incorporation methods were used, i.e., a disc application unit (D) and strip-till (S). The fluxes, i.e., methane (CH4), ammonia, and carbon dioxide (CO2), were monitored using the wind tunnel method. Crop growth and potential nutrient utilization by silage maize were assessed through stand condition monitoring by the Normalized Difference Vegetation Index (NDVI) and the Normalized Difference Water Index (NDWI) using remote sensing. Under the given conditions, the digestate rates and the compared application methods had significant effects on the level of fluxes. The rate of digestate was confirmed to affect the yield of silage maize. The yield increased by more than 8% when using the disc applicator. Based on our results, it is advisable to apply digestate by strip-till technology at rates of approximately 20 m3 ha−1.

Concentration of novel urinary tract infection biomarkers in neonates

Urinary tract infections (UTIs) are a common comorbidity in hospitalized neonates. The current UTI diagnostics have several limitations including invasive collection of urinary samples to ensure sterility, risk of contamination and lack of consensus definitions of UTI based on urine culture. Antimicrobial peptides (AMPs) have been recently utilized as novel biomarkers that can efficiently and accurately diagnose pediatric UTI. However, the concentration of AMPs in neonatal urine is not well-defined. Urine from neonates admitted to a single level IV neonatal intensive care unit was obtained to determine baseline concentration of two AMPs, Ribonuclease 7 (RNase 7) and Beta Defensin-1 (BD-1) and to define the relationship between AMP concentration and gestational age (GA). AMP levels were normalized to urine creatinine. RNase 7 and BD-1 were expressed in neonatal urine (n = 66) regardless of GA and as early as 22 weeks gestation. Urinary concentrations of both AMPs decreased as GA and birthweight increased. The overall median urinary RNase 7/UCr and BD-1/UCr values were 271 ng/mg, and 116 ng/mg, respectively. Median urinary concentrations of RNase 7/UCr for infants born at < 27, 27–32, 33–35 and ≥ 36 weeks were 569, 308, 254, and 124 ng/mg respectively. Similarly, the concentrations of BD-1/UCr at these GA were 166, 115, 108, and 14 ng/mg, respectively. Baseline neonatal urinary concentration of two AMPs (RNase 7 and BD-1) and the variation by GA were identified. This is an essential first step toward the potential utilization of AMPs in improving neonatal UTI diagnostics.

Synthesis of diverse aryl‐substituted amino propanes

AbstractAmines bearing diverse aryl substituents for potential utilities as energy and new materials have been synthesized from aziridine‐2‐carboxaldehyde and diverse aryl‐containing substrates. At first two aryl groups were to yield (aziridine‐2‐yl)‐1,1‐diaryl‐methane which was converted to 5‐diarylmethyl oxazolidin‐2‐one as a synthetic intermediate. They were further reacted with another aryl group in the presence of methanesulfonic acid to yield 2,3,3‐triarylpropylamine with the possible carbenium ion intermediate. In addition, this reaction with a second additional phenolic aryl group gave rise to the diversely substituted 3‐(4‐methoxyphenyl)‐(2,3‐dihydrobenzofuran‐2‐yl)methanamine derived from the intramolecular aziridine ring‐opening reaction by hydroxy group at phenol.

Experimental Study on the Potential Utilization of Olive Oil Production Wastes and By-Products as Building Materials

The construction industry is one of the sectors with the greatest environmental impact resulting from the high consumption of resources and the huge amount of waste generated. In addition, different wastes and by-products originate from various sectors of activity, namely the ones related to the agricultural sector, requiring the urgent actions of recycling and reuse. In this context, this investigation focused on the valorization of wastes and by-products resulting from the olive oil production as building material components. Wet bagasse was added to cementitious mixtures at percentages of 5% and 20% to produce solid blocks. Lime mortars, incorporating 2% and 8% of ash, were developed, and particleboards composed of 83% olive stone were also produced. The results showed that blocks with 5% waste complied with the standard requirements for flexural strength. The incorporation of 2% ash increased the mechanical properties of lime mortars when compared to a reference mortar with no ash. The developed particleboards revealed the possibility for being part of a multilayer solution or as a covering material, presenting a thermal conductivity of 0.08 W/mK. Thus, wastes generated during olive oil production presented potential for valorization as building material components for non-structural purposes.

Exploring polyhydroxyalkanoates biosynthesis using hydrocarbons as carbon source: a comprehensive review.

Environmental pollution caused by petrochemical hydrocarbons (HC) and plastic waste is a pressing global challenge. However, there is a promising solution in the form of bacteria that possess the ability to degrade HC, making them valuable tools for remediating contaminated environments and effluents. Moreover, some of these bacteria offer far-reaching potential beyond bioremediation, as they can also be utilized to produce polyhydroxyalkanoates (PHAs), a common type of bioplastics. The accumulation of PHAs in bacterial cells is facilitated in environments with high C/N or C/P ratio, which are often found in HC-contaminated environments and effluents. Consequently, some HC-degrading bacteria can be employed to simultaneously produce PHAs and conduct biodegradation processes. Although bacterial bioplastic production has been thoroughly studied, production costs are still too high compared to petroleum-derived plastics. This article aims to provide a comprehensive review of recent scientific advancements concerning the capacity of HC-degrading bacteria to produce PHAs. It will delve into the microbial strains involved and the types of bioplastics generated, as well as the primary pathways for HC biodegradation and PHAs production. In essence, we propose the potential utilization of HC-degrading bacteria as a versatile tool to tackle two major environmental challenges: HC pollution and the accumulation of plastic waste. Through a comprehensive analysis of strengths and weaknesses in this aspect, this review aims to pave the way for future research in this area, with the goal of facilitating and promoting investigation in a field where obtaining PHAs from HC remains a costly and challenging process.

One-Step Synthesis and Operando Electrochemical Impedance Spectroscopic Characterization of Heterostructured MoP-Mo2N Electrocatalysts for Stable Hydrogen Evolution Reaction.

This study presents a novel synthesis of self-standing MoP and Mo2N heterostructured electrocatalysts with enhanced stability and catalytic performance. Facilitated by the controlled phase and interfacial microstructure, the seamless structures of these catalysts minimize internal resistivity and prevent local corrosion, contributing to increased stability. The chemical synthesis proceeds with an etching step to activate the surface, followed by phosphor-nitriding in a chemical vapor deposition chamber to produce MoP-Mo2N@Mo heterostructured electrocatalysts. X-ray diffraction analyses confirmed the presence of MoP, Mo2N, and Mo phases in the electrocatalyst. Morphology studies using scanning electron microscopy characterize the hierarchical growth of structures, indicating successful formation of the heterostructure. X-ray photoelectron spectroscopy (XPS) analyses of the as-synthesized and postcatalytic activity samples reveal the chemical shift in terms of the binding energy (BE) of the Mo 3d XPS peak, especially after catalytic activity. The XPS BE shifts are attributed to changes in the oxidation state, electron transfer, and surface reconstruction during catalysis. Electrochemical evaluation of the catalysts indicates the superior performance of the MoP-Mo2N@Mo heterostructured catalyst in hydrogen evolution reactions (HER), with lower overpotentials and enhanced Tafel slopes. The stability tests reveal changes in double layer capacitance over time, suggesting surface reconstruction and an increased active surface area during catalysis. Operando electrochemical impedance spectroscopy (EIS) further elucidates the dynamic changes in resistance and charge transfer during HER. Overall, a comprehensive understanding of the synthesis, characterization, and electrochemical behavior of the developed MoP-Mo2N@Mo heterostructured electrocatalyst, as presented in this work, highlights its potential utilization in sustainable energy applications.

Molecular modelling of fullerene C60 functionalized by nitric oxide for use in biological environment

The unique potential of fullerene C60 for various biological applications has ignited significant interest. However, its inherent non-polarity poses a critical challenge for its effective integration within biological systems. This study delves into the intricate physicochemical characteristics of the innovative [C60 + NO] complex using density functional theory and time-dependent density functional theory. The computational analyses encompass molecular charge, surface electrostatic potential, and dipole moment evaluations. Impressively, the dipole moment of the [C60 + NO] complex significantly increases to 12.92 D. Meticulous surface analysis reveals a subtle interplay between molecular structures, indicating weak interactions. The analysis of the absorption spectrum unveils a noteworthy red-shift of 200 nm subsequent to complex formation. To elucidate the electron transfer mechanisms, we explore photo-induced electron transfer through CAM-B3LYP. This exploration elucidates intricate pathways governing electron transfer, with complementary insights gleaned from Marcus theory's outputs, especially the Gibbs free energy of electron transfer. Changes in the physicochemical properties of approaching C60 and NO molecules reveal interesting results compared to separate molecules. These findings resonate profoundly in the context of potential biological and pharmaceutical utilization. With implications for the biomedical area, the outcomes linked to the [C60 + NO] complex kindle optimism for pioneering biomedical applications.

A STUDY OF THE INFORMATION AND COMMUNICATIONS TECHNOLOGY MATURITY OF THE NIGERIAN NAVY FORCE

The rate of ICT growth in the Nigerian Navy Forces is still appallingly low. Given the aforementioned factor, assessing the Nigerian Navy Force's ICT maturity level is critical as this could offer helpful insight into how to successfully integrate ICT into the Nigerian Navy Force. This research work adopted the Small-size and Medium-size Enterprises ICT Maturity model in examining and measuring the optimal utilization of technology in Nigeria Navy Force. A questionnaire designed after ICT Maturity Model of SMEs containing forty-five research questions guided this project work. The questionnaires were afterward sorted and coded according to the responses from the 30 Senior Commissioned Officers, 30 Junior Commissioned Officer and 30 Non-Commissioned Officers that participated in this research survey using the indicator stage value in the coding process. The required ICT Maturity Indexes were extracted from the respective commands and were subsequently calculated using the Microsoft Excel Spreadsheet. Nigerian Navy Commands and unit were carefully selected and their ICT calculated to be significantly substantial with ICT maturity level at 0.58. This result analysis shows that ICT’s innovations and capacities are yet to be effectually and efficiently exploited within the Nigerian Navy Force. The research offers helpful insight into how to successfully integrate and measure the utilization of ICT potentials in the Nigerian Navy Force for its training and operations. The knowledge acquired would also be very beneficial for planning, budgeting, and setting funding priorities that will be specifically focused on the requirements area.

Adjusting Electronic Properties of Janus SHfAZ2 (A═Si,Ge; Z═N, P, As) via Strain Engineering and an Electric Field

AbstractIn this work, novel monolayers of 2D Janus SHfAZ2 (A═Si, Ge; Z═N, P, As) materials are introduced. These Janus structures are primarily investigated for their ability to exhibit adjustable electronic properties when subjected to biaxial strain and an applied electric field. At equilibrium, the four structures in the Janus SHfAZ2 monolayers all display indirect bandgap semiconductor properties, with the exception of the SHfGeN2 monolayer, which exhibits direct bandgap semiconductor properties. Under the influence of biaxial strain, the study observes that the electronic properties of all SHfAZ2 monolayers can be adjusted, transitioning from semiconductor to metallic properties when subjected to compressive strain. However, the SHfSiP2, SHfGeP2, and SHfGeAs2 monolayers show limited sensitivity to an applied electric field, with their electronic properties being modifiable solely under the influence of applied biaxial strain. In contrast, both the SHfSiAs2 and SHfGeN2 monolayers demonstrate the ability to modulate their electronic properties from semiconductors to metals when subjected to both biaxial strain and an applied electric field. Finally, the carrier mobility of these five structures is calculated. The outcomes of the research provide a solid theoretical foundation for the potential utilization of 2D Janus SHfAZ2 monolayers in electronic devices.

Subsurface Utility Identification at ITERA Campus Using Multi-frequency Ground Penetrating Radar

Infrastructure development at the Sumatra Institute of Technology is growing rapidly, hence, it requires new utilities installation network such as cables and pipes to supply electricity and clean water. Installing new utility line, it is necessary to secure and know the existence and depth of the previously embedded utility network to avoid damage that could hamper the construction process or cause large losses. Accessing the sub-surface information, geophysical method, such as Ground Penetrating Radar (GPR) can be utilized for identifying buried utility networks, ensuring the safe installation of new utilities and preventing damage to existing embedded utilities. In this study, a GPR device with a frequency range 40 MHz-3.4 GHz comprising 5 tracks was employed. The acquired data underwent processing using GPR Insights software, generating a radargram cross-section that provides information about the subsurface.The results from the radargram reveal a hyperbolic reflection anomaly, signifying the presence of a utility network beneath the surface, suspected to be pipe and cable utilities. The utility network is detected at varying depths of 0.5 m, 0.8 m, 1 m, and 1.2 m at different distances. Furthermore, several anomalies in the form of hyperbolas are observed, suggesting potential utilities due to their continuity with other paths.

The Application of Cryogenic Carbon Capture Technology on the Dual-Fuel Ship through the Utilisation of LNG Cold Potential

The International Maritime Organization (IMO) has set targets to reduce carbon emissions from shipping by 40% by 2030 (IMO2030) and 70% by 2040 (IMO2050). Within the framework of decarbonising the shipping industry, liquefied natural gas (LNG) fuel and carbon capture technologies are envisioned as a transitional option toward a pathway for clean energy fuels. The aim of the complex experimental and computational studies performed was to evaluate the CO2 capture potential through the utilisation of LNG cold potential on the FSR-type vessel within a dual-fuel propulsion system. Based on the experimental studies focused on actual FSRU-type vessel performance, the energy efficiency indicators of the heat exchanging machinery were determined to fluctuate at a 0.78–0.99 ratio. The data obtained were used to perform an algorithm-based systematic comparison of energy balances between LNG regasification and fuel combustion cycles on an FSRU-type vessel. In the due course of research, it was determined that LNG fuel combustion requires 18,254 kJ/kg energy to separate and capture CO2 in the liquid phase to form exhaust gas; meanwhile, low sulfur marine diesel oil (LSMDO) requires 13,889 kJ/kg of energy. According to the performed calculations, the regasification of 1 kg LNG requires 1018 kJ/kg energy, achieving a cryogenic carbon capture ratio of 5–6% using LNG as a fuel and 7–8% using LSMDO as a fuel. The field of carbon capture in the maritime industry is currently in its pioneering stage, and the results achieved through research establish an informative foundation that is crucial for the constructive development and practical implementation of cryogenic carbon capture technology on dual-fuel ships.

PteridophytaE-Encyclopedia of Kelud Mountain to Study of the Diversity of Fern Species in the Environment on the RICOSRE Model to Improve Student’s Information Literacy

The low level of information literacy and the lack of utilization of local potential is one of the reasons to develop the learning innovations. One of innovation is utilize local potential as a learning resource in the form of an e-encyclopedia and integrate it with the RICOSRE learning model. This research aims to determine the feasibility, practicality, and effectiveness from the pteridophyta e-encyclopedia of Kelud Mount for studying the diversity of fern species on RICOSRE model to increase information literacy. This research uses the development research with the ADDIE design and implemented in class X of students at SMA Negeri 1 Talun. The instruments research were questionnaires and information literacy rubrics. The data result was analyzed using the percentage equation, while information literacy data was analyzed with N-Gain equation and Independent Sample T-Test. The research results show that the pteridophyta e-encyclopedia are feasible by lecturer and stated to be practical by teachers and students. The conclusion is the information literacy of students who use e-encyclopaedia’s in RICOSRE learning is proven to be higher than students who do not use it.

The Assessment of Sewage Sludge Utilization in Closed-Loop Economy from an Environmental Perspective

Sewage sludge, a by-product of wastewater treatment, is garnering increasing attention in the pursuit of closed-loop economy practices due to its highly beneficial fertilizing properties. However, like any technique, using sewage sludge as fertilizer has potential and limitations. Heavy metals within sewage sludge are a primary limitation curtailing its application as a fertilizer. This study collected sewage sludge samples from four wastewater treatment plants and soil from potential application sites. The mobility of heavy metals was then examined using a sequential BCR analysis. Furthermore, a comprehensive environmental risk assessment associated with the agricultural use of sewage sludge was conducted, using various risk indicators such as Igeo and Nemerov, to compare the cumulative metal concentrations in the sewage sludge and soil. Additionally, risk assessment codes, ecological risk indices of metal mobility, and environmental risk indices were calculated, specifically focusing on the mobility of metals in the soil environment. This research demonstrates that sewage sludge failing to meet conventional criteria for agricultural use based on total metal content does not necessarily pose a high-risk application. Understanding the mobility forms of metals in sewage sludge is crucial, influencing the analysis of their potential utilization. Importantly, sewage sludge from wastewater treatment plants utilizing biological bed technology tends to exhibit a higher tendency of heavy metals to exist in mobile forms, migrating within the soil environment.

Chemical exploration of different extracts from Phytolacca americana leaves and their potential utilization for global health problems: ın silico and network pharmacology validation

Phytolacca americana L. is of great interest as a traditional additive in various folk remedies in several countries, including Turkey. We aimed to determine the chemical profile (assisted by high-Performance liquid chromatography-electrospray ionization-tandem mass apectrometry (HPLC-ESI-MS/MS) experiments of three extracts obtained by different polarity solvents viz. ethyl acetate (to extract semipolar compounds), methanol and water (to extract highly polar metabolites) from P. americana leaves. Their anti-diabetic effects were investigated in vitro by assessing their inhibition toα-amylase and α-glucosidase. Assessment of the neuroprotective potential of the three extracts was carried out against acetyl-(AChE) and butyryl-(BChE) cholinesterase enzymes. HPLC-ESI-MS/MS experiments showed a total of 17 chromatographic peaks primarily classified to six flavonoids, two saponins, and six fatty acids. Antioxidant assays revealed remarkable activity for the ethyl acetate and methanol extracts. The BChE inhibition was considerably more significant (4.08 mg galantamine equivalent (GALAE)/g) for the ethyl acetate extract, whereas the methanol extract had good inhibitory efficacy for AChE (2.05 mg GALAE/g). Through network pharmacology, the compounds’ mechanism of action of targeted key gene in their associated diseases were identified. The hubb gene signal transducer and activator of transcription 3 (STAT3) and tumour necrosis factor (TNFα) where the P. americana compound’s site of action in inflammation bowel disease. The results offer possibilities for the prospective application of P. americana in metabolic regulation, blood glucose control, and as a source of bioactive compounds with cholinesterase enzyme inhibitory characteristics which could be of relevance in the cosmetic or pharmaceutical industry for combating melanogenesis. Communicated by Ramaswamy H. Sarma