Background: Urinary tract infections are among the most common infections of childhood. The diagnosis of UTI is often missed in infants and young children since symptoms are minimally expressed and non-specific. Younger age, inadequate antibacterial therapy and recurrent infections and delayed diagnosis often lead to further complications. Methods: The symptoms of UTI can be correlated to Mutrakrcchra, which is explained in Samhitas. Acharya Kashyapa had explained in detail Mutrakrcchra in children in Mutrakrcchra Chiktsadyaya. The Nirgundyadi Kashaya Yoga in Sahasrayoga is explained in Kashaya Prakarana and indicated in Krimi Chikitsa. Results: The Yoga is found effectively prescribed in children with UTI. This article analyses the probable mode of action in terms of its Samprapti Vighatana in children. Conclusion: The analysis of the drugs and their therapeutic efficacy in Ayurvedic point of view, which will be elaborated, can aid the validation of practices in the paediatric age group.