Uterine Growth Retardation Research Articles

COMPARISON OF PLGF LEVELS, AMONG SMALL FOR GESTATIONAL AGE AND APPROPRIATE FOR GESTATIONAL AGE MOTHERS

Objective. Early detection of small for gestational age fetuses can prevent infant morbidity and mortality. The objective of this study was to compare the levels of Placental Growth Factor among small for gestational age with appropriate for gestational age mothers and to identify the predictive value of PlGF in detecting pregnancies with Intra uterine growth retardation in local population. Design. Quasi experimental (comparative cross-sectional) study. Place & duration of study. Gynecological department of Ayub Medical complex, Abbottabad from August 2021 to January 2022. Methodology. The studied population included total 68 mothers in last trimester with 34 in each group, i.e. appropriate for gestational age and small for gestational age. Fetal size was estimated either by clinical examination (symphysis fundal height) or estimated fetal weight by ultrasound examination. Sociodemographic along with reproductive history were recorded and blood samples analyzed for PlGF difference in both groups. Results. The median age of mothers was 32.5 years. The PlGF in small for gestational age was observed in the below normal concentration (mean value = 126.7 pg/mL) while it was observed in normal ranges in appropriate for gestational age mothers (mean value = 24.2 pg/ml) with P-value (<0.001). Conclusion. Mothers with small for gestational age were having significantly lower placental growth factor levels compared to mothers with appropriate for gestational age.

A SYSTEMATIC REVIEW OF THE CRUCIAL ROLE OF RASA DHATU IN PRODUCING HEALTHY PROGENY.

Each year in India, there are approximately 28 million pregnancies, in which 26 million live births, a million neonatal deaths & congenital deformities is occurring due to malnutrition of mother and fetus. The classics of Ayurveda detail the crucial role of Rasa dhatu in the production of healthy progeny. During gametogenesis, Rasa dhatu is the foremost requirement for normal, healthy sperm and oocytes (Shukra & Artava). Malformed paternal Rasa dhatu leads to malnourished and malformed gametocytes through mitochondrial dysfunction, epigenetics and defects in meiosis cause Bija dosha, which in turn lead to Garbhshrava (miscarriage), deformed Garbha formation or congenital deformities like Suchi Mukh uterus in female fetus and sterile progeny. After fertilization, the ceased Artava (accumulated nutritional substance in the fluid of decidual cells) acts as a storage nutrition for the developing embryo in the embryonic phase. During organogenesis the Artava which is the Upadhatu of Rasa dhatu forms the maternal part of placenta. After formation of placenta & umbilical cord the Maternal Rasa dhatu provides directly nutrition to growing fetus. The malformed Rasa dhatu or the blocked Rasavaha channels of mother may cause different levels of intra uterine growth retardation such as Nagdhadara, Upavistaka, Lina garbha, Garbhashaya or Mritgarbha (IUD).

THE EFFECT OF CONSUMING FE TABLETS AND VITAMIN C COMBINATION TABLETS ON HB LEVELS IN PREGNANT WOMEN AT SHAQI CLINIC SEYEGAN IN 2023

Pregnancy with anemia increases the risk of morbidity and mortality because it causes postpartum hemorrhage. In addition, mothers with anemia can experience difficulty breathing, fainting, fatigue, increased heart rate, difficulty sleeping, perinatal infections, and pre eclampsia. It also has an impact on pregnancy outcomes, namely babies can experience Intra Uterine Growth Retardation (IUGR) and LBW. The study aims to determine the effect of consuming Fe tablets and Vitamin C combination tablets on Hb levels in pregnant women. This study employed Quasy experimental research with One Group pre-test and post-test design obtained directly from respondents through questionnaires that have been prepared by researchers and the data obtained by researchers are processed using the Wilcoxon test. The results of statistical tests using the Wilcoxon test showed a P value of 0.001 (<0.05), meaning that there was an effect before and after giving FE tablets combined with vitamin C on hemoglobin levels in pregnant women. The results showed that from a total of 15 respondents who experienced anemia before treatment decreased to 2 respondents who experienced anemia after treatment. The patients are suggested to follow the instructions given by health workers when doing ANC anywhere to be obedient in taking Fe tablets combined with vitamin C as prevention and treatment of anemia during pregnancy.

A Case of Neonatal Diabetes and Multiple Congenital Anomalies: Variant of Mitchell-riley/Martinez-frias Syndrome

Neonatal diabetes along with congenital anomalies like duodenal atresia, tracheoesophageal fistula, intra uterine growth retardation, extrahepatic biliary obstruction and hypoplasia of pancreas is a very rare occurrence with evidence linking it to RFX6 gene mutation. The presence in newborn babies necessitates a detailed genetic evaluation and multidisciplinary management. Here, we present a preterm baby with persistent neonatal hyperglycemia and gastrointestinal anomalies similar to cases associated with Mitchel-riley/Martinez-frias syndrome.

Gender-Based Violence and its Effect on Mother, Fetus and Newborn Baby: A Systematic Review

Abstract: Gender-based violence (GBV) is a major public health concern resulting in physical, psychological, sexual, and social issues. GBV during pregnancy may results in complicated and grave consequences for mother and unborn child. The prevalence of GBV was reportedly higher in developing countries, indicating higher maternal and child mortalities. Effect of GBV on pregnancy has been reported to enhance the chances of prolonged labor, obstructed labor and in severe injuries higher incidents of miscarriages and abortions are also been reported. Moreover, fetal respiratory distress, diarrhea, small for gestaional age and Intra Uterine Growth Retardation (IUGR) have also been reported. This review aims to present a systematic view of genderbased violence and its association with adverse pregnancy outcomes and to contribute by filling the existing information gap. Review assessed the effect of GBV during pregnancy on fetal health, reporting infant diarrhea more frequently, along with fever, vomiting, and respiratory distress. The significant association between adverse maternal and fetal outcomes and gender-based violence has been evaluated extensively.

Overview of Knowledge of Pregnant Women About the Dangers of HIV/AIDS at the Pratama Nusantara Clinic Mandau District Bengkalis Regency in 2019

HIV/AIDS is a relatively well-known disease with many health problems, especially when it occurs in pregnant women. Dangers that can occur such as immune system disorders and pregnant women are susceptible to infection, pregnancy will fight the progress of HIV infection, conversely the effects of HIV in pregnancy are intra uterine growth retardation and low birth weight, as well as increased preterm birth and the baby can also be infected in the womb. HIV continues to be a major problem in the world, so far it has claimed more than 35 million lives. At the end of 2017, there were around 36.5 million people living with HIV and 1.8 million people newly infected with HIV worldwide. About 59% of adults and 52% of children with HIV are on lifelong antiretroviral therapy (ART). The high coverage of ART in the world for pregnant and lactating women is 80%. This study aims to describe the knowledge of pregnant women about the dangers of HIV/AIDS at the Pratama Nusantara Clinic, Mandau District, Bengkalis Regency in 2019. The research design used is descriptive quantitative. The research was conducted from June 1 to June 20 2019. The population in this study consisted of 38 pregnant women with a sample of 35 people using Simple Random Sampling. Data were obtained from primary and secondary data for further analysis of the data univariately. The results showed that the majority of pregnant women lacked knowledge about the dangers of HIV/AIDS as many as 18 people (51.43%), at the age of 20-35 years as many as 10 people (28.57%), high school education level as many as 8 people (22.86 %) %), and 7 people (20%) got information about the dangers of HIV/AIDS through electronic media. It is expected that pregnant women will further increase their knowledge by adding information from various media and more often participate in counseling programs conducted by health workers/facilities and participate in carrying out HIV/AIDS testing during pregnancy.

Interventions required and outcome in pregnancy induced hypertension patients in Intensive Care Unit: An observational study

Hypertensive disorders of pregnancy, particularly preeclampsia, eclampsia remain one of the leading causes of maternal morbidity and mortality worldwide. We studied the association between the risk factors, interventions required, diagnosis and outcome in these patients admitted to the Intensive Care Unit (ICU).: We conducted a prospective, observational study after the Institutional Scientific and Ethics committee approval. The Institutional record was taken to identify 70 women with Pregnancy Induced Hypertension (PIH) admitted to ICU after meeting the inclusion and exclusion criteria. Socio-demographic details, indication and timing of ICU admission were noted. On ICU admission; baseline vitals, detailed history, duration of complications, therapeutic interventions, laboratory parameters and imaging were compiled. Maternal outcome was assessed in terms of interventions needed, complications encountered and mortality or discharge and follow up was done up to 6 weeks postpartum. Fetal outcome was assessed in terms of live births or Intrauterine fetal death (IUFD), Apgar score, term/preterm and followed up to 7 postnatal days.: It was observed that out of 70 women enrolled in our study, 48 women were diagnosed with preeclampsia, 54 belonged to the age group of 21-30 years, 61 were unregistered for antenatal checkup, 46 had term gestation, 52 were nulliparous and 64 underwent Lower segment caesarean section (LSCS). 60 of them had postpartum ICU admission, all of them had significant rise in blood pressure. Most common interventions were transfusion of blood products (n=30) and mechanical ventilation (n=6). HELLP syndrome was the most common complication (n=7). Maternal mortality was seen in 6 women. 35 neonates had low birth weight, 6 had intra uterine growth retardation (IUGR), 19 were preterm and Apgar score was significant at 5 minutes.: From our observations, it can be concluded that majority of the women were diagnosed with preeclampsia, were relatively of younger age group, nulliparous with no antenatal checkup, underwent LSCS and were admitted postpartum to ICU. Transfusion of blood products was the most common intervention & HELLP syndrome was most common complication. Maternal mortality was higher in women with preeclampsia although overall mortality was low. The incidence of low birth weight, IUGR and preterm neonates was more in eclamptic women. Neonatal mortality was more in preeclamptic women.

MANAGING ANTI-EPILEPTIC DRUGS DURING PREGNANCY ; EVOLVING CONCEPT

Epilepsy is one of the few neurological disorders that require a constant treatment during pregnancy.Besides epilepsy Anti-epileptic drugs (AEDs) are also commonly used for psychiatric disorders,pain disorders,and migraines. No Anti-epileptic drugs is safe during pregnancy . Anti-epiletic drugs exposure during pregnancy causing intra- uterine growth retardation,cognitive dysfunction,low IQ,microcephaly,major conjenital anomalies and infant mortality. Use of anti-epileptic drugs (AEDs) in pregnant women with epilepsy requires monitorning and maintaining a balance between limiting seizures and decreasing fetal exposure to the potential teratogenic effects. In this review we analysed the data on the pharmacokinetics of various AEDs in pregnancy, neurological teratogenic effects and providing a basis for management of safety of AEDs during pregnancy

КЛИНИКО-ЛАБОРАТОРНЫЕ ПОКАЗАТЕЛИ БЕРЕМЕННЫХ КОРОВ, ПРЕДРАСПОЛОЖЕННЫХ К РАЗВИТИЮ ГЕСТОЗА

The article presents materials on studying clinical and laboratory indicators of pregnant cows at 60 days of gestation, prone to the development of gestosis. In cows with the uterine fetal growth retardation syndrome at 2 months of pregnancy, subsequently complicated by gestosis, the established morphobiochemical changes indicate failures in the protein metabolism, functioning of the liver, kidneys, and the circulatory system. The changes also show an intensive accumulation of lipid peroxidation products, with a decrease in the activity of the enzymatic and non-enzymatic link of the AOD. The development of the fetal intrauterine growth retardation syndrome occurs against the background of a trophism disorders in the developing embryo. This at early stages of pregnancy is clinically manifested by a decrease in the size of the uterine horn cavity by 22.2-34.2%, the length of the fetus – by 41.5-48.9%, the body diameter – by 19.9-28.9%, the size of the corpus luteum of the ovary – by 15.7-24.1%.

Reproductive Outcome in Women with different Types of Congenital Uterine Anomalies

Introduction: Mullerian ducts are the primordial analogue of female genital tract. They differentiate to form the fallopian tubes, uterine body, cervix and upper part of the vagina. A wide variety of malformation occur when this system is disrupted. The range from uterine agenesis, duplication of uterus to minor cavity abnormalities. All these congenital anomalies have been implicated as a potential cause for impaired reproductive outcome. Our aim was to evaluate the association between different types of congenital anomaly and various reproductive outcome. Material & Methods: This cross sectional descriptive study was conducted at the Department of gynae and obstetrics in Dhaka Medical College and Hospital (DMCH), Ad-din Women’s Medical College and Hospital and Gonoshasthaya Samaj Vittik Medical College and Hospital during the period of March 2012 to September 2022.The study subjects were women with uterine anomalies who were diagnosed during evaluation of causes for bad obstetric history, during infertility work up or incidental findings during antenatal investigations or during Carsarian section . Reproductive outcomes were observed in the form of infertility, miscarriage, preterm delivery, ectopic pregnancy, intra uterine growth retardation (IUGR) and post-partum haemorrhage (PPH). These were recorded in a standard research questionnaire. Data were analyzed regarding types of uterine anomalies and their reproductive performance. Results: During the study period total 84 patients were recruited with uterine anomalies. Regarding distributions of uterine anomalies in study subjects the most common uterine anomaly was bicornuate uterus (n-32,38%), followed by arcuate uterus (n-18,21%), septate uterus (n-16,19%), unicornuate uterus (n-12,14%), and uterine didelphys (n-6,7. 1%).Women with bicornuate uterus was associated with miscarriage (37.25%), term delivery (31.25%) and preterm delivery (25%). Therefore, bicornuate uterus was found more evident with miscarriage. Only two cases of ectopic pregnancy were observed in the study which was found with bicornuate uterus. And in arcuate uterus percentage of preterm delivery was 44.4%, term delivery 33.3%, miscarriage only 22.2%. Therefore, arcuate uterus was more associated with preterm delivery. In septate uterus miscarriage was maximum (37.5%) followed byl term and pre term delivery, 12.5% each We found 12 cases of unicornuateuterus, where pregnancy continued to term in 6(50%) cases,2 aborted and 4(33.3)were delivered before term. Infertility was more associated with canalization defect, 6 cases with septate and 2 with didelphys uterus. Among live births (preterm and term deliveries,) malpresentation (breech, transverse) was more common in bicornuate uterus (44%).PPh was found in 2 cases of didelphys and two of bicornuate uterus. One case of septate and one from bicornuate uterus were associated with IUGR. Conclusion: The study makes clear that congenital uterine anomaly is associated with poor reproductive outcome. The exact effect is dependent on the type of anomaly.

Maternal Anemia and BMI as Determinants of Pregnancy Outcomes: A Hospital-Based Study.

Malnutrition is a serious underlying cause of child and maternal deaths around the world. The objective of this study evaluates maternal anemia and body mass index as determinants of pregnancy outcomes. Undernourishment during pregnancy can occurs Intra Uterine Growth Retardation. Contributing to about 80,0000 new-borns, 40,0000 infant deaths and 20% under 2 years children have stunted, 20% of maternal deaths during labor and early postpartum. This study Hospital-based cross-sectional study. The study comprised laboring women admitted for delivery in selected tertiary care hospital in South India from 10th November 2021 to 20th January 2022. Structured interview schedule for demographic information, patient's case sheet for information about the 'Body Mass Index as a determinants of pregnancy outcomes' and anthropometric measurement for body mass index (weight and height). All registered deliveries in the study period have been included, comprising of 101 sample size Bivariate logistic regressions were used to determine the factors associated with outcome variables. A significant level of 5% was used to decide the significance of statistical tests. Body Mass Index in the 1st antenatal visit of the women who came for delivery in tertiary care hospital, underweight 36.6%, normal body mass index 52.5%, and overweight 10.9%. During 1st antenatal visit 58.4% had anemia, while 53.5% had mild anemia during the last antenatal visit. Respectively 39.6% of antenatal women had normal Hb% during 1st antenatal care visit, whereas 46.5% had normal Hb%, during their last antenatal visit. The mode of delivery; spontaneous vaginal delivery 45.5%, vacuum delivery 3.0%, emergency caesarean section delivery 50.5%. Preterm delivery was statistically significant among whose first antenatal care visit was after 11th weeks of gestation. Whereas, emergency caesarean section delivery was statistically significant among underweight. Increasing maternal weight body mass index was associated with maternal and neonatal health outcomes. Which was risk of pregnancy induced hypertension, preeclampsia, eclampsia, gestational diabetes mellitus and caesarean section delivery. Every 2nd women was anemic, every 3rd pregnant women was underweight (BMI >18.5), every 2nd baby was born with caesarean section delivery. Preterm delivery was statically significant of weeks of gestation during first antenatal care visit with more than 11th weeks of gestation. Whereas, emergency cesarean section was significant with low body mass index.

PMON193 Reactive oxygen species in the development of gonadal failure in late-onset transaldolase deficiency

Abstract Background Deficiency in Transaldolase, an essential enzyme in regulating NADPH and ribose 5-phosphate production, has been reported in only 39 patients to date. Most patients present already prenatally/neonatally with intra uterine growth retardation, hepato(spleno)megaly and consequent liver failure, anemia, thrombocytopenia, dysmorphic facial features, cardiac and skin abnormalities and hypergonadotropic hypogonadism in cases of late-onset presentation. The mechanism underlying gonadal dysfunction is not fully understood. Clinical case, methods and results A 15y old male from an Indian-Jewish background, with atrial-septal-defect, renal tubulopathy, mild facial dysmorphism and transient liver enzymes abnormalities presented with absence of pubertal development. His gonadotropins levels were elevated (LH – 22 IU/L, FSH 103 IU/L) while testosterone was low. Whole exome sequencing revealed homozygous variant in a novel T167M missense mutation in TALDO1 (transaldolase) gene whereas both parents were heterozygote carriers. Proteine structure analysis indicate that Threonine 167 is part of transaldolase catalytic site and critical for its function. As transaldolase activity is required for nucleic acids production, NADPH synthesis and reduction of cellular Reactive Oxygen Species (ROS) we measured the ROS accumulation using 2′,7′-dichlorodihydrofluorescein diacetate, in fibroblasts derived from the patient and normal controls. The affected patient's fibroblasts showed a significantly increased accumulation of ROS (207%, P=0.007), compared to controls indicating an increased susceptibility to oxidative stress. Conclusion The novel T167M missense mutation in the transaldolase (TALDO1) gene causes a unique clinical presentation including a relative mild liver involvement and hypergonadotrophic hypogonadism. The compromised TALDO1 activity in preventing cellular ROS accumulation in actual patient's fibroblasts is shown here for the first time and may indicate the therapeutic use of antioxidants in all patients with TALDO1 dysfunction. The high expression of TALDO1 in the testis and the gonadal failure suggests its tissue specific requirement in preventing the accumulation of ROS during steroidogenesis. Presentation: Monday, June 13, 2022 12:30 p.m. - 2:30 p.m.

Role of Placental Volume Measurement in First Trimester and Uterine Artery Doppler in Second Trimester In The Prediction Of Intra Uterine Growth Retardation And Pregnancy Induced Hypertension

Role of Placental Volume Measurement in First Trimester and Uterine Artery Doppler in Second Trimester In The Prediction Of Intra Uterine Growth Retardation And Pregnancy Induced Hypertension

Feto-maternal outcome of subclinical hypothyroidsm in pregnancy

Introduction : Thyroid dysfunction is one of the most common endocrine disorder affecting women of reproductive age group including pregnancy. There are a few reports of prevalence of hypothyroidism during pregnancy from India with prevalence rate ranging from 4.8% to 11%, Subclinical Hypothyroidism is as high as 13.5 % women. Aim & Objective: To study the incidence of sub clinical hypothyroidism during pregnancy and its outcome both in fetus and mother. Material & Method: This prospective study with 50 patients has been conducted from October 2019 to September 2021, in the department of obstetrics and gynecology at VIMSAR Burla after getting clearance from the institutional ethical committee. Observation: The Incidence of subclinical hypothyroidism was found to be 0.58%. The Common association with maternal complications were preeclampsia (4%), preterm labour (22%), and anti partum haemorrhage (2%).The most common association with neonatal complication observed were low birth weight, intra uterine growth retardation, poor APGAR score, RDS and perinatal deaths. Conclusion: Subclinical hypothyroidism requires special consideration because pregnancy induces major changes in thyroid function and maternal thyroid disease can have adverse effect on pregnancy and fetus. Replacement therapy with L-thyroxin is the treatment of choice in hypothyroidism and subclinical hypothyroidism.

LC/MS/MS assessment of changes in placental angiotensin I metabolism in preeclampsia.

Preeclampsia (PE) is a condition characterized by high blood pressure and significant proteinuria in pregnant women. It affects about 7% pregnancies and can be cause of fetal and maternal morbidity and mortality. During pregnancy, a physiological overexpression of the Renin-Angiotensin System (RAS) components is observed, including increased plasma Ang II level. Dysregulation of RAS in placenta may contribute to preeclampsia and uterine growth retardation. The aim of the study was to evaluate the Ang I metabolism in human preeclamptic placentas and to compare to normal pregnancies condition. Fragments of placental tissues were collected right after ceasarian section from PE and physiological pregnancies. Tissues were incubated in Krebs buffer in the presence of Ang I. Evaluation of Ang I metabolites in incubating fluid was performed by LC/MS/MS method. mRNA expression of main RAS components was measured by RT-PCR. Pattern of angiotensin metabolites did not differ between groups. The main products were Ang 1-7 and Ang II. Comparing to control group, more than 3-fold lower production of Ang II and Ang 1-7 in preeclampsia was observed. mRNA expressions of ACE and AT1 were significantly decreased in pre- eclamptic placentas, whereas higher expression of mRNA of ACE2 and MAS receptor were observed. Production of Ang 1-7 by PE placentas was significantly lower than in control group. Significantly decreased mRNA expression of ACE and AT1 receptor and lower production of Ang II in placentas of PE patients suggest that placental Ang II/ACE/AT1r pathway could be less important than Ang 1-7/ACE-2/MASr pathway in development of preeclampsia, but this requires further investigations.

Yoga During Pregnancy for Healthy Progeny

The World Health Organization defines health is a condition of total physical, mental, and social well-being and body, as well as a healthy mind and spirit, rather than simply the absence of sickness or deformity. Women go through physical, mental, and emotional changes throughout pregnancy. These alterations are a result of pregnancy. These obstacles are exhibited by the joyful condition, tension, and yoga, which helps to calm down and conquer these difficulties. Yoga assists pregnant women in developing a happy mindset and willing to go through the labour procedure. Various Aasanas and breathing exercise revale and decrease the pregnancy related complications like pregnancy induced hypertension, Premature delivery,still birth and intra uterine growth retardation’s. Yoga gives a wide range of activities to the mother and unborn child in different ways. Labor is a time of terror and anguish for the majority of women, and yoga can help them survive with these changes.

Case-Control Study on Fetal Outcomes in Isolated Oligohydramnios in Third Trimester

Background: Oligohydramnios is defined as a condition with low volume of amniotic fluid relative to gestational age. Long-term oligohydramnios can result in pulmonary hypoplasia, intra uterine growth retardation, Potter’s syndrome, club hand & foot and dislocation of hip. This study was conducted to assess feto-maternal outcome in isolated oligohydramnios and factors associated with poor outcome.
 Methodology: This case-control study was conducted from January to December 2020 in the Gynecology & Obstetrics and Radiology departments of HBS General Hospital, Islamabad. Total 300 patients with isolated oligohydramnios fulfilling the criterion were included. For cases, patients with singleton intrauterine pregnancy with AFI <5, of any age or parity with gestational age of more than 34 weeks were included. 300 controls were also taken. Patients with increased amount of amniotic fluid, diabetics, hypertensive and cardiac patients were excluded. Patient were followed up till delivery. Mode of delivery was checked out. Fetal APGAR score at 1 minute and at 5 minutes were observed. New born weight and NICU admissions were recorded. Data was analyzed via SPSS v26.
 Results: Forty six percent (n=138) patients underwent caesarean section while fifty four percent (n=162) had normal vaginal delivery. Significant association (OR=1.85, P<0.001) was found between caesarean section in mothers with oligohydramnios compared to controls. Thirty eight percent (n=114) of neonates among cases had low APGAR score. Significant association (OR=3.29, P<0.001) was found between low APGAR score and mothers with oligohydramnios compare3d to controls. Thirty percent (n=90) required NICU admission. There were 6 still births. Mother’s with oligohydramnios have double risk of still birth and NICU admission compared to women with normal fluid levels.
 Conclusion: Neonate born with mothers having oligohydramnios have low birth weight, lower APGAR scores and high rate of NICU admissions. Delivery at 37-39 weeks in oligohydramnios is associated with higher rate of still births.

Correlation Preterm Infants Gestational Age and Birth Weight at one Medical Center at Banyumas Regency Indonesia

Introduction: Preterm infants commonly experience with low birth weight. Identifying preterm infants’ gestational age and birth weight is pivotal to prevent intra uterine growth retardation and prevent case of LBW infants. Aims: To clarify the correlation between preterm infants’ gestational age and birth weight. Methods: An observational study involving a convenience samples of 46 preterm infants who were born less than 37 weeks gestation were taken from level 1, 2, and 3 neonatal care at one medical center at Banyumas Regency, Indonesia. Data were retrieved from infants’ medical record using a self-designed collection data sheet. Data were analyzed using univariate, Shapiro Wilk, and Spearman Rank test. Result: The preterm infants gestation age had moderate positive correlation with birthweight (r=.490, p= 0.01, n=46). Conclusion: Increasing the maturity of preterm infants’ gestation will effect on the increased of birth weight. It means that health care professional should give health education to mothers to reduce the high risk for preterm infants’ delivery and reduce the risk of LBW infants

Impact of oxidative stress in response to malarial infection during pregnancy: Complications, histological changes, and pregnancy outcomes.

Background and Objectives:Pregnancy malaria is a major underestimated global public health problem. To understand the involvement of oxidative stress (OS) in the pathophysiology of placental malaria, OS biomarkers, malondialdehyde (MDA), uric acid (UA), and superoxide dismutase (SOD) levels were analyzed and correlated to placental histopathological changes and pregnancy outcomes.Methods:A hospital-based study was conducted in Mangaluru, Karnataka, India, to analyze the changes in hematological parameters and the serum OS biomarker levels. Histological analysis of placenta, associated complications, and pregnancy outcomes were compared using Kruskal–Wallis test, and pairwise comparison between two groups was made by Mann–Whitney U-test. Correlations were calculated by Pearson's and Spearman's rank correlations.Results:Among 105 pregnant women, 34 were healthy controls and the infected group comprised of Plasmodium Vivax (Pv) (n = 48), Plasmodium falciparum (Pf) (n = 13), and mixed (n = 10) malaria infections. Of 71 infected cases, 67.6% had mild malaria, whereas 32.4% had severe malaria. The white blood cell and C-reactive protein levels were found to increase, whereas hemoglobin, red blood cell, and platelet levels decreased during both types of malarial infections. The MDA and UA values increased and SOD levels decreased particularly during severe Pf infections. Histological changes such as syncytial knots, syncytial ruptures, and fibrinoid necrosis were observed particularly during Pf infections and leukocyte infiltration was observed in Pv malariaConclusion:Evaluation of MDA, UA, and SOD levels can serve as an indicator of OS during pregnancy malaria. The OS during pregnancy may lead to complications such as severe anemia, pulmonary edema, intra uterine growth retardation, premature delivery, and low birth weight, not only during Pf but also in Pv malaria. It is important to create awareness among rural and immigrant population residing in Mangaluru and its surroundings about required preventive measures and free government-supported antenatal care services.

A Comparative Study to Assess the Knowledge and Attitude Regarding Intra Uterine Growth Retardation and its Prevention Among Antenatal Mothers in Rural and Urban Areas

Intra Uterine Growth Retardation is an important cause of fetal and neonatal morbidity and mortality. The present study was undertaken to compare the knowledge and attitude regarding intra uterine growth retardation and its prevention among antenatal mothers in rural and urban areas Khammam, Telangana. The objectives of the study were to describe the levels of knowledge and attitude, to compare the levels of Knowledge and attitude in rural and urban areas, to find out the association between knowledge and attitude scores with their selected socio-demographic variables. A quantitative survey approach and comparative descriptive design was used for this study. The sample for current study is antenatal mothers who were residing at Raghunadhapalem rural area and Ballepalli urban area, Khammam. The sample size was 100((50 rural+50 urban) and the sample was selected by non-probability convenience sampling technique. Data was collected by using structure interview schedule. The Findings revealed that the knowledge means of antenatal mothers in rural and urban areas were 14.10 and 16.68 respectively. Standard deviations were 3.29 and 3.3 respectively. The ‘t’ calculated value was 3.89 which is significant at 0.05. The attitude means of antenatal mothers in rural and urban areas were 36.08 and 36.02 respectively. Standard deviations were 2.15 and 2.48 respectively. The ‘t’ calculated value was 0.12 which is significant at 0.05. The study concluded that the level of knowledge is low in rural area by comparing with urban area. There is an increased need for awareness program regarding intra uterine growth retardation and its prevention in selected setting in order to promote the health of the fetus and the mother.