Uterine Artery Doppler In Prediction Research Articles

Role of genome damage and Uterine Artery Doppler in prediction of uteroplacental insufficiency

Role of genome damage and Uterine Artery Doppler in prediction of uteroplacental insufficiency

Qual o melhor período para a realização do doppler das artérias uterinas na predição de complicações da gestação?

OBJETIVO: Avaliar, prospectivamente, qual o melhor período para a realização do Doppler das artérias uterinas na predição de complicações da gestação. MATERIAIS E MÉTODOS: Foi conduzido estudo prospectivo em 45 pacientes primigestas, sem história de doenças crônicas. O Doppler das artérias uterinas foi realizado entre 18-20, 24-26, 28-30 e 34-36 semanas, com determinação do índice de resistência, índice de pulsatilidade, relação A/B e a presença ou ausência de incisura na onda de velocidade de fluxo, assim como o resultado da gestação. RESULTADOS: Os índices Doppler apresentaram decréscimo com o decorrer da gestação, mais pronunciado nas gestações normais quando estas foram comparadas com aquelas que tiveram complicações, de maneira mais acentuada no exame realizado entre 24-26 semanas. A melhor relação entre sensibilidade e especificidade para a detecção de complicações durante a gestação foi obtida no exame realizado entre 24-26 semanas. CONCLUSÃO: O melhor período para a realização do Doppler das artérias uterinas na predição de complicações da gestação é o intervalo entre 24-26 semanas.

Combining 2nd-Trimester Maternal Serum Homocysteine Levels and Uterine Artery Doppler for Prediction of Preeclampsia and Isolated Intrauterine Growth Restriction

Aim: To evaluate the efficacy of a combined 2nd-trimester maternal serum homocysteine and uterine artery Doppler screening at 20 weeks of gestation for complications of pregnancy: preeclampsia, isolated intrauterine growth restriction (IUGR), placental abruption, and stillbirths. Methods: Consecutive singleton pregnancies without previous risk factors who had homocysteine measured as part of a serum-screening program for trisomy 21 had uterine artery Doppler performed. Sensitivity, specificity, positive and negative predictive values, odds ratio, and positive and negative likelihood ratios for the subsequent development of preeclampsia, isolated IUGR, placental abruption, stillbirth, and preterm delivery were calculated for the following methods (1) homocysteine cutoff level 6.3 µmol/l (95th centile); (2) on Doppler ultrasound bilateral notches with a mean resistance index (RI) >0.55 (50th centile), all unilateral notches with a mean RI >0.65 (80th centile), and absence of notches with a mean RI >0.7 (95th centile), and (3) Doppler ultrasound notch evaluation (bilateral, unilateral, absence as in method 2) combined with the homocysteine cutof level of 6.3 µmol/l. Results: By using a logistic regression model, methods 1 and 2 predicted preeclampsia (p < 0.001), isolated IUGR (p < 0.01), and ‘any complication’ (p < 0.01). The sensitivity for prediction of preeclampsia using the combined method (3) was 61.3% for a false-positive rate of 2%, better than that for isolated IUGR (54%) below the 5th centile and ‘any complication’(56%). Conclusion: This prospective study confirms the potential of a combined method of elevated homocysteine and uterine artery Doppler screening for preeclampsia, isolated IUGR, and any obstetric complication.

The clinical value of combining maternal serum screening and uterine artery Doppler in prediction of adverse pregnancy outcome

SummaryUterine artery Doppler waveform analysis is not offered in routine antenatal care in the UK. The aim of this study is to evaluate a policy of offering uterine artery Doppler ultrasound, in the setting of a District General Hospital, to women who are judged to be at high risk of adverse pregnancy outcome, based on their mid-trimester biochemical serum screening. Data from 73 cases with abnormal serum screening were collected and analysed. Abnormal outcome occurred in 11 cases (16%) including two perinatal deaths. The positive predictive value of adverse outcome was 13% for abnormal serum screening, 26% for human chorionic gonadotropin (hCG) >3 multiples of the median (MOM) and 8% for alfa-fetoprotein (AFP) >2.5 MOM. A total of 56 cases of the study group had uterine artery Doppler at 22 weeks' gestation. Evaluation of the performance of uterine artery Doppler in prediction of adverse pregnancy outcome revealed a sensitivity of 43%, specificity of 70%, a positive predictive value (PPV) of 18% and a negative predictive value (NPV) of 89%. When the presence of diastolic notch was taken to define a positive result the sensitivity remained unchanged, however the specificity, PPV and NPV improved to 91%, 43% and 91%, respectively. In conclusion, the combination of serum markers and abnormal uterine artery Doppler ultrasound improves the identification of women at risk of subsequent pregnancy complications. Raised serum hCG has a better predictive value for adverse pregnancy outcome as opposed to raised serum AFP. In the absence of diastolic notch, the accuracy of abnormal uterine artery Doppler ultrasound is markedly reduced.