The treatment of deep skin lesions is a pressing issue in modern medicine. Using chinchilla rabbits, we examined the effect of multilayer dressings with ordered periodic structure on the regeneration of skin covered with deep skin lesions. On the back of all animals, fascias (size up to 40 × 40 mm) were dissected. In rabbits (from experimental group I), the wound dressing was composed of a plate of fish (carp) scales (multilayer biogenic structure). In rabbits (from experimental group II), the wound dressing was composed of 50 lavsan films metallized by a nanodimensional layer of aluminum. In the control group, wound dressings were composed of a thin plate of Teflon or aluminum (one layer). In all rabbits of the control group, purulonecrotic processes were developed within 1–2 weeks. In all rabbits of the experimental groups, the repair of the wound proceeded without any clinical signs of inflammation during the whole period of observation. In the experimental animals, within 6 weeks, the deep skin lesions had fully healed, and the area of the skin defects had a thickness and structure characteristic of normal skin. The multilayer principle may be promising for the development of dressings for the treatment of deep but small skin wounds of different etiology in cases when high quality dermal regeneration is needed.