Climate change impact serious threats to global food security due to changes in water requirements resulting from the variation and instability of the spatial and temporal distribution of rainfall and the lack of water availability. Therefore, our research aims to use anti-transpiration agents that reduce plant water consumption, thus providing adequate amounts of water for agriculture in arid areas. A field experiment was conducted under water stress conditions during the winter seasons 2022-2023 and 2023-2024. The study included three levels of water stress, which are depletion of 40, 55 and 70% of the available water at a depth of 20 cm for the first three irrigations and a depth of 30 cm for the remaining irrigations and for the three treatments in succession. Anti-transpiration was added from different sources, which are kaolin, paraffin wax, silicon and potassium, in addition to the comparison treatment (spraying with water only). The results showed significant differences between the depletion treatments, as the 40% depletion treatment of the available water was significantly superior in most of the characteristics of the crop and its components, as the amount of increase in the grain yield was 62.24 and 64.22% for the two seasons in succession, compared to the 70% depletion treatment of the available water, which gave the lowest averages for all the studied characteristics. The irrigation treatment after depleting 40% of the available water was characterized by the best water use efficiency of 1.60 and 1.44 kg m-3 for the two seasons respectively, compared to the treatment of depleting 70% of the available water, which gave the lowest water use efficiency of 1.14 and 1.02 kg m-3 for the two seasons respectively. Spraying with anti-transpiration and potassium led to a significant increase in the yield and all its components compared to the comparison treatment (spraying with water only), which gave the lowest averages for all the studied traits, as spraying with potassium and kaolin gave a significant increase in most of the studied traits. Also, anti-transpiration and potassium, represented by potassium and kaolin, had a significant effect on water use efficiency, as the increase amount when spraying with potassium was 45.87 and 46.93% for the two seasons respectively compared to the comparison treatment (spraying with water only). As for the actual water consumption, we find an increase in the values of water consumption and the number of irrigations in the comparison treatment (spraying with water only) compared to the anti-transpiration and potassium treatments, as the anti-transpiration and potassium provided water at a depth of 550, 414 and 405 m3 ha-1 for the first season and 615, 375 and 393 m3 ha-1 for the second season for the depletion treatments of 40, 55 and 70% of the available water, respectively, compared to the comparison treatment (spraying with water only). This increase is not small when applied to large areas and providing additional agricultural areas that can be invested. These findings suggest that targeted use of these treatments can effectively mitigate the effects of water stress, improving wheat production and resource efficiency in water-limited environments.