Objective: To describe a rare case of intramural pregnancy diagnosed with the use of magnetic resonance imaging (MRI) and conservatively managed. Design: Case report. Setting: Department of obstetrics and gynecology in a university hospital. Patient: A 33-year-old healthy patient with a history of a partial mole after 3 years of primary unexplained infertility. Intervention(s): Laparoscopic and transvaginal local injections of methotrexate. Main Outcome Measure(s): Transvaginal ultrasound (US) and MRI findings. Result: Treatment was successful, with no complications, and the patient’s reproductive potential was preserved. Conclusion(s): Early detection of intramural pregnancy with the use of transvaginal US is important, and MRI is a useful, noninvasive imaging modality. Chemotherapy with methotrexate is an effective treatment that allows preservation of reproductive potential.