Use Of Traditional Remedies Research Articles

Role of free radicals in the neurodegenerative diseases: therapeutic implications for antioxidant treatment.

Free radicals and other so-called 'reactive species' are constantly produced in the brain in vivo. Some arise by 'accidents of chemistry', an example of which may be the leakage of electrons from the mitochondrial electron transport chain to generate superoxide radical (O2*-). Others are generated for useful purposes, such as the role of nitric oxide in neurotransmission and the production of O2*- by activated microglia. Because of its high ATP demand, the brain consumes O2 rapidly, and is thus susceptible to interference with mitochondrial function, which can in turn lead to increased O2*- formation. The brain contains multiple antioxidant defences, of which the mitochondrial manganese-containing superoxide dismutase and reduced glutathione seem especially important. Iron is a powerful promoter of free radical damage, able to catalyse generation of highly reactive hydroxyl, alkoxyl and peroxyl radicals from hydrogen peroxide and lipid peroxides, respectively. Although most iron in the brain is stored in ferritin, 'catalytic' iron is readily mobilised from injured brain tissue. Increased levels of oxidative damage to DNA, lipids and proteins have been detected by a range of assays in post-mortem tissues from patients with Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis, and at least some of these changes may occur early in disease progression. The accumulation and precipitation of proteins that occur in these diseases may be aggravated by oxidative damage, and may in turn cause more oxidative damage by interfering with the function of the proteasome. Indeed, it has been shown that proteasomal inhibition increases levels of oxidative damage not only to proteins but also to other biomolecules. Hence, there are many attempts to develop antioxidants that can cross the blood-brain barrier and decrease oxidative damage. Natural antioxidants such as vitamin E (tocopherol), carotenoids and flavonoids do not readily enter the brain in the adult, and the lazaroid antioxidant tirilazad (U-74006F) appears to localise in the blood-brain barrier. Other antioxidants under development include modified spin traps and low molecular mass scavengers of O2*-. One possible source of lead compounds is the use of traditional remedies claimed to improve brain function. Little is known about the impact of dietary antioxidants upon the development and progression of neurodegenerative diseases, especially Alzheimer's disease. Several agents already in therapeutic use might exert some of their effects by antioxidant action, including selegiline (deprenyl), apomorphine and nitecapone.

A description of child illness and treatment behavior in Guatemala

This paper uses a new calendar design implemented in the Guatemalan Survey of Family Health to analyze diarrheal and respiratory illness among children. The calendar provides a much richer description of child illness and treatment behavior than do conventional data typically collected in health interview surveys. The resulting estimates reveal that Guatemalan children experience high rates of diarrheal and respiratory illness and that these illnesses often involve multiple symptoms that only partially overlap one another. In addition, estimates from the calendar demonstrate that the measurement of illness frequency is fairly complex and that classification of illness into distinct categories may not always be feasible or meaningful. Results regarding treatment behavior indicate that the vast majority of illnesses are treated and that mothers almost always receive advice regarding their children’s illnesses from relatives. On the other hand, health providers are sought for advice and treatment in only about one-third of illnesses. When families do seek providers, they are more likely to rely on biomedical ones — especially pharmacists, doctors and personnel at health posts and centers — than traditional practitioners. By far, the most common form of treatment — recommended by both relatives and providers — consists of readily available Western medicines. In contrast, the use of traditional remedies appears to be relatively low.

Concentration of blood lead and ethnicity in the United Kingdom.

The relation between concentration of blood lead and ethnic background in 779 children was examined with the analytical results from the trace element service at the Medical Toxicology Unit (MTU), Guy's and St Thomas's Hospital Trust for the period 1980-94. The ethnic identity was determined with the first and the second names of the investigated subjects. Of the patients of European origin (European) studied 72.8% v only 50.6% of the children with origins in the Indian subcontinent (Asian) had a concentration of blood lead < 100 micrograms/l. The percentage of subgroups with concentrations above the upper acceptable limit of 200 micrograms/l was significantly higher in Asian subjects (European 5% v Asian 26.5%), with the most pronounced difference in those with concentrations of blood lead of 500 micrograms/l (European 0.8% v Asian 10.5%). This study shows that a correlation exists between Asian ethnic background and concentration of blood lead in children. Factors such as cultural habits-for example, use of traditional remedies, cosmetics, diet- and socioeconomic status, may have contributed to this results.

Malaria remedies of the Kenyah of the Apo Kayan, East Kalimantan, Indonesian Borneo: A quantitative assessment of local consensus as an indicator of biological efficacy

Traditional remedies have been a source of important antimalarial drugs and continue to provide novel and effective treatments, both where pharmaceuticals are not available and where the disease is increasingly resistant to commonly prescribed drugs. The Kenyah of the Apo Kayan, a remote forested plateau in Indonesian Borneo, use 17 malaria remedies derived from natural sources. A quantitative analysis of the relationship between a ‘local importance value’ index for each malaria remedy (IV mal) and inhibition of cultured Plasmodium falciparum by ethanolic extracts supports the hypothesis that the degree of local consensus about a given remedy is a good indicator of its potential biological efficacy. Our results confirm the rational selection and use of traditional remedies for malaria by the Kenyah. We have identified target species for further research directed toward safe and effective treatments for malaria.

Home remedies and doctors' remedies in Feira (Brazil)

The analysis of popular notions and practices concerning home remedies and pharmaceutical drugs in Feira (Brazil) provides an opportunity to examine the interface, both complementary and conflictual, of different medical traditions. The popular use of drugs is in part modelled after the popular use of traditional remedies and both uses are largely influenced by the epidemiological profile of the community, by local notions of illness and therapeutic efficacy, financial constraints and medicalization processes. The usage of these remedies is also analyzed as a practical logic of popular culture.

Distribution of blood lead levels in 1,047 Saudi Arabian children with respect to province, sex, and age.

Relationships between blood lead concentrations in 1,047 children aged 2 mo to 16 y and age, sex, and province (i.e., residence) were examined. The relationships were consistent with other studies, in which mean blood lead concentrations reportedly increased during the first 5 y of life, after which began to decrease, reaching a minimum at approximately 16 y of age. However, boys who were more than 6 y of age had higher blood lead concentrations than similarly aged girls. Blood lead levels of children living in the Eastern Province were higher than levels found in children from other provinces. Most of the children in this study who had elevated blood lead concentrations resided in small towns, e.g., Ehssa, Abqiq, Hofouf, rather than in cities such as Dammam and Dahran. Factors, such as socioeconomic status and cultural habits (e.g., diet, use of traditional remedies and cosmetics), may have contributed to this result.

Safer use of traditional remedies

Don't generalise about traditional remedies EDITOR,--David J Atherton's article on traditional remedies makes repeated generalisations about these remedies, their practitioners, and patients.1 He states that “when people from less developed countries emigrate they continue to seek medical advice from traditional practitioners” and that “large amounts of traditional medicine are imported into Britain,” but he …

Hearing impairment and ear pathology in Nepal

A stratified random cluster sample of 15,845 subjects was performed in two regions of Nepal to determine the prevalence and main causes of hearing impairment (the most common disability) and the prevalence of ear disease. Subjects reporting current ear pain, or ear discharge, or hearing impairment on direct questioning by a Nepali health worker (primary screening failed), had otoscopy and audiometry (using the Liverpool Field Audiometer) performed, and a questionnaire administered relating to past history. In every fifth house subjects who passed the primary screening (1,716 subjects) were examined to assess the false negative rate of screening. An estimated 16.6 per cent of the study population have hearing impairment (either ear worse than 30 dB hearing threshold level (HTL) 1.0-4.0 kHz, or 50 dB HTL 0.5 kHz), and 7.4 per cent ear drum pathology, equivalent to respectively 2.71 and 1.48 million people extrapolated to the whole of Nepal. Most hearing impairment in the school age group (55.2 per cent) is associated with otitis media or its sequelae. Probably at least 14 per cent of sensorineural deafness is preventable (7 per cent infectious disease, 3.9 per cent trauma, 0.8 per cent noise exposure, 1 per cent cretinism, and 1 per cent abnormal pregnancy or labour). Most individuals reporting current ear pathology (61 per cent) had never attended a health post, and of those receiving ear drop treatment, 84 per cent still had serious pathology. Of subjects who reported ear drop treatment at any time, 31 per cent still had serious pathology. The use of traditional remedies was prevalent.(ABSTRACT TRUNCATED AT 250 WORDS)