Use Of Thiourea Research Articles

Thiouracil Treatment in Hyperthyroidism1

IT HAS NOW BEEN well established that the endocrine function of the thyroid gland can be inhibited by the administration of thiouracil. In several species of experimental animals large doses induce a state of hypothyroidism equivalent to that following complete surgical ablation of the gland while in human beings hyperthyroidism is effectively controlled by the continued administration of relatively small amounts (1). Additional information on the clinical use of thiourea and thiouracil is being obtained and preliminary reports have appeared from several clinics. Himsworth (2) has reported six cases treated successfully with thiourea; Williams and G. Bissell (3) treated nine and Palmer (4) twelve cases with thiouracil and Rawson and his collaborators (5) have used thiouracil to prepare nineteen cases of thyrotoxicosis for surgery. Sloan and Shorr (6) have recorded twelve cases treated with thiouracil and have demonstrated that all of the common metabolic derangements of hyperthyroidism are corrected by th...

Thiourea and Thiouracil in Treatment of Thyrotoxicosis1

SULFONAMIDES, thiourea and a number of other compounds have been found to suppress thyroid activity in experimental animals (1, 2). These drugs act by suppressing formation of thyroxin (1–5). Astwood, after a study of about 120 compounds (6), used two—thiourea and thiouracil—for treatment of patients with thyrotoxicosis (7). Williams and Bissell (8) have reported nine cases treated with thiouracil; Hims worth (9) has reported six cases treated with thiourea. We are reporting here our experience with the use of thiourea and thiouracil3 in 21 patients with thyrotoxicosis. MATERIAL The pertinent clinical data are summarized the accompanying table. RESULTS OF TREATMENT Results were gauged by general clinical improvement—disappearance of nervousness, vasomotor instability, tremor and sweating, by return of pulse rate and BMR to normal values, and by weight increase. The serum cholesterol value was determined in the majority of cases. All patients responded favorably with the exception of Case 2, in which treat...

Quinaldinic acid as a micro-reagent

A method for the micro-estimation of zinc by means of quinaldinic acid in the presence of copper, silver or mercury individually, or in the presence of both silver and mercury, is described. It depends upon the use of thiourea for masking the reaction of copper, mercury and silver ions with which it forms stable complexes in acid solution. In the case, where copper is present, a previous addition of sodium bisulphite is necessary to reduce the cupric to cuprous ion. Zinc is precipitated as usual in acetic acid solution by the addition of sodium quinaldinate.