The use of real-world data (RWD) warehouses for research in Asia is on the rise, but current trends remain largely unexplored. Given the varied economic and healthcare landscapes among various Asian countries, understanding these trends can offer valuable insights. We sought to discern the contemporary landscape of linked RWD databases and explore their trends and patterns in three Asian countries with contrasting economies and healthcare systems: Taiwan, India, and Thailand. Utilising a systematic scoping review methodology, we conducted an exhaustive literature search on PubMed with filters for the English language and the last five years. The search combined MeSH terms and specific keywords. Following this, studies were screened against strict eligibility criteria, to identify eligible studies utilising various real-world research databases from more than one healthcare facility in at least one of the three target countries. Our search yielded 2277 studies, of which 833 met our criteria. Overall, there seemed a dominance of single-country studies (SCS) at 89.4% and cross-country collaboration studies (CCCS) at 10.6%. However, the country-wise breakdown showed that of all the SCS, 623 (74.7%) were from Taiwan, 81 (9.7%) from India, and 41 (4.9%) from Thailand. India and Thailand participated in much higher number of CCCS than Taiwan (39%, 43% and 7.6%, respectively). Over a five-year span from 2017-2022, India and Thailand also experienced an annual increase in RWD studies by approximately 18% and 14% respectively, while Taiwan's contributions remained consistent.Comparative effectiveness Research (CER) was predominant in Taiwan (66% of SCS), but less common in India (15%) and Thailand (27%). CER percentages in CCCS were similar across the three countries, ranging from 19%-29%. The type of RWD source also varied significantly across countries, with India demonstrating a high reliance on Electronic Medical Records (EMR) or Electronic Health Records (EHR) at 56%, and Taiwan showing an increasing trend in its use over the period. Registries were used in >80% of CCCS and 79% of Thailand SCS but in <50% of SCS from Taiwan and India. Claims data was used in most of Taiwan SCS (74%). A consistent observation was the predominant focus on cardiology/metabolic disorders in all studies, with a noticeable increase in oncology and infectious diseases research from 2017 to 2022. Other findings highlighted variations in study durations, publication time lags, and mean study sample sizes across countries and study types. This review provides a comprehensive understanding of the evolving landscape of RWD research in Taiwan, India, and Thailand. The observed differences and trends emphasise the unique economic, clinical, and research settings in each country, advocating for tailored strategies in leveraging RWD for future healthcare research and decision-making. Rr2-10.2196/43741.