The partner in this service is a plastic screen printing business. The number of participants in the activity was 10 screen printing workers. Lectures, discussions, and simulations carry out the method of activity. Data collection techniques through pre and post-test questionnaires conducted before and after socialization activities and simulated use of personal protective equipment. This advocacy activity is carried out on screen printing business owners, aiming to get support from screen printing business owners to participate in preventing the risk of chemical exposure to screen printing workers and screenprinting business owners welcome enthusiastically and participate in service activities. Socialization activities to measure success by conducting pretest and posttest with pretest and posttest results increased the average value according to the target, which was 51%. Workers are also given a simulation of the use of personal protective equipment in the form of a respirator so that they can apply the use of a respirator correctly. The results of assistance after the activity was carried out, all workers had used personal protective equipment in the form of respirators while working to prevent the risk of exposure to chemicals used as screen printing materials. Workers' knowledge of hazards and their control increased by 51% and workers have used personal protective equipment properly to prevent the risk of hazards that arise when working with plastic screen printing worker