Use Of PCP Research Articles

Use of psychoactive substances by goods carriage drivers associated with Kerala, India

Objective This study aimed to measure the prevalence of drugs of abuse (DOA) among the goods carriage drivers associated with the southern State of India, Kerala. Methods Point-of-collection testing (POCT) of oral fluid collected from the participants (n = 249) was done using the Evidence MultiSTAT DOA Oral Fluid II Assay kits and the Evidence MultiSTAT analyzer. Results Out of the total samples, 53 (21.29%) were positive for one or more DOA. A high prevalence of tetrahydrocannabinol (THC) (10.04%) and synthetic cannabinoids were detected in the samples. The use of ketamine, alpha-PVP, LSD, methamphetamine, opiate, 6-MAM, benzodiazepines I, methadone, PCP, tramadol, and amphetamine was also detected and their frequency of use ranged between 4.02 and 0.80%. An association between drug abuse and distance of travel was found in drivers in this study, χ 2 (5, N = 249) = 123.5, p < 0.001. Confirmatory analysis using ultra-high performance liquid chromatography-tandem mass spectrometry showed excellent agreement with the results of the screening test. Conclusions This was the first study conducted among drivers in India for the detection of DOA. Tetrahydrocannabinol (THC) was used more by the goods carriage drivers associated with Kerala State, India. The use of psychoactive substances significantly increased with the distance of travel. Point-of-collection testing (POCT) by the biochip array technology is an efficient method for the detection of these substances.

Adolescent and adult time trends in US hallucinogen use, 2002-19: any use, and use of ecstasy, LSD and PCP.

Hallucinogen use is potentially harmful. Information on whether such use has increased in recent decades is lacking. This study assessed overall and age-specific time trends in the prevalence of 12-month hallucinogen use in the US general population. Cross-sectional. Data from the US National Survey on Drug Use and Health, 2002-19. Respondents aged ≥ 12 years (n = 1 006 051). Predictors were continuous years. Outcome variables included any hallucinogen use and use of lysergic acid diethylamide (LSD), ecstasy and phencyclidine (PCP) in the past year. Socio-demographic variables (gender, age, race/ethnicity, educational level and family income) were covariates. Overall, hallucinogen use increased between 2015 and 2019 [prevalence difference (PD) = +0.44, P< 0.05]. Since 2002, hallucinogen use has increased in adults aged ≥ 26 years (PD, 2002-14 = +0.24, P< 0.05; PD, 2015-19 = +0.45, P< 0.001) and decreased in adolescents aged 12-17 years (PD, 2002-14 = -1.60, P< 0.0001; PD, 2015-19 = -0.73, P< 0.001). Ecstasy use has decreased in adolescents (PD, 2002-14 = -0.56, P< 0.001), adults aged 18-25 years (PD, 2015-19 = -0.96, P< 0.01) and ≥ 26 years (PD, 2015-19 = -0.13, P< 0.05). LSD use between 2002 and 2019 increased overall (PD = +0.71, P< 0.0001) and in all age groups (12-17: PD = +0.67, P< 0.001; 18-25: PD = +3.12, P< 0.0001; ≥ 26: PD = +0.36, P< 0.0001). Conversely, PCP use between 2002 and 2019 decreased overall (PD = -0.06, P< 0.001), in adolescents (PD = -0.24, P< 0.001) and young adults (PD = -0.32, P< 0.0001). Since 2002, hallucinogen use in the United States has decreased among adolescents but increased in adults and is now estimated to affect more than 3 million adults aged 26+ years and more than 5.5 million adults aged 18+ years.

Association of self-reported personal care product use with blood glucose levels measured during pregnancy among women from a fertility clinic

BackgroundPersonal care products (PCPs), known sources of endocrine disrupting chemicals (EDCs) such as phthalates and parabens, are widely used among women of reproductive age. EDCs have been linked to pregnancy complications such as gestational diabetes (GDM), and PCP use could represent a modifiable source of exposure in this sensitive time window. Yet, to our knowledge, no study has directly evaluated the association between pregnancy use of PCP and late pregnancy glucose levels, established risk factors for complications such as GDM. MethodsA total of 233 women from the Environment and Reproductive Health (EARTH) Study had data available on 1st and/or 2nd trimester PCP use, assessed through self-reported use over the previous 24 h, and blood glucose levels after the glucose loading test (GLT), taken at late 2nd trimester. Associations between each individual PCP and total PCP with glucose levels were evaluated in multivariable adjusted linear regression models. ResultsBoth positive and negative differences in glucose levels were observed when comparing users vs. non-users of several PCPs including 2nd trimester use of deodorant (adjusted mean difference: 12.2 mg/dL, 95% CI: −0.6, 24.9); bar soap (6.9 mg/dL, 95% CI: −0.9, 14.7 mg/dL); and liquid soap (−13.3, 95% CI: −26.8, 0.1 mg/dL), and 1st trimester use of sunscreen (−14.6 mg/dL, 95% CI: −27.8, −1.5 mg/dL). Total number of PCPs used in the 2nd trimester was also associated with higher glucose levels, with the largest difference of 20 mg/dL when comparing individuals who used eight vs none PCPs (95% CI: 3–37). ConclusionsIn a pregnancy cohort of women seeking care at a fertility clinic, we found the use of several PCPs to be positively or negatively associated with glucose levels in the late second trimester, which may reflect increased risk of GDM and subsequent perinatal outcomes. These results strengthen the role of product use as a potentially modifiable source of EDCs that may impact glucose levels.

PCDD/Fs and dl-PCBs concentrations in water samples of Taiwan

Polychlorinated dibenzo-p-dioxins (PCDDs), dibenzofurans (PCDFs) and coplanar polychlorinated biphenyls (dioxin-like PCBs) have received much public concern worldwide due to their persistence and toxicity. The presence of these compounds in environmental matrices, especially in water bodies, enhances the risk of human exposure to these toxic pollutants. In this study, seventeen 2,3,7,8 chlorinated PCDD/Fs and twelve dl-PCBs were measured in 11 groundwater samples collected throughout Taiwan and 2 surface water samples collected in northern Taiwan. PCDD/F and PCB concentrations in two surface water samples are relatively low, with the average concentrations of 0.038 and 0.001 pg WHO-TEQ/L (7.474 and 1.862 pg L−1), respectively. As for groundwater samples, PCDD/F concentrations measured range from 0.005 to 3.963 pg WHO-TEQ/L, while dl-PCB concentrations range from 2.5 × 10−5 to 0.189 pg WHO-TEQ/L. Total WHO-TEQ concentrations range from 0.005 to 3.963 pg WHO-TEQ/L, reflecting serious contamination of PCDD/Fs and PCBs in groundwater at some sampling sites. In term of total PCDD/Fs, PCDDs constitute a significant fraction (77.3%), and OCDD is most abundant, followed by HpCDD/Fs and HxCDD/Fs. PCB 118 is dominant among 12 dl-PCBs measured, followed by PCB 105 and PCB 77. Solid-phase PCDD/Fs generally predominate in water samples and PCDFs are of slightly lower distribution in solid phase in comparison with PCDDs, while PCBs are mainly distributed in dissolved phase. Results of principal component analysis (PCA) indicate that use of PCP and Na-PCP, thermal processes and PCBs-containing products might be the major sources of PCDD/Fs and PCBs in water samples measured.

The impact of pre-injury controlled substance use on clinical outcomes after trauma.

A disproportionately high percentage of trauma patients use controlled substances, and they often co-ingest multiple drugs. Previous studies have evaluated the effect of individual drugs on clinical outcomes after trauma. However, the impact of all drugs included in a comprehensive screening panel has not yet been compared in a single cohort of patients. All trauma patients who underwent urine drug screens after admission to the LAC + USC Medical Center (January 2008-June 2015) were identified retrospectively. Univariable and multivariable regression analyses determined the significance of all drugs tested in the hospital's standard toxicology screen (amphetamine, barbiturate, benzodiazepine, cocaine, opiate, phencyclidine) on clinical outcomes. A total of 10,166 patients who underwent admission toxicology screening were identified. Although 5,621 patients had completely negative screens, 3,292 patients tested positive for only one drug and 1,253 patients tested for multiple drugs. Univariable analysis indicated that patients who tested positive for multiple drugs had higher rates of operative intervention (p < 0.001), longer hospital stay (p < 0.001), and longer ICU stays (p < 0.001). Multivariable analysis indicated that phencyclidine was associated with higher rates of mortality (p = 0.025) whereas amphetamine was associated with lower rates of mortality (p = 0.012). Higher rates of operative intervention were observed in patients testing positive for amphetamine (p < 0.001), benzodiazepine (p < 0.001), or opiate (p < 0.001). Benzodiazepine use was associated with higher rates of mechanical ventilation (p < 0.001), but use of amphetamines (p = 0.021) or opiates (p < 0.001) was associated with lower rates. Pre-injury use of amphetamine, barbiturate, benzodiazepine, cocaine, opiate, and PCP has a significant and variable impact on clinical outcomes after trauma. Comparing the relative effect of each drug class can help clinicians risk-stratify all trauma patients, including those who test positive for multiple substances. Epidemiologic study, level III.

Sparse approximation is provably hard under coherent dictionaries

It is well known that sparse approximation problem is NP-hard under general dictionaries. Several algorithms have been devised and analyzed in the past decade under various assumptions on the coherence μ of the dictionary represented by an M×N matrix from which a subset of k column vectors is selected. All these results assume μ=O(k−1). This article is an attempt to bridge the big gap between the negative result of NP-hardness under general dictionaries and the positive results under this restrictive assumption. In particular, it suggests that the aforementioned assumption might be asymptotically the best one can make to arrive at any efficient algorithmic result under well-known conjectures of complexity theory. In establishing the results, we make use of a new simple multilayered PCP which is tailored to give a matrix with small coherence combined with our reduction.

Histamine H3 receptor antagonists display antischizophrenic activities in rats treated with MK-801.

Animal models based on N-methyl-d-aspartate receptor blockade have been extensively used for schizophrenia. Ketamine and MK-801 produce behaviors related to schizophrenia and exacerbated symptoms in patients with schizophrenia, which led to the use of PCP (phencyclidine)- and MK-801 (dizocilpine)-treated animals as models for schizophrenia. The study investigated the effect of subchronic dosing (once daily, 7 days) of histamine H3 receptor (H3R) antagonists, ciproxifan (CPX) (3 mg/kg, i.p.), and clobenpropit (CBP) (15 mg/kg, i.p.) on MK-801 (0.2 mg/kg, i.p.)-induced locomotor activity and also measured dopamine and histamine levels in rat's brain homogenates. The study also included clozapine (CLZ) (3.0 mg/kg, i.p.) and chlorpromazine (CPZ) (3.0 mg/kg, i.p.), the atypical and typical antipsychotic, respectively. Atypical and typical antipsychotic was used to serve as clinically relevant reference agents to compare the effects of the H3R antagonists. MK-801 significantly increased horizontal locomotor activity, which was reduced with CPX and CBP. MK-801-induced locomotor hyperactivity attenuated by CPX and CBP was comparable to CLZ and CPZ. MK-801 raised striatal dopamine level, which was reduced in rats pretreated with CPX and CBP. CPZ also significantly lowered striatal dopamine levels, although the decrease was less robust compared to CLZ, CPX, and CBP. MK-801 increased histamine content although to a lesser degree. Subchronic treatment with CPX and CBP exhibited further increased histamine levels in the hypothalamus compared to MK-801 treatment alone. Histamine H3 receptor agonist, R-α methylhistamine (10 mg/kg, i.p.), counteracted the effect of CPX and CBP. The present study shows the positive effects of CPX and CBP on MK-801-induced schizophrenia-like behaviors in rodents.

Postnatal Phencyclidine (PCP) as a Neurodevelopmental Animal Model of Schizophrenia Pathophysiology and Symptomatology: A Review.

Cognitive dysfunction and negative symptoms of schizophrenia remain an unmet clinical need. Therefore, it is essential that new treatments and approaches are developed to recover the cognitive and social impairments that are seen in patients with schizophrenia. These may only be discovered through the use of carefully validated, aetiologically relevant and translational animal models. With recent renewed interest in the neurodevelopmental hypothesis of schizophrenia, postnatal administration of N-methyl-D-aspartate receptor (NMDAR) antagonists such as phencyclidine (PCP) has been proposed as a model that can mimic aspects of schizophrenia pathophysiology. The purpose of the current review is to examine the validity of this model and compare it with the adult subchronic PCP model. We review the ability of postnatal PCP administration to produce behaviours (specifically cognitive deficits) and neuropathology of relevance to schizophrenia and their subsequent reversal by pharmacological treatments. We review studies investigating effects of postnatal PCP on cognitive domains in schizophrenia in rats. Morris water maze and delayed spontaneous alternation tasks have been used for working memory, attentional set-shifting for executive function, social novelty discrimination for selective attention and prepulse inhibition of acoustic startle for sensorimotor gating. In addition, we review studies on locomotor activity and neuropathology. We also include two studies using dual hit models incorporating postnatal PCP and two studies on social behaviour deficits following postnatal PCP. Overall, the evidence we provide supports the use of postnatal PCP to model cognitive and neuropathological disturbances of relevance to schizophrenia. To date, there is a lack of evidence to support a significant advantage of postnatal PCP over the adult subchronic PCP model and full advantage has not been taken of its neurodevelopmental component. When thoroughly characterised, it is likely that it will provide a useful neurodevelopmental model to complement other models such as maternal immune activation, particularly when combined with other manipulations to produce dual or triple hit models. However, the developmental trajectory of behavioural and neuropathological changes induced by postnatal PCP and their relevance to schizophrenia must be carefully mapped out. Overall, we support further development of dual (or triple) hit models incorporating genetic, neurodevelopmental and appropriate environmental elements in the search for more aetiologically valid animal models of schizophrenia and neurodevelopmental disorders (NDDs).

Pentachlorophenol removal by Rhizopus oryzaeCDBB‐H‐1877 using sorption and degradation mechanisms

AbstractBACKGROUNDPentachlorophenol (PCP) is a pollutant of soil and water and it is very toxic to humans and aquatic life. The use of PCP is now restricted or prohibited in development countries, but many areas of the world remain contaminated. Fungi, mainly basidiomycetes, have been studied as a means to remove PCP. However, little is known of the mechanisms used by zygomycetes to remove PCP.RESULTSThe effect of two initial amounts of PCP and of two carbon and nitrogen sources on the metabolic response was assayed by determining kinetic and stoichiometric parameters of fungal growth, intermediates, sorption capacity, and abiotic losses of PCP. Independently from carbon sources, sorption was observed. Cultures with glucose–ammonium sulfate and 2 mg PCP yielded 0.116 µg of pentachloroanisole and 10.46 µg of chlorinated compounds. Cultures with glutamic acid–sodium nitrate and 2 mg PCP yielded 6.81 µg of pentachloroanisole and 2.89 µg of chlorinated compounds. Other unidentified metabolites were produced, some of them probably at high concentration.CONCLUSIONSorption is the principal mechanism used by Rhizopus oryzae CDBB‐H‐1877 to remove PCP from culture broth. However, a small fraction of sorbed PCP is degraded by means of methylation and dechlorination reactions. This biodegradation is mainly intracellular and depends on the carbon source. © 2014 Society of Chemical Industry

The new drug phenomenon

The new drug phenomenon

Predicting High Risk Adolescents’ Substance Use Over Time: The Role of Parental Monitoring

We examined whether parental monitoring at baseline predicted subsequent substance use in a high-risk youth population. Students in 14 alternative high schools in Washington State completed self-report surveys at three time points over the course of 2 years. Primary analyses included 1,423 students aged 14-20 who lived with at least one parent or step-parent at baseline. Using hierarchical linear modeling, we found that high parental monitoring at baseline predicted significantly less use of alcohol, marijuana, downers, cocaine, PCP, LSD, and prescription drugs and drinking to intoxication at the first posttest. Approximately 1 year later, high parental monitoring at baseline predicted significantly less use of alcohol, cocaine, prescription drugs, uppers, and ecstasy and drinking to intoxication. Study results suggest that parental monitoring serves as a protective factor, even for high-risk alternative high school students. Including a parental monitoring component may increase the effectiveness of traditional drug prevention programs.

Pneumocystis jirovecii : ce nom, que signifie-t-il ?

Pneumocystis was discovered nearly a century ago. It causes fatal pneumonia in immunocompromised individuals, especially in AIDS patients. Knowledge of the different species remained rudimentary until the mid-eighties when DNA analysis revealed its extensive diversity. In fact, it is no longer considered as a zoonosis. Pneumocystis organisms derived from different hosts have very different DNA sequences, indicating multiple species. Due to the genetic and functional disparities, the organism that causes human PCP is now named Pneumocystis jirovecii/Frenkel, 1999. We continue to call Pneumocystis carinii the species found in rats. This will allow for a single international language and avoid confusion. Changing the organism's name does not preclude the use of the well-known acronym PCP because it can also be read "PneumoCystis Pneumonia." The DNA sequences and genotypage have shown that variations exist among samples of P. jiroveci. Molecular biology is helpful in the study of the mechanisms of transmission, which can only occur in the same host and the different resistances as well as providing a better understanding of the relationship between host and pathogen. P. jirovecii pneumonia in immunosuppressed patients was previously thought to result from the reactivation of a latent infection acquired in early childhood. However, today, it is believed to result from a new infection from an exogenous source.

Minimizing movement

We give approximation algorithms and inapproximability results for a class of movement problems. In general, these problems involve planning the coordinated motion of a large collection of objects (representing anything from a robot swarm or firefighter team to map labels or network messages) to achieve a global property of the network while minimizing the maximum or average movement. In particular, we consider the goals of achieving connectivity (undirected and directed), achieving connectivity between a given pair of vertices, achieving independence (a dispersion problem), and achieving a perfect matching (with applications to multicasting). This general family of movement problems encompasses an intriguing range of graph and geometric algorithms, with several real-world applications and a surprising range of approximability. In some cases, we obtain tight approximation and inapproximability results using direct techniques (without use of PCP), assuming just that P ≠ NP.

The Infant Development, Environment, and Lifestyle Study: Effects of Prenatal Methamphetamine Exposure, Polydrug Exposure, and Poverty on Intrauterine Growth

Methamphetamine use among pregnant women is an increasing problem in the United States. Effects of methamphetamine use during pregnancy on fetal growth have not been reported in large, prospective studies. We examined the neonatal growth effects of prenatal methamphetamine exposure in the multicenter, longitudinal Infant Development, Environment and Lifestyle study. The Infant Development, Environment and Lifestyle study screened 13808 subjects at 4 clinical centers: 1618 were eligible and consented, among which 84 were methamphetamine exposed, and 1534 were unexposed. Those who were methamphetamine exposed were identified by self-report and/or gas chromatography-mass spectrometry confirmation of amphetamine and metabolites in infant meconium. Those who were unexposed denied amphetamine use and had a negative meconium screen. Both groups included prenatal alcohol, tobacco, or marijuana use, but excluded use of opiates, LSD, PCP or cocaine only. Neonatal parameters included birth weight and gestational age in weeks. One-way analysis of variance and linear-regression analyses were conducted on birth weight by exposure. The relationship of methamphetamine exposure and the incidence of small for gestational age was analyzed using multivariate logistic-regression analyses. The methamphetamine exposed group was 3.5 times more likely to be small for gestational age than the unexposed group. Mothers who used tobacco during pregnancy were nearly 2 times more likely to have small-for-gestational-age infants. In addition, less maternal weight gain during pregnancy was more likely to result in a small-for-gestational-age infant. Birthweight in the methamphetamine exposed group was lower than the unexposed group. These findings suggest that prenatal methamphetamine use is associated with fetal growth restriction after adjusting for covariates. Continued follow-up will determine if these infants are at increased risk for growth abnormalities in the future.

Period and Birth-Cohort Effects on Age of First Phencyclidine (PCP) Use Among Drug Users in New York City, 1960 to 2000

The aim of the study is to determine period and birth-cohort effects in the early initiation of phencyclidine (PCP) use in drug users in New York City (NYC). We analyzed data collected from two surveys of street-recruited drug users in NYC. We used survival analysis and proportional hazards modeling to assess period and birth-cohort effects on risk for early initiation of PCP use. Of 787 participants, 292 (37.1%) had used PCP by the age of 23 years. Before 1987, there was a greater risk for initiation of PCP use through the age of 23 years (hazard ratio [HR] = 34.77; 95% confidence interval [CI], 21.45-56.36). Proportional hazards modeling showed that those born in the 1971 to 1975 birth cohort compared with those born in 1976 to 1980 had a lower risk for initiation of PCP use through age 23 years (HR = 0.58; 95% CI, 0.37-0.91). Other significant predictors of PCP use by age 23 included white race and having been in a juvenile detention center. There are period and birth-cohort differences in the likelihood of early initiation of PCP use. Changes in drug culture and social norms may influence the likelihood of initiation of PCP use. This may have implications for interventions aimed at slowing the nationwide increase in use of PCP.

Identifying the Perceived and Diagnosed Prevalence of Ecstasy Dependence Among Club Rave Attendees

ABSTRACTThe “rave” phenomenon has been a major element in the resurgence of psychedelic drug use in Western society. Purportedly central to raves is the use of “club drugs,” such as 3,4-methylenedioxymethamphetamine (MDMA or “ecstasy”). To date, however, no studies have attempted to estimate MDMA dependence among rave attendees. In the current study, personal drug data were collected from 154 adult “club rave” attendees along the Baltimore-Washington corridor between September and November 2002. The Center for Substance Abuse Research (CESAR) Arrestee Drug Screener (CADS) was used to screen for ecstasy dependence. Seventeen percent of the sample was diagnosed with probable MDMA-dcpendencc. MDMA-dependent rave attendees were significantly more likely than non-dependents to be male, white, and to have used most illicit drugs during the 12 months preceding the interview. Logistic regression identified that gender, race, and past-year use of marijuana and PCP were the strongest predictors of MDMA dependence. Implications for these findings are discussed. /Article copies available for a fee from The Haworth Document Delivery Service: 1- 800-HA WORTH. E-mail address: <docdelivery@haworthpress.com> Website: <http://www.HaworthPress.com> © 2004 by The Haworth Press. Inc. All rights reserved.]

Teens Reduce Use Of Most Illicit Drugs

Teens Reduce Use Of Most Illicit Drugs

Historical trends of PCDD/Fs and CO-PCBs in a sediment core collected in Sendai Bay, Japan

The vertical distribution of dioxins in a sediment core was investigated to elucidate historical trends of dioxins discharged into Sendai Bay, Japan. The dioxin concentration was 410pg/g dry weight (dw) in sediments deposited in the mid-1930s and 3870pg/g dw in those deposited in the mid-1980s. Dioxin fluxes increased from the mid-1930s and then reached a maximum in the mid-1980s. 1,3,6,8-TeCDD+1,3,7,9-TeCDD, OCDD, and Co-PCB concentrations were 110, 140, and 26pg/g dw, respectively, in mid-1930s sediments, and reached maximums of 1800, 1100, and 200pg/g dw, respectively, in mid-1980s sediments. Shipments to Miyagi Prefecture of CNP and PCP products, the major sources of 1,3,6,8-TeCDD+1,3,7,9-TeCDD and OCDD, were highest in 1975 (4700t) and 1970 (3100t), respectively; and in Japan, the amount of PCBs, the major source of Co-PCB congeners, used was highest (11,100t) in 1970. Thus, the period for which the maximum concentrations of 1,3,6,8+1,3,7,9-TeCDD, OCDD, and Co-PCBs were measured in the sediment core (mid-1980s) did not correspond to the time of maximum use of CNP, PCP, or PCB products, but lagged behind by more than 10 years. We attributed this time lag to the time required for the movement of dioxins from Miyagi Prefecture to Sendai Bay.

Exemption from Harmonization Measures under Article 100a(4): The Second Authorization of the German Ban on PCP

This article assesses the legality of the Commission's second Decision authorizing Germany to maintain its PCP ban on the basis of Article 100a(4) of the EEC Treaty. After reviewing the content of Directive 911173 on the restrictions on marketing and use of PCP and Germany's more restrictive regime, this article focuses on the compliance of the Commission's Decision with Articles 190 and 100a(4) of the Treaty. Specifically, it examines the conditions under which the Commission may authorize a Member State to derogate from a harmonization measure. It contends that since Germany failed to demonstrate that its regulation banning PCP meets the necessity and proportionality tests under Article 100a(4), the Commission erred in granting an exemption from Directive 911173. Finally, this article provides a brief overview of the pending review process under the PCP Directive.

Recovery of neuropsychological functions during reduction in use of phencyclidine

A battery of 12 neuropsychological tests were administered on two occasions to 15 chronic PCP users who reduced or eliminated use of PCP over a 4-week period. A comparison sample of 15 non-PCP drug users who did not differ in age, sex, education, and ethnic composition also were tested at the two time periods. Impairment, initially higher for PCP users, decreased significantly after reduction in use of PCP. A nonsignificant increase in impairment was found for non-PCP drug users. Analysis of each variable revealed that substantial improvement occurred on the acquisition, recall, and delayed recall scores of the Randt Memory Test. Improvement also was noted for some individuals on Trails B and Digit Symbol tests.