In this paper we present basic observations regarding the formation and effect of various polyatomic metallic interferences (combinations of Pb, Al, Si, Mo, W, Fe, Sn, Ti, Ba, and Pt) on uranium isotopic ratios measured via a new Multi Collector – Inductively Coupled Plasma – Mass Spectrometer (MC-ICP-MS) platform: The ThermoFisher Scientific™ Neoma® (without the MS/MS® collision cell option). Our approach is to dope a uranium isotopic standard (IRMM-2020) with various quantities of the metallic elements, all of which have been previously identified as posing isobaric interferences during uranium isotope measurement, and then perform analyses in solution mode and by laser ablation (LA) MC-ICP-MS. As expected, there is considerable variability between the different elementally doped solution and the degree of perturbation exhibited by the uranium isotope standard. However, Pt appears to induce the most drastic shift for 234U/238U, 235U/238U, and 236U/238U. One unexpected result is that the presence of Pb, whether alone or in combination with Al and Si, appears to result in a reduction of the expected uranium signal. This effect was observed (and re-confirmed using a different cup configuration) on the Neoma® MC-ICP-MS during wet plasma analysis, but was not observed during dry plasma conditions (e.g. laser ablation sampling of dried IRMM-2020 containing Pb). Furthermore, the phenomenon was also not observed during dry plasma analysis on a NeptunePlus®. Further experiments will be necessary to fully understand the origin of this signal attenuation, and the results of our study highlight the need for continued investigation of the polyatomic interference issue as new MC-ICP-MS platforms are developed since our results clearly demonstrate that they can drastically skew the observed isotope ratios in sometimes unexpected directions. Lastly, the use of N2 during LA sampling appears to slightly increase the magnitude of the interferences compared to when only Ar is utilized as the carrier gas. This observation further highlights the importance of plasma conditions on interference formation.