Use Of Mineral Water Research Articles

The Role of Water in the Life of Living Organisms

The article discusses the biological, physical, and chemical properties of natural drinking and bottled mineral waters and examines their mechanism of effect on human health. It provides information on the criteria that drinking water must meet to be considered safe and offers a comparative analysis of mineral waters. The use of various types of mineral waters in the treatment of specific diseases is investigated. The physical and chemical indicators of mineral waters produced in the Nakhchivan Autonomous Republic and their benefits are described. The research concludes that while proper and effective use of mineral waters is beneficial to human health, improper use without considering their composition can lead to serious safety issues.

HYDROGEOLOGICAL CHARACTERIZATION AND GENESIS OF MINERAL WATER "TESANJSKI KISELJAK"

Ensuring the exploitation and use of mineral water "Tešanjski kiseljak" implies the analysis and performance of complex geological, hydrogeological, hydrological, quantitative, qualitative and genetic research, as well as the definition and establishment of high ecological standards in the researched area of the "Tešanjski kiseljak" source, along with exemplary field and laboratory and cabinet analyzes and data processing. The basic criteria for defining the genesis and regime, hydrogeological relations and protection of mineral waters are geological and geomorphological characteristics of the terrain, climatic and hydrographic conditions, structural- tectonic and hydrogeological characteristics of the terrain, quantitative and qualitative characteristics of the source, existing and potential pollutants of the source, analysis of genetic and hydrodynamic aquifer parameters from which protection zones and source protection measures arise Depending on the hydrogeological characteristics of the terrain, the relationship between permeable and impermeable rocks, the position of the aquifer in relation to atmospheric and surface waters, recharge conditions, permeability and hydrogeological parameters, the existence of the water body of mineral waters, the renewal of its reserves and the quality of mineral waters depends. Key words: mineral waters, hydrogeological categorization, structural-tectonic relations, water genesis

Сurrent state and prospects of the Sakhalin balneological potential in rehabilitation and health resort treatment

Aim. To assess the prospects for the use of mineral waters and therapeutic muds (peloids) of the Sakhalin region for treatment and prophylactic purposes on the basis of their balneological properties.Materials and methods. The results of balneological analyses of mineral waters and therapeutic muds of the island areas of the Sakhalin region and regulatory documents were used.Results. The mineral waters and therapeutic muds of the Sakhalin region as its major therapeutic resources are characterized. The main groups of mineral waters for internal and external use include siliceous thermal, iodobromic, arsenic, and boric waters. It is noted that unique deposits of Sakhalin-type mineral waters, such as acidic waters with a high content of metals, petroleum products, and organic substances, require additional research. The Sakhalin region is rich in all available types of therapeutic muds– silt sulfide, mound, peat, and sapropel.Conclusion. The Sakhalin region possesses a wide variety of balneological resources for health resort treatment and rehabilitation. Among them are the deposits of mineral waters and therapeutic muds that are promising for research and use in medical and wellness organizations.

Problems of providing the Leningrad region`s population with full-fledged drinking water from underground sources

Introduction. There are about 2,900 settlements in the Leningrad Region, the centralized water supply of most of which is based on the underground aquifers’ exploitation, which water is a significant source of essential elements. 
 Material and methods. The paper analyzes the results of 143,578 drinking water samples from 10 aquifers used as sources of drinking water supply. Within the framework of this study, the content of the following elements was evaluated: calcium, magnesium, potassium, copper, zinc, phosphorus, iron, manganese, selenium, molybdenum, chromium, sodium, chlorides, fluorides in comparison with the methodological recommendations of MP 2.3.1.0253–21 “Norms of physiological energy and nutritional needs for various population groups of the Russian Federation”. 
 Results. None of the aquifers of the Leningrad region provide the concentrations of phosphates, copper, potassium, zinc and selenium did not satisfy 20% of the minimum required intake from drinking water. Insufficient intake of essential macro- and microelements with drinking water can become one of the causes of metabolic disorders and lead to health disorders. 
 Limitations. Within the framework of this article, water quality is characterized by sanitary and chemical indicators, the chemical harmlessness of water is evaluated. The issues of microbiological and radiological safety of underground water in the Leningrad region, despite their relevance, aren`t considered in this article. In addition, the quality of drinking water in Sosnovy Bor wasn`t studied, since the centralized water supply of this locality is carried out from surface water sources.
 Conclusion. Despite the undoubted advantages of groundwater, they are not able to satisfy the physiological need of the body for macro- and microelements. In this regard, it is necessary to develop targeted preventive programs aimed at replenishing the deficiency of micro- and macroelements in the body for each territory of the Leningrad region. These include the consumption of foods rich in microelements, the intake of biologically active additives containing scarce micro- and macroelements, as well as the use of mineral waters.

Ресурсная база лечебных минеральных вод Республики Коми

The Komi Republic, occupying a vast (416.8 thousand km2) territory in the European northeast with a small (less than 800 thousand people) population, belongs to the regions with poor development of the sanatorium-resort complex, though with a large potential. In the republic, the role of mineral waters as a natural healing factor is not sufficiently appreciated and the use is limited. Natural medicinal resources of the Komi Republic — different in composition and properties, according to the main balneological indicators, underground mineral waters that can have a strong physiological effect on the human body are represented by groups: bromine, iodine-bromine, boron, hydrogen sulfide, ferruginous and with a high content of organic matter, with a maximum the distribution of waters “without specific components and properties.” The general characteristics of exploited mineral water deposits are given. Highly mineralized waters and brines from three deposits are used for balneotherapy, industrial bottling is carried out at two deposits of medicinal mineral drinking waters. The degree of development of explored mineral reserves is only 1% of the total. The average value of mineral water bottled in the republic is only 5 l/year per person. On the territory of the Komi Republic in the Arctic zone there are two deposits of drinking mineral waters: Yaneytyvisskoe in the area of the city of Vorkuta and Komanyurskoe in the city of Usinsk, which are not used. On their basis, it is possible to create enterprises for the production of bottled therapeutic mineral waters. Mineral underground water deposits have not been explored within the Nenets Autonomous Area, while the Pymva-Shor thermal springs are especially promising in using for balneological purposes. The author has substantiated the wider use of mineral waters for resort and economic development of the territory.

The effect of mineral water on the course of experimental oxalate nephrolithiasis

Introduction. The number of patients with urolithiasis (UCD) is increasing annually both among the adult population and among children, and therefore it is necessary to develop an integrated approach to the prevention and treatment of this pathology. Most often, with urolithiasis, oxalate-calcium crystalluria is determined, to reduce the level of which, low-mineralized mineral waters with a minimum sodium content are recommended.Aim. To study the effect of mineral water “Serebryanyy klyuch” on the course of experimental calcium oxalate nephrolithiasis.Materials and methods. During the study on laboratory rats, oxalate nephrolithiasis was simulated for 3 weeks by providing a 1% solution of ethylene glycol as a drink, while the rats of the experimental group used mineral water “Serebryanyy klyuch” as a solvent. The results of urine biochemistry (calcium, creatinine, activity of lactate dehydrogenase and γ-glutamyl transferase) and morphological studies (determination of the amount and size of calcium deposits in the kidneys, assessment of the structural and functional state of the nephrothelium) were evaluated.Results. Calcium-oxalate deposits in the control group of rats were detected in 25% of cases, while large-sized stones were observed in the kidney tubules. In the experimental group, the presence of stone deposits was detected in 1 (11.1%) case, with a clear shift towards smaller deposits. Morphological signs indicating the development of dystrophic changes with the phenomena of nephrosclerosis were much less pronounced in the conditions of consumption of mineral water “Serebryanyy klyuch”.Conclusion. Thus, the use of mineral water “Serebryanyy klyuch” in the conditions of a three-week experimental oxalate nephrolithiasis was accompanied by characteristic signs of facilitating the course of the pathology and contributed to a decrease in the proportion of large calculi in the kidneys.

Effect of Balneotherapy on Skin Lesion at Hot Springs in Southern Ethiopia: A Single-Arm Prospective Cohort Study.

Balneotherapy is the use of mineral water for the treatment of a wide range of diseases including skin lesions. Even though Ethiopia has a large number of places with natural hot springs, their therapeutic value has not been thoroughly studied. The aim of this study was to determine the effect of balneotherapy among patients with skin lesions at hot springs in southern Ethiopia. A single-arm prospective cohort study design was used to assess patient's progress from their skin lesion complaint after using the hot water for at least three consecutive days or more. An individual visiting the hot springs site and staying there for at least three days or more was included in the study. From four hot springs sites in Southern Ethiopia, 1320 study participants who were 18 years of age or older were enrolled. The data were gathered using a standardized questionnaire and a physical examination. A descriptive analysis was made. Of the total, 142 (10.8%) of them had various skin lesions. Flexural lesions accounted 87 (61.3%), non-specific skin conditions 51 (35.9%), co-lesions at the scalp, external ear canal, trunk, and various locations, and psoriatic lesions comprised 4.8%. There were 72 (82.8%) typical eczematous lesions among the total number of flexural lesions. After using balneotherapy for 3-7 days once daily, 69 (95.2%) cases of eczematous dermatitis and 30 (58.8%) cases of non-specific skin issues showed improvement from the lesion. Additionally, after 30 days of bathing once daily, the PASI score of more than 90% of the psoriatic cases dropped to a score of one. Patients with skin lesions benefit significantly from balneotherapy when it lasts for three or more days. In order to improve skin lesions, proper application for at least a week or longer is highly beneficial.

ФОРМУВАННЯ ТУРИСТИЧНОЇ ДЕСТИНАЦІЇ САНАТОРНО- КУРОРТНОГО ТИПУ НА ОСНОВІ ДЖЕРЕЛА МІНЕРАЛЬНОЇ ВОДИ «БУКОВИНСЬКА»

Increasing demand of the population in a healthy way of lifestyle and in an active recreation in combination with recreational and health-improving procedures actualize the problem of theoretical grounding and legislative security for the formation of tourist destinations of the sanatorium-resort type, determining the advantages of the territory for creating a destination and its impact on the socio-economic development of the community or region. The provision of resource supply for the formation of a recreational and health- improving destination of a sanatorium-resort type and the use of mineral water «Bukovynska» both for satisfaction of basic needs, and in recreational purposes, are an urgent problem requiring a solution. The purpose of the research is to determine the regulatory and legal support and the main criteria for the formation of the sanatorium-resort type tourist destination, to establish the tourist and recreational advantages of the territory of the village of Budenets for the creation of a destination in the Chudei Rural United Territorial Community based on the spring of mineral water «Bukovynska» and to determine its impact on socio-economic development of the community. The legislation of Ukraine, the works of domestic and foreign scientists, methods of analysis and theoretical generalization to determine the legal support of the processes of forming a tourist destination, analysis and synthesis to establish the tourist and recreational advantages of the territorial community served as the theoretical and methodological basis for writing the article. Based on the analysis of the legislation of Ukraine, it was established that a legal field has been created for the formation of tourist destinations of the sanatorium-resort type, which ECO N O MI CS AN D M ANA G EM EN T H OSP I TAL I TY ENTERPRISES Issue I (89), 2023 79 ensures the effective use of the natural and recreational potential of certain territories. The article focuses on the development of general and special infrastructure, in particular, the presence of treatment and rehabilitation facilities, accommodation and catering enterprises, which must meet approved standards and other regulatory documents. The analysis of the capabilities of the Chudei rural united territorial community contributed to the identification of advantages for the formation of a tourist destination of the sanatorium-resort type in the village of Budenets based on a source of mineral water «Bukovynska». The article highlights the main components of the economic impact that arise during the formation and functioning of a tourist destination in the territorial space of the community. The Chudei Territorial Community has been identified as a basic area for the formation and development of a sanatorium-resort-type tourist destination, which will contribute to the effective use of local potential, the development of entrepreneurship and the provision of income to the community budget, the attraction of investment resources, the development of general infrastructure and the overall economic development of the community.

Features of the use of mineral waters for therapeutic and prophylactic purposes

Mineral waters make it possible not only to influence significantly the processes of normal life, replenishing the body with the necessary microelements and biologically active substances that are produced by certain microbes living in water, and to maintain the necessary acid-base balance and water balance in the body, but, most importantly, they allow successfully treating many diseases and increasing the body»s defenses. Mineral waters contain more than 50 different chemical elements in the form of salts: bicarbonates, sulfate chlorides, metals, and microelements (potassium, sodium, calcium, magnesium, iron, copper, zinc, molybdenum, cobalt, fluorine, iodine, bromine).

Criminal law regulation of traditional medicine methods of healing according to the legislation of Russia

It is worth noting that in modern society, traditional medicine methods are still used. In this regard, a detailed definition of the criminal-legal limits of the practical implementation of healing methods within the framework of traditional medicine should be determined not only at the level of medical rules, but also in the relevant, in our case, criminal legislation. The article describes the practical methods of healing in the framework of traditional medicine, such as herbalism, the use of mineral waters and therapeutic mud, bloodletting, folk hygiene, etc. It is also noted that healing based on folk medicine methods can be socially harmful. Accordingly, the criminal legal limits of the implementation of appropriate medical manipulations on the basis of Russian criminal legislation are considered here.

Advanced utilization of multi-learning algorithm: ensemble super learner to map groundwater potential for potable mineral water

Although mapping the groundwater quality is crucial for people who require groundwater with strict quality standards, the ability to take intensive measurements has been restricted by a lack of groundwater accessibility. Thus, this study aimed to estimate and map the suitability of groundwater quality for use as potable mineral water. We attempted a novel approach by targeting comprehensive qualities for a specific groundwater use and by adopting a super learner that combines multiple different learning algorithms. The super learner generated a groundwater potential map indicating a zone with a high potential for mineral water and it outperformed the base learners by 21%–74%. Estimation results designated appropriate groundwater development locations for mineral water use, and assessment of predictors determined favorable environments. Consequently, the proposed approach presented a possible method for finding groundwater with the required quality for its optimal usage. Furthermore, it provided the possibility of worldwide application.

Study of the effectiveness of the use of mineral water with a high content of biologically active components in experimental dermatosis

Introduction. The widespread occurrence of atopic dermatitis and the presence of complications in the use of medical drugs in the existing protocols for its treatment requires the study of pathogenetically determined non-medical therapies. The addition of balneotherapy methods to the treatment complex can increase the effectiveness of treatment and reduce the manifestations or consequences of complications of the drug load. Purpose. The presence of corrective effect of natural mineral water (NMW) with high content of hydrogen sulfide and boron was evaluated in white rats with reproduced model of dermatosis. Morphological, immunological and statistical methods were used in the work. The model of dermatosis was reproduced by sequential applications of xylene and paraformaldehyde on the shaved skin of the rat. The treatment course included 6 procedures (applications were performed every other day, the duration of each application was 20 minutes). Results. After a course of applications with MW, microscopic examination revealed the removal of inflammation in the skin and activation of epidermal regeneration. The analysis of hematological parameters revealed the recovery of the percentage of lymphocytes, acidophils, neutrophils and monocytes, phagocytosis processes and normalization of the cellular and humoral components of the immune system. Positive changes in other investigated metabolic systems were also determined. The activity of the processes of energy-dependent transmembrane transport was restored, the balance in the system of lipid peroxidation and antioxidant protection was normalized, the content of seromucoids was reduced and the content of total protein and protein spectrum of blood was normalized. Conclusions. Thus, the limitation of the development of the pathological process and the reduction of the level of allergization of the organism were determined, which indicates the presence of a significant corrective effect of the MW used in the study, and its high biological activity.

Hyperenzymemia after vaccination against COVID-19: complex equation with simple variables

The article presents clinical case of the jaundice development and severe hyperenzymemia in GAM-Covid-VAK (Sputnik V) vaccination against COVID-19 in a 69-year-old patient. History — systematic use of non-steroidal anti-inflammatory drugs due to persisting pain after knee arthroplasty in 2018; frequent trips for several years to another region for sanatorium treatment, the use of mineral water. The diseases caused by hepatitis viruses, drug damage and post-vaccination reaction were included in diagnostic search. The markers of hepatitis B and C infection viruses were not detected during the enzyme immunoassay and polymerase chain reaction. The indicator for determining the relationship of a drug with the liver damage development was 6 points (borderline value) and only indicated the likelihood of drug hepatotoxicity. At the same time, it is known from history that repeated administration of the drug did not cause liver dysfunctions. The diagnosis of coronavirus infection was established based on the identification of SARS-CoV-2 in the hospital with repeated laboratory testing and competing diagnosis of hepatitis A has been confirmed on the basis of hepatocellular damage and the presence of serological marker of hepatitis A virus (immunoglobulin M antibodies). The treatment was continued in the infectious hospital, where the diagnosis of co-infection was confirmed. The pneumofibrotic changes in the S5 region of the left lung were revealed according to computed tomography. The normalization of aminotransferase activity and bilirubin was noted during dynamic observation. Apparently HAV infection led to a decrease in the immune response, the formation of an insufficient level of neutralizing antibodies in vaccinated against COVID-19 patient M. and contributed to the development of a new coronavirus infection with minimal manifestations in contact with SARS-CoV-2.

Therapeutic physical factors in restorative treatment of patients with nonalcoholic steatohepatitis combined with biliary sludge

Purpose of the study. To study the effectiveness of restorative treatment of patients with nonalcoholic steatohepatitis in combination with biliary sludge at the inpatient stage when low-mineralized mineral water and preformed peloid therapy are included in the basic scheme. Material and methods. A total of 119 patients with nonalcoholic steatohepatitis in combination with biliary sludge were observed and distributed into 3 randomized groups: in the main group, 39 patients received basic drug therapy in accordance with the Federal Clinical Recommendations, «Sernovodskaya» mineral water for ingestion and in the form of gallbladder cleanse, and preformed application peloid therapy; in the comparison group, 40people received only pharmacotherapy and balneotherapy, in the control group — pharmacotherapy. The control of the effectiveness of the treatment was carried out according to the dynamics of clinical, biochemical and functional studies. Results. The inclusion of medium-mineralized mineral water «Sernovodskaya» in the form of drinking treatment and cleanse and preformed peloid therapy in the complex of therapeutic measures for patients provides a significant decrease in the intensity of clinical manifestations by 54.4% versus 40% with the use of pharmaco- and balneotherapy and 28,8% — with only drug therapy; cytolysis and cholestasis syndromes — by 46,2; 39,8 and 28.9%, respectively. Restoration of the contractile function of the gallbladder is observed in 78,8% of cases versus 65.6% when using only pharmacotherapy. The duration of hospitalization in the main group was reduced by 3 days, and in the comparison group — by 1,5 days, compared with the indicators in the control group. Conclusion. The developed new medical technology for the treatment of patients with nonalcoholic steatohepatitis in combination with biliary sludge with the combined use of mineral waters and preformed peloid preparations against the background of basic pharmacotherapy at the inpatient stage provides a significant increase in the efficiency of therapeutic measures.

Research on the exploitation and utilization degree of mineral water based on ecological base flow in the Changbai Mountain basalt area, northeast China.

Mineral water from the Changbai Mountain basalt area is China's most important source of drinking water. Mineral water with abundant output and enriched trace elements has driven the rapid development of the local economy. However, the extensive exploitation of mineral water and the neglect of ecological base flows threaten interdependent river ecosystems. In order to ensure the sustainable use of mineral water, it's necessary to calculate the exploitation and utilization of mineral water according to the ecological base flow. In this study, four hydrological methods were used to analyze the intra-annual and inter-annual ecological base flows, namely the Tennant method, the base flow ratio method, the driest monthly average flow method and the Texas method. The results show that the ecological base flow during the flood season is about 3-4 times that during the non-flood season. Affected by rainfall and runoff, the inter-annual ecological base flow also fluctuated within a small range. This study divides the mineral water exploitation coefficient into five categories and proposes an assessment of the mineral water exploitation potential based on the ecological base flow. It shows that the flow of Baijiang River spring group is the largest, but it's exploitation potential is normal. Huangni River spring group at weak level for exploitation because of its small flow rate. It's obvious that river runoff is not the only factor that determines the exploitation coefficient of the spring group. The proportion of ecological base flow and the proportion of river base flow are also important factors.

Mineral Waters of the Eastern Ukraine

This article considers the distribution, formation, and chemical composition of mineral waters of the Eastern region of Ukraine, and, in particular, Donetsk, Luhansk, and Kharkiv regions. The main types of mineral waters, most characteristic of the Eastern region of Ukraine, are determined. Their formation and distribution are considered. Manifestations of ferrous, bromine, boron and iodine waters have been studied in this region, which significantly expands hydromineral and balneological resources. The application of ferrous mineral waters to organisms exposed to radiation has been studied. Since one of the consequences of radiation damage is a violation of oxidative homeostasis, the effect of ferrous mineral waters on the course of free radical processes in the body was studied. The peculiarities of the organic composition and biological properties of Berezivsky mineral waters have been studied to identify them as Naftusya-type waters. It is established that Berezivsky mineral waters do not have a pronounced radiomodifier effect. They are inhibitors of the enzymatic activity of catalase — a key regulator of oxidative metabolism, which leads to a deterioration in the vital functions of the body after irradiation. According to the obtained data of mass spectra, active organic substances of different classes, which are part of mineral waters of the Naftusya type, differ from organic substances of Berezivsky mineral waters, both qualitatively and quantitatively. Therefore, Berezivsky mineral waters cannot be referred to as the class of mineral waters of the Naftusya type. Some studies were also conducted and an array of statistics was obtained, which showed that the mineral waters of the Podilsk region, Naftusya and Berezivsky waters have pesticide concentrations less than 0.01 ng/dm3, i.e. 10 000 times lower than their permissible concentrations according to international standards. This confirms the possibility of widespread use and export of Ukrainian mineral waters, which is of national importance. Prospects for the development and use of mineral waters in the Eastern region are shown.

The potential of using the underground mineral waters of the Moscow region in the organization of medical rehabilitation and medical tourism

Moscow in modern borders is the largest metropolitan area in the country with a fairly high and unevenly distributed population density. This predetermines the need to address environmental regulation of urbanization in order to create the most comfortable living conditions for the population. Health care and the maintenance of health of all age groups are the leading role in the list of the most important tasks to ensure the social well-being of citizens. In the bowels of the Moscow region there are natural therapeutic resources: low-mineralized (M 3-5 g/l) sulfate sodium-magnesium-calcium drinking mineral water and chloride sodium bromine brine. The article presents the characteristics of the natural therapeutic resources of the Moscow region, the area of their therapeutic use, justified the possibility of wider use based on the available scientific data on the effect on the body of these waters and their analogues. All this provides an opportunity to achieve the main goal of medical resortology - the use of mineral water as a means of therapy, rehabilitation and prevention of most existing human diseases.

Drinking mineral waters: problematic issues and prospects of use in treatment and rehabilitation

The article is devoted to the use of drinking mineral waters in the treatment and rehabilitation of patients with various pathologies. The results of numerous studies carried out in previous years have proven the ability of mineral waters to positively influence the functional state of the digestive system, eliminate various metabolic disorders, and affect the processes of hormonal and immune regulation. However, due to the current lack of educational programs for the training of doctors at medical universities, as well as further training in the basics of balneology, medical workers often encounter difficulties in determining the most suitable schemes for the use of mineral waters for a specific pathology. It is known that today there are quite a lot of bottled waters on the market that do not have a healing effect, but are quite suitable for use as table waters. The latter circumstance, combined with not always correct information about the real healing properties of waters, creates certain difficulties even for doctors. In addition, there is a need for a certain clarification of the methods of prescribing mineral waters, taking into account the magnitude of mineralization, the main cation-anionic composition, the nature of the disease and the phase of its course. Taking into account the fact that drinking mineral waters are actively used in the treatment of many diseases, including in children and the elderly, the task of fully and competently informing doctors of different specialties, and with their help, patients, about the features of specific mineral waters available in different regions of the Russian Federation, their unique capabilities, optimal methods of therapeutic use.

РАЗРАБОТКА НАПРАВЛЕНИЙ РАЗВИТИЯ УСЛУГ РЕГИОНА НА ОСНОВЕ ИСПОЛЬЗОВАНИЯ ПОТЕНЦИАЛЬНЫХ ПРИРОДНЫХ ЛЕЧЕБНЫХ РЕСУРСОВ

The article is devoted to the situational analysis of the directions of services development in the region and increasing the commercial effect of their use, taking into account the unique physical and chemical characteristics of natural healing resources. In the current economic conditions, optimizing the use of resource potential is significant and allows you to implement several strategic goals. The mass use of mineral waters in the system of tourist and recreational organizations allows you to diversify the offer of the sanatorium and resort complex, contribute to the saturation of the market of medical and recreational services and stimulate demand. The purpose of the study is to determine the directions of development of services in the region based on the use of potential natural healing resources that have value properties for the psychophysiological recovery of a person. Research objectives: 1) characteristics of natural healing resources of the Perm Territory; 2) description of the physical and chemical characteristics of mineral waters and their impact on the development of the medical profile of resort medicine enterprises; 3) development of directions for the development of services in the region, taking into account the value characteristics of the resource potential. The research methods are analytical, systematic and modeling of economic processes. The study has revealed the high importance of some territories of the Perm Region for the development of the sphere of medical and health services. Improving the commercial efficiency of mineral water use should be developed taking into account the directions of the impact on human health, stable domestic demand and the infrastructure of resort areas. Trends in a healthy lifestyle have a positive impact on the development of the market of services related to wellness, cosmetology, and rational nutrition. The proposed directions for the development of the service sector are based on the unique properties of the mineral waters of the therapeutic areas of the Perm Region, and are related to the expectations of consumers

Balneogynaecology in the 21st century: increasingly recommended primary and complementary treatment of chronic gynaecological diseases.

Balneo-gynaecological treatment methods include external bath hydrotherapy, sedentary baths and topical dressings/cataplasm, and internal (intravaginal or intrarectal use of peloids and mineral water). Hyperosmolar thermal spas have been very popular in the treatment of infertility due to the improvement of symptoms of chronic pelvic pain, endometriosis, chronic vascular and inflammatory pelvic diseases. Acute pelvic inflammatory syndrome is a contraindication for balneo-hydrotherapy while hyperthermal hydrotherapy is contraindicated in endometriosis and neurovegetative dystonia due to the stimulation of hyperemia, which worsens the clinical picture. Balneo-hydrotherapy is not recommended in metrorrhagia and malignancies. Balneogynaecological treatment certainly has its own primary but also complementary role in the treatment of chronic gynaecological diseases and is increasingly recommended today.