The effect of mineral water on the course of experimental oxalate nephrolithiasis

Abstract

Introduction. The number of patients with urolithiasis (UCD) is increasing annually both among the adult population and among children, and therefore it is necessary to develop an integrated approach to the prevention and treatment of this pathology. Most often, with urolithiasis, oxalate-calcium crystalluria is determined, to reduce the level of which, low-mineralized mineral waters with a minimum sodium content are recommended.Aim. To study the effect of mineral water “Serebryanyy klyuch” on the course of experimental calcium oxalate nephrolithiasis.Materials and methods. During the study on laboratory rats, oxalate nephrolithiasis was simulated for 3 weeks by providing a 1% solution of ethylene glycol as a drink, while the rats of the experimental group used mineral water “Serebryanyy klyuch” as a solvent. The results of urine biochemistry (calcium, creatinine, activity of lactate dehydrogenase and γ-glutamyl transferase) and morphological studies (determination of the amount and size of calcium deposits in the kidneys, assessment of the structural and functional state of the nephrothelium) were evaluated.Results. Calcium-oxalate deposits in the control group of rats were detected in 25% of cases, while large-sized stones were observed in the kidney tubules. In the experimental group, the presence of stone deposits was detected in 1 (11.1%) case, with a clear shift towards smaller deposits. Morphological signs indicating the development of dystrophic changes with the phenomena of nephrosclerosis were much less pronounced in the conditions of consumption of mineral water “Serebryanyy klyuch”.Conclusion. Thus, the use of mineral water “Serebryanyy klyuch” in the conditions of a three-week experimental oxalate nephrolithiasis was accompanied by characteristic signs of facilitating the course of the pathology and contributed to a decrease in the proportion of large calculi in the kidneys.