The method of the research was to identify promising trends in the use of medical knowledge in pedagogical and psychological activity in the context of emotional, physical and spiritual well-being of modern society. In the research, a SWOT-analysis was carried out, which identifies the main risks, opportunities, weaknesses, and strengths of integrating medical knowledge in psycho-pedagogical practice. Medical knowledge and its application to human personality through the activity of pedagogues and psychologists. The interpretation of the concepts of “medical psychology”, “medical pedagogy”, “integration” and their peculiarities in the modern world is described. Examples of the application of medical knowledge in psycho-pedagogical practice and their application are given. It is understood that the psychological-pedagogical represents a mutually interconnected system that combines theoretical and practical components with the disclosure of the essence of medical knowledge and the development of specific situations. The main functions, possibilities, and risks of pedagogical and psychological activity in the implementation of this process on the basis of modern and innovative technologies. Theoretical experience in the development of medical knowledge in psycho-pedagogical activity of such foreign countries as the United States, Great Britain, Germany, Italy, and the East of Korea). The following advantages of its application are identified: a great improvement of motivation for learning, formation of clinical thinking, skills and competences in education teachers, excellent learning of the required material, professional skills and competences, achievement of successful results in the formation of personal qualities of the student. In accordance with this, the consequences are the creation of a basis for the development of creative individuals, their training with the assimilation of medical knowledge to professional activity in the future and the understanding of the need for quality education throughout life. The conclusions provide information about the changes in the conditions of existence of the society, which were the result of mental, emotional, informational and ecological influence. The practical significance of the work is to improve the physical and mental health of children and adults, as well as to improve their educational and career success