The current study uses a qualitative methodology to investigate socio-cultural and psychological aspects involved in the use of LSD and comparable psychedelic substances. To date, 26 narrative interviews have been conducted with 12 female and 14 male users aged 19 to 53 years. The resulting data were subjected to content analysis in several thematic areas. Subjective reports of LSD use and experiences are considered among the complex interrelationship of drug effects, individual and environmental factors, as well as in comparison to the results reported in earlier research. Preliminary results suggest the use of LSD is largely independent of the “party drugs” scene, although its users do embrace elements of alternative lifestyles and subcultures. The majority of participants report their LSD experiences to be of great importance and to have intellectual relevance for their individuation process and personality development. Exploration of the self and the desire to experience profound changes in their perception of the world are reported as primary motives for LSD use, in addition to its hedonistic value. Individual backgrounds, knowledge and patterns of reaction are found to strongly influence the character of the drug effects that are experienced. Next to a wide range of extra-pharmacological factors, various methods for actively modifying LSD induced states were discovered to determine the general character of LSD experiences. These are discussed with regard to their implications for the development of suitable harm reduction concepts.