Use Of Low-energy Laser Research Articles

Research on evolution process of full-layer incision of skin tissue under different laser incidences.

Considering difficulties of achieving vertical incidence of beam in different positions of skin, it is significant to study potential effects of incidence angles of laser on incisions. Surgical platform with a 1064 nm continuous fiber laser was established. Incident angle was adopted and real-time temperature fluctuations in laser operating area could be monitored. The rats were treated with laser at day 0 and day 3 after incision modeling, and H&E, Masson, Sirius Red, and Immuno-histochemical staining and enzyme-linked immunosorbent assay were adopted at day 3, 7, 14 to analyze the performance of healing. Laser with energy density of 67.54 J/mm2 can effectively accelerate wound healing in vivo, in which a laser with incident angle around 60° can effectively avoid scar hyperplasia. Therefore, the use of low energy laser with a small deflection angle has a good clinical application prospect in promoting wound healing.

Application of Combined Laser Irradiation in Postoperative Period in Patients with Complicated Hepatic Echinococcosis

The article presents an analysis of the results of surgical treatment of patients with complicated liver echinococcosis in 102 patients using laser technology in the postoperative period. The patients were divided into 2 groups. Group I 62 (61%) patients with the use of laser technology in the postoperative period. II group 40 (39%) patients with the traditional method. Due to the use of low-energy lasers in the postoperative period with complicated liver echinococcosis, the proportion of complications was reduced by 3-3.5 times, and the duration of inpatient treatment was reduced by 1.5-2 times

Effect of bioactive glass-based composite and low energylaser on bone regeneration in an experimentally induced bone defect

In vivo experimental study was conducted to investigate the effect of bone regeneration under the use of a bioactive glass-based composite as well as the use of laser irradiation in the presence of the bioactive glass-based composite. In 16 white non-inbred rats, with a body weight of 300–350 g the bioactive glass-based composite was implanted into the tibial metaphysis. Besides, 90 female rats of the Wistar line weighing 250–270 g underwent laser irradiation on an artificially created tibial bone defect filled with the bioactive glass-based composite. The period of observation lasted respectively 2 and 4 weeks. It was found that application of the bioactive glass promotes bone regeneration, which is noticeably enhanced with the use of low energy laser. The combining effect leads to a significant increase in bone regeneration and the expression of bone tissue metabolic markers: osteocalcin and alkaline phosphatase. The most pronounced effect of the laser on bone regeneration occurred at a wavelength of 810 nm, which opens up prospects for the use of this technique in clinical practice.

Development and evaluation of the effectiveness of photodynamic therapy in inflammatory diseases of the ocular surface

Relevance. In the treatment of inflammatory diseases of the ocular surface, in order to achieve high efficiency in the shortest possible time, it is necessary for the therapy to be comprehensive. Today, in addition to traditional treatment methods, new technologies based on the use of low-energy lasers, which have high biological activity, are spreading.
 Aim. To improve the treatment results of the inflammatory diseases of the ocular surface by implementing photodynamic therapy (PDT) in experiment and clinic, using domestic equipment and elaborating optimal energetic parameters of laser irradiation.
 Methods. Objects of research: 130 nonlinear sexually mature rats weighing 150 grams contained in standard vivarium conditions and 110 eyes of patients with inflammatory eye diseases. Carrying out the investigation, experiments on animals, clinical and functional examination results of patients, and statistical analysis were taken into consideration.
 Results. A methodology for complex treatment of inflammatory diseases of the ocular surface was developed (with inclusion of PDT by the laser therapy device Vostok), based on experimental data and confirmed by clinical and functional ocular indices. PDT helps to increase the effectiveness of treatment, which is manifested by accelerated tissue regeneration, restoration of corneal transparency, increase of visual function in 86.7%, and reduction of treatment terms to 6 days.
 Conclusions. Anti-inflammatory and regenerative effectiveness of the proposed complex treatment of inflammatory diseases of the ocular surface with the PDT use was established: improvement in the clinical picture of conjunctivitis and keratitis was revealed, manifested by increase in corneal epithelization.

The use of lasers and light sources in skin rejuvenation

Smooth, wrinkle-free skin is associated with supposed attractiveness, youthfulness, and health, while rhytids have a negative impact on one’s perceived appearance, image, and self-esteem. Noninvasive esthetic procedures such as laser or light therapy have been used to achieve and attain a more youthful appearance. Currently, there is a wide range of lasers and devices available for the regeneration and healing of skin. Lasers and light sources for skin rejuvenation involve the removal of aged skin tissue via thermal heat from high-powered lasers, stimulating the surrounding tissues to recover through natural wound-healing processes. In contrast, photobiomodulation, which makes use of low energy lasers or light emitting diodes, uses no heat and has shown positive effects in the reduction of wrinkles and improving skin laxity.

Actualités de la prévention et du traitement des mucites orales chez les enfants cancéreux : recommandations pratiques

Oral mucositis is an inflammation of the mucosa of the oral cavity of various etiologies. This is a common and debilitating complication in children treated with chemoradiotherapy for cancer. Its management remains a major concern both for the doctor than the patient. It affects the quality of life of patients and families. It may initiate the functional and vital prognosis because of the judgment of cancer treatment. Several treatment options are available, but there is no clear consensus therapeutic especially for the pediatric population. We have identified, through a comprehensive literature search indexed publications on this subject in order to review the pharmacological and non-pharmacological approaches that have been used to prevent and treat oral mucositis. Thus, current recommendations for the management of oral mucositis are very limited, and therefore the standard of care for this complication was palliative. In recent years several studies have revealed that the use of low-energy laser was particularly interesting in the prevention and treatment of radiation-induced or chemically induced mucositis. It significantly reduces the pain, the severity and duration of the ulcer by promoting wound healing. Randomized controlled trials with a large number of patients are expected to establish preventive and therapeutic protocols. Treatment with low power laser, known devoid of side effects, is a very promising oncology care to support radio-induced mucositis and chemotherapy.

From Death Rays to Light Sabers: Making Laser Weapons Surgically Precise

This paper explores how, in the two decades following the laser's invention, the popular image of the laser weapon was transformed from a terrifying "death ray" capable of contaminating large areas to a surgically precise tool and rationale for a major new defense program. Whereas previous histories of the laser treat its popularizations as irrelevant to real-world developments, this account emphasizes that mass media provide sites for scientists and engineers to vie for control over the meaning and direction of technological development. It shows how the laser as a symbol came to link two very different applications: the everyday use of low-energy lasers to increase the "precision" of technologies, and the experimental development of high-energy lasers that would be destructive. I argue that the symbolic appeal of laser weapons made the laser a central part of President Ronald Reagan's Strategic Defense Initiative or "Star Wars" missile defense program.

Efficacy of Low-Level Laser Therapy for Chronic Cutaneous Ulceration in Humans

Chronic wounds, particularly venous ulcerations, are notoriously difficult to heal. Because current therapies are variable in their ability to induce complete healing, there remains a need to develop adjunctive treatments that can improve or accelerate the healing process. The use of low-energy lasers to stimulate wound healing has been pursued over many decades in studies of varying quality. This form of treatment has had high appeal due to its novelty, relative ease, and low morbidity profile. The authors reviewed the available published literature on low-level laser technology in an attempt to provide cumulative insight on the effect of this treatment for wound healing.

The use of low-energy laser (LEL) for the prevention of chemotherapy- and/or radiotherapy-induced oral mucositis in cancer patients: results from two prospective studies

Low-energy laser (LEL) treatment has been suggested as an effective and safe method to prevent and/or treat oral mucositis induced by chemotherapy and/or radiotherapy; however, it has not gained wide acceptance so far. We conducted two clinical trials testing the LEL technique: firstly, as a secondary prevention in patients with various solid tumors treated with chemotherapy who all developed severe mucositis after a previous identical chemotherapy and, secondly, as therapeutic intervention (compared to sham illumination in a randomized way) in patients with hematological tumors receiving intensive chemotherapy and having developed low-grade oral mucositis. We entered 26 eligible patients in the first study and 36 were randomized in the second study. The success rate was 81% (95%CI = 61-93%) when LEL was given as a preventive treatment. In the second study, in patients with existing lesions, the therapeutic success rate was 83% (95%CI = 59-96%), which was significantly different from the success rate reached in the sham-treated patients (11%; 95%CI = 1-35%); the time to development of grade 3 mucositis was also significantly shorter in the sham-treated patients (p < 0.001). Our results strongly support the already available literature, suggesting that LEL is an effective and safe approach to prevent or treat oral mucositis resulting from cancer chemotherapy.

Efficacy of Low-Level Laser Therapy for Chronic Cutaneous Ulceration in Humans: A Review and Discussion

Chronic wounds, particularly venous ulcerations, are notoriously difficult to heal. Because current therapies are variable in their ability to induce complete healing, there remains a need to develop adjunctive treatments that can improve or accelerate the healing process. The use of low-energy lasers to stimulate wound healing has been pursued over many decades in studies of varying quality. This form of treatment has had high appeal due to its novelty, relative ease, and low morbidity profile. The authors reviewed the available published literature on low-level laser technology in an attempt to provide cumulative insight on the effect of this treatment for wound healing.

Influence of low‐energy laser in the prevention of oral mucositis in children with cancer receiving chemotherapy

This study assessed the use of low-energy laser in the prevention or reduction of the severity of oral mucositis. A randomized clinical trial was carried out. Patients from 3 to 18 years of age treated with chemotherapy or hematopoietic stem-cell transplantation between May, 2003 and February, 2005 were eligible. The intervention group received laser application for 5 days following the start of chemotherapy. The grade of oral mucositis was assessed by the WHO per NCI-CTC common toxicity criteria and the assessments were made on days 1, 8 and 15 by a trained examiner blind to the intervention. Sixty patients were evaluable for analysis; thirty-nine (65%) were males, 35 (58%) patients had a diagnosis of leukemia or lymphoma, and 25 (42%) had solid tumors. The mean age was 8.7 +/- 4.3 years. Twenty-nine patients were randomized in the laser group and 31 in the control group. On day 1, no patients presented with mucositis. On day 8, of 20 patients (36%) who developed mucositis, 13 of them were from the laser group and 7 from the control group. On day 15, of 24 patients (41%) who developed mucositis, 13 of them were from the laser group and 11 from the control group. There was no significant difference between groups concerning the grades of mucositis on day 8 (P = 0.234) or on day 15 (P = 0.208). This study showed no evidence of benefit from the prophylactic use of low-energy laser in children and adolescents with cancer treated with chemotherapy when optimal dental and oral care was provided.

Use of low-energy laser as adjunct treatment of alcohol addiction

Auricular acupuncture is a medical method that has been used in the treatment of alcohol addiction. In our study we decided to intensify this method by additional biostimulation of the whole organism. The aim of this study was the therapy of patients with alcohol dependence syndrome. Fifty-three alcoholics were treated with two types of laser stimulation in four sessions. Each session consisted of 20 consecutive daily helium-neon laser neck biostimulations and 10 auricular acupuncture treatments with argon laser (every 2nd day). The Beck Depression Inventory-Fast Screen (BDI-FS) was used to assess their frame of mind before the session and after 2 months of treatment. Moreover, beta-endorphin plasma concentration was estimated five times using the radioimmunoassay (RIA) method. Improvement in BDI-FS and increase in, beta-endorphin level were observed. These results suggest that laser therapy can be useful as an adjunct treatment for alcoholism.

Management of chemo- and radiotherapy induced oral mucositis with low-energy laser: initial results of A.C. Camargo Hospital

Background. Oral mucositis is a common complication of some malignancies treatment, causing therapeutic modifications due to patient's debilitation, which often interferes with the prognosis of the disease. Many attempts have been made to find an optimal treatment or preventive method to minimize the severity of oral mucositis. Several studies have shown good results with the use of low-energy laser, with the aim of accelerating the process of wound healing and promoting pain relief. Methods. Patients (n=18) who developed oral mucositis during chemotherapy and/or radiotherapy were submitted to low-energy laser applications until cessation of symptoms. Mucositis severity was scored by an oral mucositis scale based on clinical features and by an oral toxicity scale from the National Cancer Institute based on the ability to swallow; pain severity was scored by subjects on a visual analogue scale before and after the applications. Results. Immediate pain relief was achieved in 66.6% of the patients after the first application. Based on the functional scale, mucositis grade III (not capable to eat solids) was reduced in 42.85% of the cases. According to the scale based on the clinical features, mucositis grade IV (ulcerative lesions) was reduced in 75% of the patients that presented this grade of mucositis at the beginning of laser therapy. Conclusions. Low-energy laser was well-tolerated and showed beneficial effects on the management of oral mucositis, improving the quality of life during the oncologic treatment.

Effects of a low-power He-Ne laser on the healing of experimental colon anastomoses: our experience

Despite technical advances, the incidence of anastomotic leaks in elective colorectal surgery remains around 14%. Recent studies suggest that the use of low-energy lasers may enhance wound healing in different tissues in a selective, nondestructive manner. Based on these findings we have attempted to provide experimental background on the effects of a He-Ne laser during the early stages of healing in 155 colonic anastomoses performed on rats. The irradiation (external or endoscopical) ofthe anastomoses by repeated doses below 4 J/cm² suggest (1) the laser-induced enhancement of anastomotic healing can be obtained in both healthy colons or in situations in which anastomotic breakdown is more likely, such as colonic obstruction; (2) the photochemical effects observed can be transmitted through optic fibers; (3) energy densities above the range of 4 J/cm² show no benefit in wound-healing stimulation.

Effect of a helium-neon laser on pial microcirculation in rats

, laser action. Lasers, which have a photodynamic and biostimulatingac tion on tissues, are being increasingly used to study the morphological and functional changes in organs and tissues [2, 5, 8]. The use of lasers in microcirculatory research has made it possible to apply precise conditions of stimulation to different parts of tile microcirculatory bed [6] and also a means of assessing the microcirculation of the blood in vivo [7]. The use of low-energy lasers, inducing a biostimulating effect, is promising as a means of studying the effect of outside influences on vessels of the microcirculatory bed [i, 3]. Among these lasers, the heliumneon laser (H/~L) has achieved the most widespread popularity. The aim of this investigation was to study the effect of HNL on the microcirculatory bed of the pia mater and the microcirculation in rats in order to discover the sensitivity of arteriolar and venular microvessels to this agent at different ages of postnatal development.