Abstract
In vivo experimental study was conducted to investigate the effect of bone regeneration under the use of a bioactive glass-based composite as well as the use of laser irradiation in the presence of the bioactive glass-based composite. In 16 white non-inbred rats, with a body weight of 300–350 g the bioactive glass-based composite was implanted into the tibial metaphysis. Besides, 90 female rats of the Wistar line weighing 250–270 g underwent laser irradiation on an artificially created tibial bone defect filled with the bioactive glass-based composite. The period of observation lasted respectively 2 and 4 weeks. It was found that application of the bioactive glass promotes bone regeneration, which is noticeably enhanced with the use of low energy laser. The combining effect leads to a significant increase in bone regeneration and the expression of bone tissue metabolic markers: osteocalcin and alkaline phosphatase. The most pronounced effect of the laser on bone regeneration occurred at a wavelength of 810 nm, which opens up prospects for the use of this technique in clinical practice.
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