Chronic ankle instability is a condition that often occurs after a lateral ankle sprain. It affects daily activities, quality of life and can cause further ankle injuries. The purpose of this article is to systematically review and compare the effectiveness of physiotherapy methods and techniques, epidemiology, and risk factors of chronic ankle instability. A literature search was performed using the PubMed database for existing systematic reviews and meta-analyses. The results show that the prevalence of chronic ankle instability is 46% in people with a history of ankle sprains and is highest in adolescents. In addition, risk factors are poorly understood. Balance training has been shown to be the most effective among standalone treatments. It improves functionality, instability, dynamic balance, and health-related quality of life. Furthermore, a multimodal program is effective in improving self-reported ankle function. Vibration is a useful adjunct to exercise because it improves sensorimotor deficits. Joint mobilization is effective in increasing ankle dorsiflexion and improving balance. Despite the frequent use of external support, it has not been supported as a sole intervention.