Indicators help to determine the equivalence point in acid – base titrations (neutralization titrations). They show sharp color change with respect to change in pH. Commonly used indicators for neutralization titrations are synthetic in nature. They are found to posses hazardous effects in human body. The highly colored pigments obtained from plants are found to exhibit color changes with change in pH. In the present work, acid base titration has been performed by using natural indicators. The natural indicator is prepared from the ethanolic extract of Argyreia cuneata. Two acids (H2SO4 and CH3COOH) and two bases (KOH and NH4OH) were selected for acid base titration. 0.1N, 0.5N, 1N and 5N strength of these acids and bases were prepared. The end points obtained by the flower extract coincide with the end points obtained by standard indicators. Therefore, use of ethanolic extract of flower as an indicator is more economical and having the same accuracy of result as that given by synthetic indicator.