Use Of Dietary Supplements Research Articles

International expert consensus on micronutrient supplement use during the early life course

BackgroundGrowing evidence demonstrates that maternal nutrition is crucial for the health of the mother-to-be, and early life course of the offspring. However, for most micronutrients, guidelines are inconsistent. This Delphi study aimed to investigate the level of expert consensus on maternal nutrition and micronutrient needs during preconception, pregnancy and lactation.MethodsWe conducted a two-round web-based Delphi survey on various topics including general approaches to diet and supplement use, and existing guidelines. For the periods of preconception, pregnancy and lactation, questions focused on the importance and strength of evidence for supplement use with the following micronutrients for low- and high-risk populations: folic acid, choline, iodine, magnesium, calcium, iron, selenium, docosahexaenoic acid (DHA), and vitamins B1, B2, B6, B12, D and K.ResultsThirty-five experts participated in the panel, who were healthcare professionals (HCPs), researchers and joint HCP-researchers with expertise in nutrition, gynaecology and/or obstetrics. Panellists reached consensus on the importance of diet and dietary supplement use during pregnancy and agreed on the lack of clarity and consistency in current guidelines, and the need for education in these areas for HCPs, pregnant people and the general population. For general low-risk populations, there was consensus on the importance of supplement use with iron and vitamin D from preconception through lactation, with folic acid and iodine from preconception through the second and third trimesters, respectively, with DHA from the first trimester through lactation and with calcium during lactation. Panellists agreed that the evidence for supplement use with each of these micronutrients during these phases to improve outcomes and/or foetal development is strong, except for vitamin D (preconception), DHA (first trimester), and iron (both periods). There was also consensus that supplement use advice should be tailored for people following vegan/vegetarian diets, restricted diets due to food intolerances, obesity, polycystic ovary syndrome, diabetes mellitus, and previous nutrition-related pregnancy complications.ConclusionThe findings revealed robust consensus on various aspects of maternal nutrition, including the need for education, the lack of consistency in current guidelines on supplement use, the importance of supplement use across specific phases of pregnancy and the at-risk groups requiring tailored approaches.

Association Between Dietary Supplement Use and Academic Achievement Among University Students in the Kingdom of Saudi Arabia: A Cross-Sectional Study

Association Between Dietary Supplement Use and Academic Achievement Among University Students in the Kingdom of Saudi Arabia: A Cross-Sectional Study

Assessing Nutritional Knowledge and Physical Health Among Football Players: A Pilot Study from Three Sports Clubs in Western Romania.

Football players require optimal nutrition and physical fitness to enhance their performance and maintain their health. Understanding the relationships among nutritional knowledge, dietary habits, physical health, and substance use in athletes is essential for developing effective strategies. This study investigates these factors in male football players aged 16-33 years. The study involved 60 male football players from three teams in Liga4Arad. A mixed-methods approach was used, incorporating a self-developed pilot questionnaire and internationally validated instruments. The reliability of the questionnaire was confirmed using Guttman's λ2. The questionnaire assessed nutritional knowledge, eating habits, substance use, and physical health parameters, including body fat percentage and training frequency. Spearman's correlation was used to analyze the data and explore the interrelationships between these factors. It is important to note that the pilot questionnaire used in this study was self-developed and not previously validated in this specific context. Nutritional knowledge was positively correlated with healthier eating habits (ρ = 0.675, p < 0.001). Intensive training and higher physical activity levels were both associated with improved body composition and lower body fat (ρ = 0.341, p = 0.006). Supplement use was moderately correlated with alcohol consumption (ρ = 0.548, p < 0.001) and weakly correlated with smoking (ρ = 0.348, p = 0.007). The study highlights a strong relationship between nutritional knowledge and healthier eating habits among football players, as well as the significant role of frequent intense training in reducing body fat percentages and enhancing physical fitness. Additionally, the findings suggest a moderate association between dietary supplement use and alcohol consumption, underscoring the need for tailored interventions to address substance use and its impact on players' health behaviors and performance.

Nutrient Intake Among Lactating Women With Overweight and Obesity in Norway: A Comparison With the Nordic Nutrition Recommendations 2023.

During lactation, maternal requirements for many nutrients increase due to the physiological demands of breast milk production, reflected in dietary recommendations. BMI is negatively associated with dietary quality postpartum, and 40% of women in Norway have pre-pregnancy overweight and obesity. Currently, there is limited data on dietary intake among lactating women in Norway and whether they meet nutritional requirements. We aimed to evaluate the nutrient intake in a study sample of lactating women with overweight and obesity, compared with the Nordic Nutrition Recommendations (NNR 2023). In this cross-sectional analysis, we included baseline data from 112 lactating women with a pre-pregnancy BMI of 25-35 kg/m2, participating in a weight loss and breastfeeding promotion intervention trial in Oslo, Norway. Data were collected at 2 weeks postpartum (subject characteristics, anthropometry and dietary supplement use), at 7 weeks postpartum (dietary assessment) and post-weaning (retrospective dietary supplement use). Dietary data were obtained from a 4-day dietary record before randomisation to dietary treatment for weight loss. Nutrient intake was compared to the dietary reference values for lactating women in NNR 2023. Increased risk of inadequate intake of micronutrients was assessed as the proportion of women with intakes below the average requirement (AR), with and without dietary supplements. Mean ± SD BMI at 2 weeks postpartum was 30.7 ± 2.5 kg/m2. At 7 weeks postpartum the women reported a mean energy intake of 9.2 ± 2.0 MJ/day, with a higher intake of saturated fat and a lower intake of carbohydrate, dietary fibre and docosahexaenoic acid than recommended. The majority had an increased risk of inadequate intake of vitamin A (92%), folate (92%), vitamin D (84%), selenium (87%) and iodine (71%) from the diet alone. When dietary supplements were taken into account, ≥ 50% of the women still had an increased risk of inadequate intake of vitamin A, folate and selenium. The high proportion of lactating women with overweight and obesity failing to meet the newly updated Nordic Nutrition Recommendations highlights the need to raise awareness among new mothers and healthcare professionals about the increased maternal nutritional demands during lactation and hence, the importance of nutrient-dense diets.

The Association Between Dietary Supplement Use and COVID-19 Symptoms

The scientific evidence supporting recommendations for dietary supplement use to prevent or treat coronavirus disease 2019 (COVID‑19) is not well‑established. This cohort study investigates the relationship between dietary supplement usage and COVID‑19 symptoms among 27,181 adults tested for COVID‑19. Using data from surveys following COVID‑19 testing, conducted by the University of Arkansas for Medical Sciences, associations between dietary supplement usage, symptomatology, and COVID‑19 status were explored. The prevalence of supplement consumption among symptomatic individuals was significant, with non‑Hispanic (NH)‑White individuals showing higher usage rates. Among those testing positive for COVID‑19, mainly asymptomatic cases, dietary supplement usage was increased (7.8%), suggesting a proactive approach to supplementation. Symptomatic individuals with confirmed COVID‑19 also showed heightened dietary supplement usage (37.9%), indicating a response to perceived therapeutic benefits. Notably, respiratory symptoms such as cough (46.2%), fever (31.4%), and shortness of breath (8.9%) correlated consistently with increased dietary supplement usage across different time points. Despite limitations such as varying test sensitivities and potential selection biases, this study offers valuable insights into individual health‑seeking behaviors during the pandemic. Findings emphasize the importance of targeted public health interventions and education to address disparities in dietary supplement usage and promote evidence‑based approaches to dietary supplementation. Further research is warranted to understand better the motivations and implications of dietary supplement usage in the context of the pandemic.

A Pilot Study on Knowledge, Attitude, and Practice Regarding the Use of Dietary Supplements as Adjuvant Therapy for Glaucoma

Purpose: To find out knowledge, attitude, and practice among ophthalmologists regarding nutritional supplements in the management of glaucoma. Study Design: Cross sectional study. Place and Duration of Study: Lotus Eye Hospital and the College of Optometry. Methods: A questionnaire-based cross-sectional pilot study was conducted. All questions in the 4-section questionnaire were mandatory. A Google form was created to share the questionnaire with potential participants. The final questionnaire link was emailed, distributed, and posted on social media to ophthalmologists. Final analysis was done after the data was manually entered into an excel sheet. Chi-square test was used to find out any association of knowledge, attitude, and practice based on years of experience, gender, and place of practice. P value &lt; 0.05 was considered statistically significant. Results: Out of 156 ophthalmologists, there were 99 males and 57 females. The average age was 41.88±6.15 years. Only 57.5% had good to fair knowledge, 25% had a positive attitude towards the role of nutritional supplements in glaucoma management, and practice patterns showed that only 30% prescribed supplements. The commonly prescribed supplements were Lutein, Zeaxanthin, flavonoids, and Omega3. A statistically significant 73% of respondents worked in private hospitals and 27% in public hospitals (p=0.005). With standard glaucoma therapies, 58% of respondents with 6-10 years of experience did not prescribe nutritional supplements. Limitations of the study include included a relatively small sample of 156 ophthalmologists, limiting the generalizability of the findings to a broader population. The distribution of the questionnaire via email and social media may have introduced selection bias, as only those with internet access and willingness to participate were included.Reliance on self-reported responses may lead to response bias, as participants might overstate or understate their knowledge, attitudes, and practices. The study did not assess whether the use of nutritional supplements by the ophthalmologists led to improved patient outcomes, which limits the practical implications of the findings. Addressing these limitations in future studies, such as through larger sample sizes, randomized designs, and longitudinal approaches, could provide more robust and generalizable insights into the role of nutritional supplements in glaucoma management. Conclusion: The study results indicate that only 1 in 3 ophthalmologists administer supplements as adjuvant therapy for glaucoma. Randomized controlled trials of nutritional supplements as glaucoma adjuvant therapy can improve ophthalmologists' knowledge, attitude, and practice.

Nutrition for optimising immune function and recovery from injury in sports.

The immune system, sports injuries, physical activity and clinical sports nutrition are closely linked. Inadequate nutrition and intense stress in athletes increase the risk of immune dysfunction, injury and disease, while injury reduces the positive effects of physical activity, creating a vicious cycle affecting health and performance. Nutritional support is key to reducing the risk of injury, speeding up recovery and shortening rehabilitation. The intake of energy, protein, carbohydrates, fats and micronutrients should be adapted to the needs following injury. Quality nutrition is preferred over the use of dietary supplements, which are limited to cases of identified deficiencies (e.g. vitamin D or iron deficiencies). Health professionals with knowledge of clinical nutrition have a key role to play in injury prevention, treatment and rehabilitation, and nutritional interventions are an indispensable part of a holistic approach to athletes' health.

Prevalence and Pattern of Dietary Supplement Use in Bodybuilding Athletes

Introduction: Using sports supplements is a common strategy for improving athletic performance. The prevalence of using sports supplements among adolescent and young athletes has been increasing in recent years. Methods: This descriptive-analytical study was performed on 200 bodybuilding athletes. The data collection tool was a pre-made questionnaire. The questionnaire was distributed among the athletes by available methods and collected after filling out. The chi-square test, Fisher's exact test, and logistic regression model were used to analyze the data. Results: The prevalence of using sports supplements was 62.5% (n=125), with males accounting for 67.5% (n=135) of the consumers. Various forms of proteins (43.5%, n=87), vitamins (40.5%, n=81), and hormones (38.5%, n=77) were the most commonly recommended supplements by the coaches (58.4%, n=73) and other athletes (31.2%, n=9). The sports supplements have been considered to have no side effects by 16.8% (n=21) of the athletes; however, 19.2% (n=24) mentioned cardiac adverse events, and 13.6% (n=17) pointed to renal complications as potential consequences of supplement use. The results of statistical tests and a logistic regression model showed a statistically significant relationship between sex, age, education and income, and sports supplement use (p=0.001). Conclusion: According to the results of this current study, a significant proportion of bodybuilding athletes take sports supplements without being aware of the side effects. Therefore, it is necessary to develop an educational program to inform the population about the mechanism of action of supplements in the body and also educate athletes and coaches about the correct use, side effects, and irreversible consequences of improper supplements use.

Changes in Tendon Thickness After Chondrovita FIT® Supplementation in Elite Skaters: Findings from a Quasi-Experimental Study.

The use of dietary supplements is widespread in sports and fitness, with many products containing multiple ingredients. Among supplements often consumed to support musculotendinous health, collagen hydrolysate (CH) has gained popularity for its potential in improving joint comfort and function. This single-blind quasi-experimental study investigated the effects of a three-month oral supplementation with a specific CH-based product, Chondrovita FIT® (Bone Srl, Rome, Italy), on tendon structure in elite Italian skaters. Eighteen male and female elite skaters (mean age: 21 ± 3 years) participated, receiving daily pre-workout (4500 mg CH) and post-workout (2500 mg CH) doses. Tendon structure in the patellar and peroneal tendons was assessed using ultrasound imaging at baseline and post-supplementation. Results showed a significant increase in tendon thickness in both the patellar and peroneal tendons after supplementation, although no changes were observed in the tendon cross-sectional area. These findings suggest that Chondrovita FIT® supplementation may induce beneficial structural changes in tendons, potentially supporting tendon health and performance in high-load sports. However, further research is needed to confirm long-term effects and functional outcomes.

Risks Related to the Use of Dietary Supplements in the Light of Insufficient Legal Regulations and Low Public Awareness

In recent years, we have observed a dynamic development of the dietary supplements (SD) market in Poland has undergone a period of significant expansion and evolution. This is facilitated by the form of the products, the declared properties and the method of presentation, which includes advertising in mass media such as radio, television, press and the Internet. SDs contain mainly vitamins and minerals, as well as amino acids, fatty acids, fibre and other plant products. Their popularity and widespread use may raise a number of doubts. In Polish and European legislation, dietary supplements are classified as foodstuffs. Consequently, they are not subjected to the same rigorous testing procedures as medical products, which include assessments of potential interactions, side effects and durability. A substantial body of evidence attests to the fact that dietary supplements may contain undeclared substances or substances in doses that differ from those indicated by the manufacturer. It is therefore imperative to implement suitable quality standards and to highlight the issues pertaining to the regulatory framework governing dietary supplements.

Effects of anti-inflammatory dietary supplements on pelvic pain in females with endometriosis: A GRADE-assessed systematic review and meta-analysis of RCTs.

Endometriosis, the most perplexing gynecologic condition, impairs the quality of life because it is usually accompanied by persistent severe acyclic pelvic pain and infertility as its two main symptoms. The majority economic burden of endometriosis is due to infertility and pelvic pain. Therefore, alleviating pelvic pain in patients with endometriosis is a necessity. The present systematic review and meta-analysis aimed to summarize evidence about the effects of anti-inflammatory dietary supplements on pelvic pain in females with endometriosis. PubMed, Scopus, and Web of Science as online databases were systematically searched by relevant keywords up to December 2023. Randomized controlled clinical trials (RCTs) with either a parallel or crossover design conducted in adults with endometriosis were selected. Random effect analysis was used to run meta-analysis. Subgroup analyses were run to detect heterogeneity sources. Quality assessment was done by revised Cochrane Collaboration tool II. The certainty of evidence was evaluated by the GRADE tool. A significant decrease in pelvic pain following supplementation with anti-inflammatory dietary supplements was detected. Also, anti-inflammatory dietary supplements could significantly decline pelvic pain in patients with endometriosis when the age of the participants was ≥32 years, the duration of supplementation was >8 weeks, the type of intervention was anti-inflammatory vitamins, the stage of endometriosis of study participants was > II, and baseline body mass index (BMI) of the participants was >23 kg/m2. Use of anti-inflammatory dietary supplements in females with endometriosis results in a remarkable decrease in pelvic pain.

Effects of Marigold Extract and Carophyll Red on Growth, Body Color Development, Antioxidant Properties, and Innate Immunity in the Ornamental Fish Golden Severum (Heros efasciatus).

The body color state is an important determinant of the value of golden severum (Heros efasciatus)-a popular ornamental fish. The use of dietary supplements to improve the color development and health of this species is unexplored. Herein, the effects of marigold extract (MG) and carophyll red (CR) are examined on the growth, body color development, antioxidant properties, and innate immunity in golden severum. Fish were maintained under controlled water quality conditions (pH, temperature, and dissolved oxygen) and fed six experimental diets containing either 0% MG and CR, 1% MG, 2% MG, 5% MG, 0.5% CR, or 2% CR for five weeks. Both MG and CR significantly decreased lipid peroxide levels in hepatic tissues. In contrast, only MG enhanced the activities of reactive oxygen species (ROS)-scavenging enzymes (superoxide dismutase and catalase). Although MG and CR decreased the respiratory burst activity of splenic leukocytes, other innate immune parameters remained unchanged. Additionally, MG and CR stimulated body color development patterns in golden severum that reflect their unique coloring principles. The ROS-scavenging abilities of MG and CR appear to be related to their antioxidant activity. Hence, MG and CR at the optimal levels of 1.0% and 0.5%, respectively, can improve the body color of golden severum and protect against oxidative stress.

Review of Supplements That Patients Commonly Report Using for Dementia.

Dietary supplements are readily available over the counter in the United States and are used by the majority of older adults to address a variety of concerns and conditions. Many older adults report using dietary supplements for cognitive health-either to address memory loss or dementia or in efforts to prevent cognitive decline. Our objective for this narrative review is to summarize the available efficacy and safety data for several supplements commonly reported in our clinic as being used for symptoms of dementia. Using a validated survey instrument, we conducted a survey of patients in our tertiary referral center memory clinic population to assess for the most commonly reported supplements for cognition. In our review, we compare the strength of published medical and scientific evidence to advertising or other lay press claims made about the nine most reported supplements with the aim of providing a representation of general trends in this industry. We found little or no scientific evidence available to support the use of any of these substances to ameliorate memory loss or other cognitive symptoms. Although most appear safe in the studies conducted to date, several authors have highlighted the lack of Food and Drug Administration oversight in the supplement industry, raising concerns over unknown or undeclared contaminants in these over-the-counter products. This review will better prepare clinicians to discuss these considerations with their patients who are considering the use of dietary supplements.

Supplementation of Olive Oil and Flaxseed Oil on Blood Pressure and Inflammation in Healthy and At-Risk Adults: A Systematic Literature Review and Meta-Analysis.

Adding olive oil (OO) and flaxseed oil (FLO) to the diet has been reported to improve endothelial function and reduce inflammation. However, the efficacy of supplementing OO and FLO on blood pressure (BP) in normo-, pre-, and hypertensive stage 1 adults is uncertain. This study aimed to systematically review the literature on OO and FLO supplementation on BP and select inflammatory markers in healthy adults and adults at risk of hypertension. Four databases, PubMed, CINHAL, Web of Science, and Medline (Ovid), were searched from inception until October 2023 for randomized control trials (RCTs) comparing OO and FLO supplementation in normotensive or adults at risk of hypertension. The outcomes included were systolic blood pressure (SBP) and/or diastolic blood pressure (DBP) and at least one inflammatory marker, C-reactive protein (CRP), interleukin6 (IL6), or tumor necrosis factor alpha (TNFα). The risk of bias was assessed using version 2 of the Cochrane risk of bias tool for RCTs, publication bias visualization was performed using funnel plots, and meta-analysis was completed to generate average estimates of effects in 2024. Seventeen RCTs, comprising 14 studies on OO and 3 on FLO, met the inclusion criteria. Meta-analysis using a random-effects model reported no significant effect on SBP n=17 mean difference (MD) -0.48; 95% CI: -1.76, 0.80; p=0.65, I2=0%) and DBP (n=16, MD -0.47; 95% CI: -1.33, 0.39; p=0.65, I2=0%) or inflammatory markers, CRP (n=8, MD 0.11; 95% CI: -1.18, 0.40; p=0.98, I2=0%), IL6 (n=3, MD -0.15; 95% CI: -0.57, 0.27; p=0.87, I2=0%), and TNFα (n=3, MD-0.08; 95% CI: -0.12, -0.03; p=0.98, I2=0%). Longer-duration, higher-dose, and larger-scale RCTs are needed to better understand the efficacy of OO and FLO supplementation on BP. Further insight will better inform dietary supplement use for preventing hypertension.

The effect of quercetin and citrulline on cycling time trial performance.

There is growing interest in the use of nutrition and dietary supplements to optimize training and time-trial (TT) performance in cyclists. Separately, quercetin (QCT) and citrulline (CIT) have been used as ergogenic aids to improve oxygen (VO2) kinetics, perceived effort, and cycling TT performance. However, whether the combination of QCT and CIT can provide additive benefits and further enhance cycling performance production is currently unknown. We examined 28-days of QCT + CIT supplementation on TT performance and several performance measures (i.e. mean power, VO2, respiratory exchange ratio (RER), and rate of perceived exertion (RPE)). Forty-eight highly trained cyclists were assigned to one of four supplementation groups: (1) QCT + CIT (QCT: 500 mg, CIT: 3000 g), (2) QCT (500 mg), (3) CIT (3000 mg), or (4) placebo (3500 mg of a zero-calorie flavored crystal light package). Supplements were consumed two times per day for 28 consecutive days. Participants performed a 20-km cycling time-trial race, pre- and post-supplementation to determine the impact of the combined effects of QCT + CIT. There were no potential benefits of QCT +CIT supplementation on TT performance and several performance measures. However, there was an improvement in VO2 from pre-to-post-supplementation in QCT (p = 0.05) and CIT (p = 0.04) groups, but not in the QCT+CIT and PL groups. QCT + CIT does not seem beneficial for 20-km TT performance; further exploration with a focus on an increase in cycling duration or QCT+CIT combined with additional polyphenols may amplify any perceived bioactive or metabolic effects on cycling performance. The efficacy of QCT + CIT supplementation to improve cycling performance remains ambiguous.

Dietary supplementation use for outpatient treatment in children: A cross-sectional study

Dietary supplements (DSs) are commonly used supplements among children to support disease treatment, however, overuse and inappropriate prescription of outpatient DS can negatively affect health and treatment costs. This study aimed to evaluate DS use in outpatient treatment in children. The present study used a cross-sectional descriptive retrospective method based on data from 188,579 outpatient prescriptions of children for 1 year. DSs were commonly prescribed in pediatric patients ≤5 years old (63.48%) with diagnosing respiratory, infectious, and gastrointestinal diseases (>50%). DS costs account for a high proportion (24.86%) of total outpatient prescription costs. In addition, pediatric prescriptions containing one DS product (88.16%) showed a higher rate than prescriptions containing two DS products (11.84%) with the main ingredients being vitamin D3 (80.55%), vitamin B6 (63.01%), vitamin B1 (60.22%), and vitamin B2 (59.04%), and calcium (51.0%). The majority of DS products contained multivitamins (69.52%) with DS containing ≥5 vitamins of 59.04% and DS containing 2-4 vitamins of 10.48%. Besides, non-compliance with DS prescribing guidelines for age (21.38%), dose (14.13%), and both age and dose (5.54%) was found primarily in highly prescribed DSs (vitamin-amino acid-mineral ingredients), pediatric patients <2 years old, prescriptions containing one DS product or multivitamins, and respiratory disease group (J and R04-09 ICD). The univariate and multivariate regression analyses showed that vitamin-mineral products and groups <2 years old were significantly associated with guideline-adherent DS prescribing for age and/or dose. Meanwhile, foreign DSs and vitamin-mineral ingredients of prescription showed significant associations with guideline-adherent DS prescribing for age or dose. Instructions for DS use regarding recommended age and maximum dosage may not be carefully considered by doctors due to belonging to an over-the-counter medicine group. Therefore, there is a strong need for a national public policy to prevent and control overprescribing and inappropriate prescribing of DS.

Improved uptake of anthocyanins-loaded nanoparticles based on phenolic acid-grafted zein and lecithin

Anthocyanins (ACNs) exhibit various physiological activities but have low bioavailability. This study aimed to improve cellular uptake and permeability of ACNs by utilizing phenolic acids grafted zein and lecithin (ZLAs) as the carrier. With the highest grafting rate achieved in rosmarinic acid (RA)-zein at 39.79 ± 0.40 % using alkali treatment, the grafted zein samples were characterized through spectroscopy, NMR, and analysis of physicochemical properties. Ferulic acid (FA)-ZLAs exhibited the smallest particle size (69.72 ± 0.50 nm) and PDI value of 0.206 ± 0.012. Multi-spectroscopy indicated hydrogen bonding and hydrophobic forces were the major forces to stabilize ACNs. Moreover, carrier binding including electrostatic interaction effectively enhanced processing, thermal degradation, color, and gastrointestinal stability. In Caco-2 monolayers, FA-ZLAs significantly improved cellular transport efficiency, resulting in up to a 1.9-fold enhancement. RA-ZLAs exhibited the strongest antioxidant activity. This work proposes a feasible strategy for stabilizing ACNs and propelling their use in dietary supplements.

Naturally Occurring Microbiota-Accessible Borates: A Focused Minireview

Recently, we discovered and proved the essentiality of organic boron species (OBS), such as borate–pectic polysaccharides and borate–phenolic esters, for healthy symbiosis (HS) between microbiota and human/animal (H/A) host. The essentiality of OBS will provide new options for B supplementation in H/A nutrition for a healthy and long life. New knowledge on the essentiality of naturally occurring microbiota-accessible borate species for HS between microbiota and H/A host will allow the use of natural B-based dietary supplements to target the H/A microbiome (the gut, skin, oral, scalp, and vaginal microbiome). In the literature, there is evidence that certain bacteria need B (autoinducer-2 borate) for communication and our preliminary data show that HS takes place when the colonic mucus gel layer contains B. Subsequently, OBS become novel prebiotic candidates and target the colon as novel colonic foods.

Biomarker-Guided Dietary Supplementation: A Narrative Review of Precision in Personalized Nutrition.

Background: Dietary supplements (DS) are widely used to address nutritional deficiencies and promote health, yet their indiscriminate use often leads to reduced efficacy, adverse effects, and safety concerns. Biomarker-driven approaches have emerged as a promising strategy to optimize DS prescriptions, ensuring precision and reducing risks associated with generic recommendations. Methods: This narrative review synthesizes findings from key studies on biomarker-guided dietary supplementation and the integration of artificial intelligence (AI) in biomarker analysis. Key biomarker categories-genomic, proteomic, metabolomic, lipidomic, microbiome, and immunological-were reviewed, alongside AI applications for interpreting these biomarkers and tailoring supplement prescriptions. Results: Biomarkers enable the identification of deficiencies, metabolic imbalances, and disease predispositions, supporting targeted and safe DS use. For example, genomic markers like MTHFR polymorphisms inform folate supplementation needs, while metabolomic markers such as glucose and insulin levels guide interventions in metabolic disorders. AI-driven tools streamline biomarker interpretation, optimize supplement selection, and enhance therapeutic outcomes by accounting for complex biomarker interactions and individual needs. Limitations: Despite these advancements, AI tools face significant challenges, including reliance on incomplete training datasets and a limited number of clinically validated algorithms. Additionally, most current research focuses on clinical populations, limiting generalizability to healthier populations. Long-term studies remain scarce, raising questions about the sustained efficacy and safety of biomarker-guided supplementation. Regulatory ambiguity further complicates the classification of supplements, especially when combinations exhibit pharmaceutical-like effects. Conclusions: Biomarker-guided DS prescription, augmented by AI, represents a cornerstone of personalized nutrition. While offering significant potential for precision and efficacy, advancing these strategies requires addressing challenges such as incomplete AI data, regulatory uncertainties, and the lack of long-term studies. By overcoming these obstacles, clinicians can better meet individual health needs, prevent diseases, and integrate precision nutrition into routine care.

Trends and Motivations in Dietary Supplement Use Among People with Diabetes: A Population-Based Analysis Using National Health and Nutrition Examination Survey Data from the 2009-2020 Period.

Dietary supplements have gained attention among people with diabetes as an alternative and complementary treatment, yet there is a limited understanding of supplement use and the motivations behind it. Data from the National Health and Nutrition Examination Survey (NHANES) from the 2009-2020 period were analyzed, including data on 5784 people with diabetes aged 20 years or older. Dietary supplement use was self-reported. Trends in supplement use were examined across three periods: 2009-2012, 2013-2016, and 2017-2020. Statistical analyses were conducted while considering NHANES's complex survey design to provide nationally representative estimates for the general noninstitutionalized population of the United States. A total of 61.72% of individuals reported using dietary supplements with a notable increase over time. Supplement users were generally older, more likely to be female, better educated, and had superior blood glucose control with lower smoking rates compared to non-users. Common supplements included multivitamins, multimineral supplements, vitamin D, calcium, zinc, vitamin C, and fish oil. Only 44.58% of individuals used dietary supplements based on medical advice, with the rest opting for self-directed usage. The primary specific health reasons for supplement use were to improve bone health and heart health and enhance the immune system. Dietary supplement use is prevalent among people with diabetes, and most diabetic supplement use is self-directed, which reflects a growing trend toward complementary therapies. Healthcare providers are encouraged to inquire about patients' use of supplements and offer appropriate guidance as an integral component of comprehensive diabetes management.