Use Of Detachable Balloons Research Articles

Abstract Number ‐ 211: Flow Diversion in Direct Carotid‐Cavernous Fistulas: Case Report and Literature Review

Introduction Direct carotid‐cavernous fistulas (dCCF) are acquired, abnormal high‐flow connections between the internal carotid artery and cavernous sinus. Interventions are often required due to the high risk of incipient morbidity and mortality if left untreated. Treatment approaches have rapidly evolved over time, and have included the use of detachable balloons, liquid embolic agents, and coil embolization through transarterial, transvenous, or combined approaches. Case series level data support an emerging role for the use of flow diversion (FD) as a stand‐alone or adjunctive treatment in dCCFs. We describe a case of FD use as an adjunctive treatment in a patient with a treatment‐resistant dCCF, and review the literature on FD use in dCCF. Methods We describe the clinical course, imaging findings, and outcomes of a 25‐year old patient who presented with a traumatic carotid‐cavernous fistula requiring multiple interventions. We also performed a literature review of Pubmed and Embase databases using combinations of MeSH and key terms to include all relevant full‐text publications of FD use in the treatment of dCCFs, up to and including February 2022. Results Our patient achieved angiographic cure and significant improvement in symptoms at 6‐month follow‐up. A total of 24 papers were identified and included, for a total number of 53 cases (23 male, 23 female, 7 unspecified). The median age of patients was 44 years (Interquartile range (IQR) 23–62). The etiology of the dCCF was traumatic (acute or as a delayed presentation) in 31 cases (58%), spontaneous in 10 cases (19%), and iatrogenic in 12 cases (23%). FD was the primary mode of treatment of the CCF in approximately half of cases (27, 51%), and was a stand‐alone treatment modality in one third of cases (18, 34%). The median number of FD devices used on initial treatment was 1 device, though retreatment was needed in 42% of cases.Angiographic resolution was achieved in 90% of cases at a median follow‐up duration of 6 months.One half of all patients had complete resolution of symptoms and a further third noted clinical improvement in at least some of their symptoms. In 10% of cases, symptoms persisted, or other complications developed that were attributed to concurrent injuries. Conclusions Treatment approaches for dCCFs have evolved over time as safer and more effective treatments become available. There is an emerging role for FD as a safe stand‐alone or adjunctive treatment option for dCCFs. Our case further supports its role in treatment‐resistant fistulas with high‐risk features. As treatment approaches continue to evolve, prospective randomized data is needed to better establish the role of flow divertors among the hierarchy of available treatment options for dCCFs.

Flow Diverters as Useful Adjunct to Traditional Endovascular Techniques in Treatment of Direct Carotid-Cavernous Fistulas.

Direct carotid-cavernous sinus fistulas (CCFs) are high-flow arteriovenous shunts that are typically the result of a severe head injury. The endovascular treatment of these lesions includes the use of detachable balloons, coils, liquid embolic agents, and covered stents. To minimize the chance of treatment failure and subsequent complications, endoluminal reconstruction using a flow-diverting stent may be added to the treatment construct. We present 3 cases and review the existing literature. Three patients with direct traumatic CCFs were treated with either coils, coils and Onyx, or a detachable balloon, followed by placement of a flow-diverting stent for endoluminal reconstruction. All 3 cases had complete angiographic occlusion of the CCFs and recovered clinically. No complications were observed. We believe that endovascular coil or balloon occlusion of the fistula from either a transvenous or transarterial approach followed by flow diversion may be an appropriate treatment for direct CCFs. This addition of a flow diverter may facilitate endothelialization of the injury to the internal carotid artery.

Transarterial Treatment of Direct Carotid Cavernous Fistulas with the Assistance of Undetachable Balloons

Directed carotid cavernous fistula means high blood flow shunts between the internal carotid artery and the cavernous sinus. Obstructing the abnormal shunt between the internal carotid artery and the cavernous sinus while preserving the internal carotid artery is the key role in fistula treatment. Transarterial balloon embolization is currently the gold standard treatment for most of the carotid cavernous fistulas. But there are still some technical difficulties in the use of detachable balloon to treat carotid cavernous fistulas. Here, we describe undetachable balloon-assisted technique in the embolization of three patients who got complete immediate occlusion of the shunt and preserved the internal carotid artery at the same time.

Use of detachable balloon in the treatment of arteriovenous fistula at a teenage case

In this article, we present a teenage female with a traumatic, distal femoral arteriovenous fistula (AVF). She was admitted to our cardiovascular clinic with the complaints of swelling, pain, cyanosis and ulceration at her right lower extremity. She had a history of gun shot injury 10-years ago. A skin scar was observed at this region due to surgery. Physical examination revealed swollen superficial varicose veins and ulceration of the right lower extremity. Heart failure was absent. We suspected an AVF with clinical findings. The high-flow fistula was diagnosed using multi-dedector computed tomography and confirmed on angiography. The fistula was successfully embolized with the detachable balloon technique.

Evolution of intracranial aneurysm treatment: From Hunterian ligation to the flow diverter

Background: Intracranial aneurysm rupture has the highest levels of mortality and morbidity among all stroke types. To answer the question of how and why different well-established and novel treatment techniques were developed, it is crucial to understand the historic hurdles and breakthroughs in intracranial aneurysm treatment over the years. Methods: Literature review was carried out using PubMed and the electronic database of Surgical Practice. Relevant articles were retrieved for further appraisal. Results: The neuro-endovascular treatment field has evolved from the use of detachable balloons or coils to the use of bioactive coils, balloon test occlusion, the balloon- and stent-assisted techniques, and the flow-diverting stent. The application of intraoperative indocyanine green angiography has also improved microsurgical treatment in recent years. Conclusions: Advances in endovascular technology have made coiling the cornerstone of intracranial aneurysm treatment. However, the roles played by different endovascular tools need to be better understood.

Comparison of the Risk of Oculomotor Nerve Deficits between Detachable Balloons and Coils in the Treatment of Direct Carotid Cavernous Fistulas

Transarterial balloon embolization used to be the preferred method for treating DCCFs; however, a strayed, overinflated, or migrated balloon may lead to oculomotor palsy. This investigation compared the use of detachable balloons and GDCs, which were previously used only in cases of balloon-technique failure and are now increasingly used as a first-line treatment for DCCFs, in terms of the risk of oculomotor nerve deficit, mortality/morbidity, and initial angiographic results. Among 48 patients with DCCFs treated with endovascular embolization at our institution between March 2004 and May 2009, 38 patients were included in this review. Patients who underwent trapping procedures, a second intervention within 2 weeks, or any procedure that included n-BCA infusion were excluded. Twenty of the enrolled patients were treated with transarterial balloons and the other 18, with GDCs. Five patients (25%) in the balloon group and none in the coil group had oculomotor nerve deficits within 2 weeks. The rate of procedure-related oculomotor nerve deficit was significantly higher in the balloon group than in the coil group (P = .048). There were no significant differences in terms of procedure-related mortality/morbidity or initial angiographic results between the 2 groups. The risk of procedure-related oculomotor nerve deficit in the treatment of DCCFs was significantly lower when using a GDC than with a detachable balloon. GDCs may, therefore, be considered as feasible, effective, and safe for DCCFs as detachable balloons.

Endovascular treatment of a direct post-traumatic carotid-cavernous fistula with electrolytically detachable coils

Carotid-cavernous fistulae are abnormal communications between the internal carotid artery and venous compartments of the cavernous sinus. Fistulae are uncommon but well-documented sequelae of craniofacial trauma. The characteristic clinical presentation includes ocular pain, chemosis, exophthalmus and visual disturbances. We report on a 28-year-old man with a history of severe craniocerebral injury, including multiple craniofacial fractures resulting from a fall from a height of approximately 6 meters, who was surgically treated one year ago. Two months before presentation, the patient began to exhibit progressive chemosis, proptosis, eyelid swelling, diplopia and exophthalmus. Computerized tomography and computerized tomographic angiography revealed findings consistent with a carotid-cavernous fistula of the right side of the cavernous sinus with dilatation of the right ocular vein. Digital subtractional angiography of the right internal carotid artery revealed a fistula between the cavernous part of the artery and the right cavernous sinus. There was only minimal blood flow in the supraclinoid part of the internal carotid artery because of the high pressure within the fistula. Our decision was to try to occlude the fistula by means of endovascular embolization. The origin of the fistula in the internal carotid artery was successfully obliterated with seven electolytically detachable coils. Control digital subtractional angiography at the end of the procedure demonstrated minimal residual flow through the fistula. Two months after the treatment, angiographic control revealed complete obliteration of the fistula. Clinical examination showed total resolution of signs and symptoms of a carotid-cavernous fistula. Endovascular transarterial embolization of carotid cavernous fistulae is a widely accepted, safe and successful treatment option. In the case that we describe we occluded the fistula and right cavernous sinus with electrolytically detachable coils that we could place into the sinus. Other endovascular treatment options include the use of detachable balloons, stent placement, transvenous embolization or surgical ligation of the fistula.

Endovascular Management of Cerebral Aneurysms

During the last decade, the field of endovascular surgery for the treatment of neurovascular disorders in general, and for cerebral aneurysms in particular, has undergone tremendous growth. As new technologies are developed and more experience is gained by trained endovascular therapists, more and more lesions will be able to be treated by less invasive methods. Improvements in catheter, guidewire and delivery system design, the development of various embolic agents and the technical advancements in imaging equipment have all contributed to the advancement of the field. Today, the endovascular treatment of cerebral aneurysms is a reliable, reproducible and well-accepted technique. Presently, most endovascular aneurysm treatments involve the use of detachable balloons and/or metallic coils. Detachable balloons are primarily used for deconstructive procedures or aneurysm neck protection. Detachable coils varying in size, length, flexibility, and configuration can now be reliably placed within an aneurysm and detached either mechanically or by electrolysis in a controlled fashion. The evolving techniques of endovascular aneurysm treatment including the development and use of precipitates, stents of various designs, neck protection and remodeling, aneurysm liners, liquid polymers, hydrogels, aneurysm neck protection, micro-anastomoses, bioactive manipulations to endovascular devices as well as real-time three-dimensional imaging will be discussed.

Pediatric congenital vertebral artery arteriovenous malformation

Vertebral arteriovenous fistulas are rare in children and the congenital form has been seldom reported in the literature. Prior to using endovascular therapy techniques, only surgery was the main treatment. The most common endovascular treatment is through the use of detachable balloons. This report describes the clinical and radiological findings of a congenital vertebral artery fistula in a 20-month-old child. Balloons could not be safely employed; therefore, embolization was performed with Guglielmi detachable microcoils. We review the history and treatment of these lesions, their clinical presentation, and imaging features, including their outcome, with particular attention to the pediatric population.

Endovascular Treatment of Acute Carotid Blow-out Syndrome

JVIR 2000; 11:1184–1188 CAROTID blow-out syndrome is a rare but life-threatening complication of head and neck surgery for malignant disease. Various etiologic factors relating to surgery and adjuvant therapy have been implicated. The reported mortality rates for this condition range from 9% to 100%, with an average of 40% (1). Emergency treatment usually involves surgical ligation of the common carotid artery (CCA) or internal carotid artery (ICA), and major neurologic complications occur in approximately 60% of patients (2). Endovascular occlusion of the carotid artery with use of detachable balloons may improve patient outcomes; an 89% survival rate with no major procedural neurologic morbidity was reported recently (2). Covered and uncovered metallic stents have been used to exclude carotid pseudoaneurysms in the elective situation (3–5). We report a case of acute carotid blow-out syndrome managed successfully with placement of a covered stent in the ultra-emergent situation. This allowed control of acute hemorrhage while preserving the carotid artery.

ENDOVASCULAR THERAPY OF TRAUMATIC CAROTID-CAVERNOUS FISTULAS

Traumatic carotid-cavernous fistulas (CCF) are capable of causing a large variety of signs and symptoms, including visual loss, glaucoma, chemosis, exophthalmos, and orbital cranial nerve palsies. The high pressure in the veins that normally drain the globe can cause them to engorge and produce local compression of adjacent structures. At present, endovascular closure of the fistula is the treatment of choice, particularly in patients with progressive neurologic deterioration. Endovascular repair of CCF most commonly involves the use of detachable balloons, although coils are also used. Effective closure of the fistula leads to rapid resolution of the symptoms.

Clinical Results and Complications of Endovascular Treatment for Intracranial Aneurysms

Thirty-two patients with intracranial aneurysm were treated via the endovascular approach and clinical results and complications were accessed. The aneurysms were on the anterior circulation, posterior circulation and feeding artery of AVM in 17, 12 and three patients respectively. In 17 (anterior circulation aneurysm), 12 patients underwent parent artery occlusion. There were two complications: cerebral embolism due to premature detachment of balloons and cerebral infarct due to parent artery occlusion. In 12 (posterior circuration aneurysm), four patients had complications: three infarcts due to parent artery occlusion and one aneurysmal bleeding at the interventional procedure. Coil compactions occurred in four cases. There were no complications in cases associated with AVM. Use of detachable balloons for intra-aneurysmal occlusion and intra-aneurysmal embolisation for partially thrombosed giant aneurysm tends to result in ischemic lesions where patient outcome is poor. We must pay attention to avoid these complications even though intra-aneurysmal embolisation using microcoils is currently performed safely.

Percutaneous Embolotherapy of Adolescent Varicocele: Results and Long-term Follow-up

The authors evaluated the technical success and immediate and long-term results of percutaneous varicocele embolotherapy in the adolescent population. Fifty-nine adolescent patients were referred for outpatient spermatic venography and possible varicocele embolotherapy. Embolization was attempted with use of detachable balloons, coils, "sandwiched" dextrose, or a combination of these techniques. Data regarding follow-up were obtained through telephone interviews or mailed questionnaires. The technical success rate for spermatic vein occlusion was 90%. Follow-up, obtained in 79% of the patients, ranged from 6 months to 8.75 years (mean, 4 years). Thirty-nine of 42 patients (93%) reported disappearance (n = 31) or only a slight, asymptomatic residual varicocele (n = 8). Three patients reported a recurrence of their varicocele. Complications occurred in three of 59 cases (5%), none had any long-term sequelae. In six cases, embolization was not feasible because of multiple collateral vessels or venous spasm. Given the convenience of performing the procedure on an outpatient basis, the rapid recovery time, and long-term success and complication rates comparable to those with surgical ligation, we believe spermatic venography and percutaneous embolization is the treatment modality of choice for adolescent varicocele.

Intracranial aneurysms: interventional neurovascular treatment with detachable balloons--results in 215 cases.

Patients with complex or surgically difficult intracranial aneurysms are being treated with interventional neurovascular techniques. With neuroleptic anesthesia and a transfemoral femoral approach, a silicone micro-balloon can be flow directed through the intracranial circulation, guided directly into the aneurysm, and detached. The aneurysm is thus eliminated from the circulation, and the parent artery is preserved. For broad-based or ectatic aneurysms, test occlusion followed by permanent occlusion of the aneurysm and parent vessel can be performed. Since 1981, 211 patients with 215 aneurysms, including 177 cases involving the anterior and 38 cases involving the posterior circulation, have been treated with this technique. In 127 cases (59.1%), the parent vessel was occluded; in 88 cases (40.9%), primary occlusion of the aneurysm was achieved with preservation of the parent artery. Therapy-related complications included 21 deaths (9.8%) and 16 strokes (7.4%). Follow-up examinations were performed at 1, 3, and 12 months after treatment, and follow-up ranged from 5 months to 9 years. In patients in whom standard surgical therapy fails or for aneurysms in surgically inaccessible anatomic locations, interventional techniques that make use of detachable balloons may be a useful therapeutic alternative.

Subtemporal Transdural Use of Detachable Balloons for Traumatic Carotid-Cavernous Fistulas

Endovascular use of detachable balloons has revolutionized the management of carotid-cavernous fistulas so that the goals of angiographic elimination of fistula and preservation of carotid patency can usually be achieved nonsurgically. Certain circumstances of flow dynamics and anatomy, however, make an endovascular approach difficult for even an experienced interventional neuroradiologist. Fistulas involving the posterior carotid wall at its proximal cavernous entry and the anterior carotid wall in its initial horizontal intracavernous segment, as well as very low flow fistulas at other sites, have posed particular problems. Three patients with such traumatic fistulas whose endovascular treatment failed were managed by the direct transdural introduction of balloons. Intraoperative angiography was accomplished with open internal carotid artery (ICA) catheterization and the use of a portable C-arm with a 6-in. image intensifier. After temporal craniectomy and subtemporal exposure, the course of the cavernous ICA was mapped out with spinal needles and the site of the fistula was localized by intraoperative angiography. An incision was then made in the lateral wall of the cavernous sinus, and latex balloons were manually introduced via a 7 French introducer sheath. The balloons were inflated under angiographic control and detached when the fistula was obliterated. This simple technique was initially successful in three patients; the fistula was eliminated with preservation of carotid patency. One patient suffered a recurrence of his fistula 2 months postoperatively while lifting weights, and one patient developed a new 3rd nerve palsy after operation.

Treatment of Direct Carotid-Cavernous Fistulas with Detachable Balloons

Experience with transarterial treatment of 14 direct carotid-cavernous fistulas using the Debrun technique with detachable balloons manually tied to the catheter is reported. Ten of the fistulas were occluded by balloons with concomitant occlusion of the internal carotid in one case. Another fistula closed spontaneously in connection with the embolization procedure. Three fistulas were treated with surgical trapping after recurrence. The transvenous approach was attempted in three cases but failed. Four complications occurred, two with clinical consequences as the patients developed neurologic deficits. Except in four cases with persistent or slowly regressing orbital palsies all signs and symptoms of the fistula disappeared after successful occlusion. The use of detachable balloons for selective occlusion is in experienced hands a rather safe and simple method with good results. Large fistulas offer most problems, and to avoid progression in fistula size the treatment should be undertaken as soon as possible after diagnosis.

Use of detachable balloons for proximal artery occlusion in the treatment of unclippable cerebral aneurysms

Of 68 patients with unclippable aneurysms treated by proximal artery occlusion with detachable balloons, permanent occlusion was achieved in 65; of these patients, 37 had carotid artery aneurysms below the origin of the ophthalmic artery, 21 had aneurysms arising from the supraclinoid portion of the carotid artery, six had basilar trunk aneurysms, and one had a distal vertebral aneurysm. Examination for treatment selection included assessment of the circle of Willis by compression angiography and xenon blood flow studies, with the ultimate evaluation being test occlusion under systemic heparinization with the balloon temporarily placed in the desired position. Of 67 patients who underwent a formal occlusion test, eight with carotid artery aneurysms did not initially tolerate the occlusion test, and ischemic signs disappeared instantaneously with deflation and removal of the balloon. During test occlusion, two additional patients had ischemic events that proved to be embolic; these reversed immediately upon balloon deflation. Of the 65 patients in whom permanent occlusion was effected by detachable balloon, there were nine instances of delayed cerebral events. One of these was a seizure leading to respiratory arrest and resuscitation 3 days following occlusion in a patient who had presented with seizures. The other eight cases were delayed ischemic events; seven were completely reversed and one patient had residual weakness in one leg (1.5% permanent morbidity). Extracranial-intracranial bypass procedures were performed in 25 of the 65 cases. All aneurysms of the carotid artery below the level of the ophthalmic artery presented angiographic proof of complete thrombosis. Ten of 21 aneurysms arising from the supraclinoid portion of the carotid artery were completely thrombosed by proximal occlusion alone, without additional trapping procedures. Similarly, in three of six basilar trunk aneurysms, proximal occlusion alone initiated complete aneurysm thrombosis without trapping. The conclusion is that proximal balloon occlusion for unclippable cerebral aneurysms is a convenient, safe, and effective way of producing arterial occlusion in these cases.

Port wine nevus associated with ipsilateral saccular aneurysms: Treatment by intraarterial balloon trapping

A 21-year-old woman with a port wine nevus presented with ipsilateral monocular visual loss. A computed tomography scan of the brain revealed a round suprasellar mass. Angiography demonstrated aneurysm of the right external carotid artery, and petrous, cavernous, and giant ophthalmic internal carotid aneurysms. Four detachable balloons were deployed with arteriographic guidance, resulting in occlusion of the right carotid artery. The association of aneurysms and phakomatoses is discussed. The use of detachable balloons in the treatment of nonresectable aneurysms represents a safe and advantageous option. The use of detachable balloons for carotid occlusion has proven to be an effective modality in the treatment of giant supraclinoid and carotid-cavernous aneurysms. Giant intracranial aneurysms have been surgically treated with carotid ligation proximal to the aneurysm and by direct approach using microsurgical technique. In cases in which direct ligation is not possible balloon occlusion represents an effective alternative. This case illustrates treatment by carotid trapping performed entirely with intraarterial balloons. In addition the association of saccular aneurysms in a patient with a port wine facial nevus is reported.