Cosmetic Use Research Articles

Fibrosing Frontal Alopecia: A comprehensive study to understand its etiology

Objective: To analyze the latest data on the etiology, mechanisms, clinical signs, diagnostic methods and therapeutic approaches for Fibrosing Frontal Alopecia (FFA). Methods: Systematic review organized around five phrases: formulation of the guiding question and the acronym PICO, search for articles and studies in online databases, selection and review of studies, critical evaluation of the material in the selected articles and interpretation of the results. Bibliographic Review: Fibrosing frontal alopecia is a form of acquired primary cicatricial alopecia characterized clinically by a recession of the frontotemporal line, often accompanied by eyebrow alopecia. Its pathophysiology involves immunological, genetic, hormonal, photoexposure, cosmetic use, environmental factors, trauma and stress mechanisms. The diagnosis is made clinically, through physical examinations and trichoscopy, and can be complemented with biopsy and optical coherence tomography. Conclusion: As this is a relatively new pathology, more research is still needed to better understand the disease and establish more effective treatments.

Antioxidant activities of sea buckthorn polysaccharides and their potential application in cosmetic industry

BackgroundMany natural polysaccharides have been reported to protect against skin aging through antioxidant pathways, but sea buckthorn polysaccharides have been less well studied in terms of antioxidant activity, and the related studies are not well developed. ObjectiveBy examining the chemical structure of sea buckthorn polysaccharides, this research aimed to offer a scientific foundation for their use in cosmetics and explore the in vitro antioxidant potential of these polysaccharides. Materialsand Methods: We made SP (sea buckthorn crude polysaccharide) using both hot water extraction and ultrasonic extraction. Then, we used the anion exchange method to separate and purify it to get three different polysaccharides: SPA (polysaccharide eluted from deionized water), which is a neutral polysaccharide, and SPB (polysaccharides eluted from 0.1 M NaCl) and SPC (polysaccharide eluted from 0.2 M NaCl), which are acidic polysaccharides. The characteristics of the four polysaccharides (SP, SPA, SPB and SPC) were determined using high-performance gel permeation chromatography (HPGPC), high-performance liquid chromatography (HPLC), Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and x-ray diffractometry (XRD). In vitro antioxidant assays were used to test their antioxidant activities. ResultsThe in vitro antioxidant assay showed that the four sea buckthorn polysaccharides (SP, SPA, SPB, and SPC) were good at getting rid of superoxide anion and DPPH radicals, especially ABTS radicals. They were also better at getting rid of free radicals than VC at low concentrations, and they were also good at reducing other molecules. ConclusionThese results showed that sea buckthorn polysaccharide has certain antioxidant activity; therefore, sea buckthorn polysaccharide has a strong potential to be applied in antioxidant and anti-aging functional cosmetics.

Nutritional and Medicinal Properties of Microbial Oil

Plant and animal oils and fats currently dominate the edible oil market, but a new sustainable alternative of lipids from single-celled organisms has become advantageous in human nutrition and pharmacy. Single-cell oils (SCOs) are lipids biosynthesized and accumulated in the lipid bodies of oleaginous species of bacteria, yeasts, molds, and algae. The review has investigated SCOs’ composition, with a detailed review of the described beneficial impact in medicine, cosmetics, pharmacy, and nutrition. Although microbial oil has been known for more than 100 years, it was not applied until the 21st century, when commercial SCO production for human use started and administrative regulations governing their use were completed. This article discusses the applications of SCOs, which can be easily found in microorganisms, in the pharmaceutical, cosmetic, and food industries. In addition, some aspects of 15- or 17-carbon-atom-long fatty acids were also pointed out. Furthermore, some challenges for heterotrophic single-cell oil synthesis and improvements in its extraction efficiency have also been concluded, which can further contribute to their broadened use in pharmacy, medicine, cosmetics, and food applications.

Analysis of the Role of Cosmetic Dermatology in Improving the Quality of Life of Patients with Vitiligo: Observational Study at Busan Hospital, South Korea

Introduction: Vitiligo is an autoimmune disease that causes skin depigmentation. This can have a significant impact on the patient's quality of life. Dermatological cosmetics can be used to cover depigmented areas and improve the patient's quality of life. Methods: This observational study was conducted on vitiligo patients treated at Busan Hospital, South Korea. Patients were given a questionnaire to assess their quality of life before and after using dermatology cosmetics. A total of 250 research subjects took part in this study. Data were analyzed using appropriate statistical tests. Results: The results showed that the use of dermatological cosmetics significantly improved the quality of life of vitiligo patients. Patients report improvements in self-satisfaction, self-image, and social interactions. Conclusion: Cosmetic dermatology is a safe and effective therapeutic option to improve the quality of life of vitiligo patients.

Spraying for the beauty: Pesticide use for visual appearance in apple production

AbstractPesticides are used to reduce yield losses and to enhance the visual quality of products. However, pesticide use raises concerns due to negative health and environmental effects, hence ambitious policy goals for their reduction have been established. Reducing pesticides which mainly focus on visual quality of products could be an efficient strategy to contribute to these goals, without reducing food production. However, the role of “cosmetic” pesticide use is so far not well documented and understood. Here, we quantify cosmetic pesticide use and the influence of supply chain characteristics on their use. We focus on table apple production, where the visual quality of products is a key aspect. Using a sample of 196 apple growers in Switzerland, we find that 23.5%–59.2% of growers use cosmetic pesticides for the apples’ visual appearance. Farms mainly marketing via intermediaries are 23.9‐29.6% more likely to spray cosmetic pesticides for visual purposes compared to farms mainly direct marketing. Our findings highlight the role of supply chains in farmer decision‐making, recommending a decrease in the focus on visual product quality, especially in retail environments, thus minimizing unnecessary and irreversible risks of pesticide exposure by farmers without compromising food security.

Valorization of Wine Lees: Assessment of Antioxidant, Antimicrobial and Enzyme Inhibitory Activity of Wine Lees Extract and Incorporation in Chitosan Films

Wine lees, as one of the main by-products of winery wastes, is considered a rich source of bioactive compounds such as polyphenols. Recovery of such bioactive compounds would amplify the valorization of winery by-products, as well as promote their use in cosmetics and health applications. Towards this aim, the objective of this work is the recovery of phenolic compounds from wine lees by ultrasound-assisted extraction. The effect of extraction time, and ethanol content on the extraction yield of total phenolics was investigated, while the phenolic profile of the extract was monitored by GC-MS. Under the optimized conditions, the total phenolic content was calculated at 302.6 mg gallic acid equivalents g− 1 dry extract; the dry extract was investigated for its biological activities, exhibiting excellent antioxidant and antimicrobial activity. Moreover, the extract was found to be a potent inhibitor of tyrosinase, elastase, collagenase, α-glucosidase, and α-amylase with IC50 values of 53.3, 83.5, 82.7, 19.0, and 31.3 µg mL− 1, respectively. Finally, the wine lees dry extract was incorporated into chitosan films, reinforcing the properties of the films, and providing them with excellent antioxidant activity. The results support that wine lees extract exhibits high antioxidant activity and can be used as a highly efficient inhibitor of enzymes with pharmaceutical and health interest. Moreover, the chitosan film enriched with wine lees extract is a promising material with high antioxidant potential and can lead to the development of novel food packaging films in the food industry.Graphical

Acne Vulgaris Triggering Factors in Females at Nangarhar University Teaching Hospital

Background: Acne vulgaris is a common disease in teenagers. It is a chronic inflammatory condition of the pilosebaceous units. Objective: To see the effect of different factors like age, skin type, diet, cosmetics, family history and pornographic material on acne. Methods: This case-control study was conducted in the Dermatology Department of Nangarhar University Teaching Hospital, Nangarhar from August 2021 to March 2021. The study consisted on a sample of 120 subjects including 60 cases of acne and 60 controls. The data was entered in a structured close-ended questionnaire. Univariate and multivariate logistic regression was used to see the effect of different factors on acne. Results: Age was below 20 years in 68 percent of patients and 38% of controls. Amongst patients 12% and amongst controls 7% were married. Logistic regression analysis showed that age (p = 0.001), odds ratio (0.288), Confidence interval (0.136–0.612) siblings history (p = 0.007), odds ratio (2.786), confidence interval (1.329–5.841), skin type (p = 0.000), dry skin (p = 0.173), odds ratio (0.449), confidence interval (0.142–1.422), oily skin (p = 0.002), odds ratio (3.925), confidence interval (1.684 9.146), cola drinks (p = 0.048), daily drinks (p = 0.023), odds ratio (2.975), confidence interval (1.159–7.636), cosmetic used (p = 0.004), odds ratio (4.219), confidence interval (1.577–11.285) and frequency of application of cosmetics (p = 0.010), odds ratio (3.509), confidence interval (1.347–9.1)had significant effect on acne. Conclusion: Acne is a more common disease in teenagers; age greater than twenty plays a protective role against acne. Carbonated drinks, positive sibling history, cosmetic treatment and frequent use of cosmetics have a significant relationship with acne. It is more common in oily skin than dry and normal skin

A chromosome-scale genome provides new insights into the typical carotenoid biosynthesis in the important red yeast Rhodotorula glutinis QYH-2023 with anti-inflammatory effects

Rhodotorula spp. has been studied as one powerful source for a novel cell factory with fast growth and its high added-value biomolecules. However, its inadequate genome and genomic annotation have hindered its widespread use in cosmetics and food industries. Rhodotorula glutinis QYH-2023, was isolated from rice rhizosphere soil, and the highest quality of the genome of the strain was obtained at chromosome level (18 chromosomes) than ever before in red yeast in this study. Comparative genomics analysis revealed that there are more key gene copies of carotenoids biosynthesis in R. glutinis QYH-2023 than other species of Rhodotorula spp. Integrated transcriptome and metabolome analysis revealed that lipids and carotenoids biosynthesis was significantly enriched during fermentation. Subsequent investigation revealed that the over-expression of the strain three genes related to carotenoids biosynthesis in Komagataella phaffii significantly promoted the carotenoid production. Furthermore, in vitro tests initially confirmed that the longer the fermentation period, the synthesized metabolites controlled by R. glutinis QYH-2023 genome had the stronger anti-inflammatory properties. All of the findings revealed a high-quality reference genome which highlight the potential of R. glutinis strains to be employed as chassis cells for biosynthesizing carotenoids and other active chemicals.

Evolving Advances in the Cosmetic use of Probiotics and Postbiotics: Health, Regulatory and Marketing Aspects.

Ongoing development in cosmetics is increasingly making use of probiotics, which are defined as "live microorganisms with health-enhancing properties mediated through ingestion or topical application to the host". The observation that several bacterial strains augment normal processes of healthy tissue maintenance, particularly for the skin, has opened up new avenues for the use of bacterial strains in cosmetics. A principal feature of such "cosmeceuticals" is an application of increasing insight into the biochemical nature of the skin's normal microbial flora, also called its microbiome. The opportunity of manipulating the skin microbiome to address various skin disorders has revealed novel routes for treatment. The skin microbiome manipulation approaches to address various skin disorders include skin microbiome transplantation, skin bacteriotherapy, and prebiotic stimulation. Research in this field has revealed that medical outcome-targeted manipulation of skin microbiome bacterial strain makeup may significantly increase skin health and appearance. Commercial availability of probiotic skincare products is rapidly expanding worldwide due to satisfactory laboratory results and public perception of probiotics as being intrinsically more wholesome than other bioactive substances, such as synthetics. Major outcomes of probiotic use include a significant reduction in skin wrinkling, acne and other conditions adversely affecting skin appearance and healthy function. Moreover, probiotics may additionally promote normal skin hydration, resulting in a vibrant and lustrous appearance. Nevertheless, significant technical challenges remain for the full optimization of probiotics in cosmetic products. This article summarizes the evolving nature of this field and explores current probiotic research initiatives, along with regulatory aspects and significant challenges in the manufacturing of cosmetics in the context of market expansion for these products.

The potential possibility of using food production waste to obtain products for medical and cosmetic use

The potential possibility of using food production waste to obtain products for medical and cosmetic use

In vitro to in vivo extrapolation to derive a metabolism factor for estimating the aggregate exposure to salicylic acid after dermal exposure of its esters

As part of the safety assessment of salicylate esters in cosmetics, we developed a metabolism factor based on in vitro to in vivo extrapolation (IVIVE) to provide a better estimation of the aggregate internal exposure to the common metabolite, salicylic acid. Optimal incubation conditions using human liver S9 were identified before measuring salicylic acid formation from 31 substances. Four control substances, not defined as salicylic esters but which could be mistaken as such due to their nomenclature, did not form salicylic acid. For the remaining substances, higher in vitro intrinsic clearance (CLint, in vitro) values generally correlated with lower LogP values. A “High-Throughput Pharmacokinetic” (HTPK) model was used to extrapolate CLint, in vitro values to human in vivo clearance and half-lives. The latter were used to calculate the percentage of substance metabolised to salicylic acid in 24 h in vivo following human exposure to the ester, i.e. the “metabolism factor”. The IVIVE model correctly reproduced the observed elimination rate of 3 substances using in silico or in vitro input parameters. For other substances, in silico only-based predictions generally resulted in lower metabolism factors than when in vitro values for plasma binding and liver S9 CLint, in vitro were used. Therefore, in vitro data input provides the more conservative metabolism factors compared to those derived using on in silico input. In conclusion, these results indicate that not all substances contribute equally (or at all) to the systemic exposure to salicylic acid. Therefore, we propose a realistic metabolism correction factor by which the potential contribution of salicylate esters to the aggregate consumer exposure to salicylic acid from cosmetic use can be estimated.

The potential possibility of using food production waste to obtain products for medical and cosmetic use

The potential possibility of using food production waste to obtain products for medical and cosmetic use

Concept of Cosmetology and its Historical Background in Unani Perspective

Unani physicians have paid great attention to the use of cosmetics since very ancient times. Around 4000 BC first archaeological evidence of cosmetics usage was found in ancient Egypt. The use of perfumes, oils, burning of aromatic incense, copper eye shadows, lamp black for eyes and dying of hairs red were in practice by ancient Egyptians. Unani literature is very rich in cosmeceutical formulations taking care of appearance and dealing with cosmetic diseases in humans. In Unani classical text like Kitab-ul-Mansoori, Al-Hawi-fil-Tib, Kamil-us-Sana, Al-Qanoon-fit-Tib, Zakheera-e-Khwarzam Shahi, the details of cosmetics are mentioned under the headings of Tazeeniyaat. This systematic review can be concluded that various cosmetics and cosmeceuticals prevailing in contemporary era may have been introduced or inspired by these physicians. There are several single drugs or compound formulations described in Unani classical text. Unani cosmetics can be a very good choice owing to their range, low cost and safety and can also be incorporated as an adjuvant in several contemporary preparation. There are several Unani cosmeceuticals are described in unani classical text like Solid Cosmeceutical (Ghaza, Ghaliya, Kajal), Semi-solid Cosmeceutical (Tila, Zimad, Ubtan) and Liquid cosmeceutical (Ghusool, Pashoya).
 Keywords: Unani Medicine, Cosmetics, Cosmeceuticals, Tazeeniyaat

A REVIEW ON CASIEN FROM VARIOUS MILK SAMPLES ITS USES AND IMPORTENCE

The milk proteins are the oldest and most widely consumed food proteins. There is currently a large interest in these substances, both in nutritional field and in technological application. Casein proteins are a family of proteins involved in the production of cheese and fermented milk. They are very important nitrogen compounds not only for the dairy products production, but they are also additives in medicine, and they have a technical use in cosmetics, paints and adhesives. : Milk is an important part of human life and supposed to be a nutritious food which contain about 80% proteins. Milk proteins consist of 80% casein (soluble protein), 2-8% lactose (milk fat) and remaining is whey (byproduct of cheese and casein manufacture). Casein is more important and contain almost all essential amino acids. The purpose of the present work was to estimate the amount of casein in different milk samples including natural milk (cow, buffalo, sheep and goat). Keywords: Milk powder, casein, Amino Acids, paint, cheese

A New Hyaluronic Emulgel of Hesperetin for Topical Application-An In Vitro Evaluation.

The present study aimed to formulate and characterize a hesperetin formulation to achieve adequate deposition and retention of hesperetin in the epidermis as a target for some cosmetic/dermatological actions. To derive the final emulgel, various formulations incorporating different proportions of Polysorbate 80 and hyaluronic acid underwent testing through a Box-Behnken experimental design. Nine formulations were created until the targeted emulgel properties were achieved. This systematic approach, following the principles of a design of experiment (DoE) methodology, adheres to a quality-by-design (QbD) paradigm, ensuring a robust and purposeful formulation and highlighting the commitment to a quality-driven design approach. The emulsions were developed using the phase inversion method, optimizing the emulgel with the incorporation of hyaluronic acid. Physically stable optimized emulgels were evaluated for their globule size, surface charge, viscosity, pH, electrical conductivity, and hesperetin content. These assays, along with the temperature swing test, were used to select the optimal formulation. It was characterized by a droplet size, d[4,3], of 4.02 μm, a Z-potential of -27.8 mV, an O/W sign, a pH of 5.2, and a creamy texture and proved to be stable for at least 2 months at room temperature. Additionally, in vitro release kinetics from the selected emulgel exhibited a sustained release profile of hesperetin. Skin assays revealed adequate retention of hesperetin in the human epidermis with minimum permeation. Altogether, these results corroborate the promising future of the proposed emulgel in cosmetic or dermatological use on healthy or diseased skin.

Mechanistic Insights into the Multiple Functions of Niacinamide: Therapeutic Implications and Cosmeceutical Applications in Functional Skincare Products.

Niacinamide (or nicotinamide) is a small-molecule hydrosoluble vitamin with essential metabolic functions in mammalian cells. Niacinamide has become a key functional ingredient in diverse skincare products and cosmetics. This vitamin plays a pivotal role in NAD+ synthesis, notably contributing to redox reactions and energy production in cutaneous cells. Via diversified biochemical mechanisms, niacinamide is also known to influence human DNA repair and cellular stress responses. Based on decades of safe use in cosmetics, niacinamide recently gained widespread popularity as an active ingredient which aligns with the "Kligman standards" in skincare. From a therapeutic standpoint, the intrinsic properties of niacinamide may be applied to managing acne vulgaris, melasma, and psoriasis. From a cosmeceutical standpoint, niacinamide has been widely leveraged as a multipurpose antiaging ingredient. Therein, it was shown to significantly reduce cutaneous oxidative stress, inflammation, and pigmentation. Overall, through multimodal mechanisms, niacinamide may be considered to partially prevent and/or reverse several biophysical changes associated with skin aging. The present narrative review provides multifactorial insights into the mechanisms of niacinamide's therapeutic and cosmeceutical functions. The ingredient's evolving role in skincare was critically appraised, with a strong focus on the biochemical mechanisms at play. Finally, novel indications and potential applications of niacinamide in dermal fillers and alternative injectable formulations were prospectively explored.

Physico-chemical and nutritional characteristics of kernels oil from two mangoes varieties (Amélie and Kent) harvested at Orodara in Burkina Faso

The mango tree (Mangifera indica) plays an important role for Burkina Faso people. This importance is due to its consumption, its pharmaceutical properties and its shade. However, all this importance is limited to the fleshy parts, leaves, bark and roots, whereas the mango tree's kernels are full of potential that can be exploited, but remain little known. Two mango varieties (Amélie and Kent) were sampled at the Bobo-Dioulasso fruit and vegetable market from Orodara. The fat content and physico-chemical parameters of the mangoes were determined using conventional methods. The results obtained show that the oil's biochemical composition gives it its full importance. This oil meets most of the standards set by the Codex Alimentarius for virgin oils. Mango kernels do indeed contain a fat content of between 3.039 and 6.486%. For moisture content, we found 56.095% and 56.070%, which already exceeds half the kernel's constitutional weight. In terms of chemical parameters, the highest acid value was 2.664 mg KOH/g, compared with 4.0 mg KOH/g as the maximum limit of the Codex Alimentarius standard. The peroxide value was equal to 9.523 mEqO₂/kg against 10 mEqO₂/kg as the maximum limit of the standard. We have a good concentration of saturated fatty acids at least 47% for the lowest concentration and 24% of unsaturated fatty acids for the lowest concentration. In view of these results, mango kernels should be valorized in order to add value to mango waste, with a view to use in cosmetics or medicine, as well as to depollute the environment.

Questionnaire-Based Study of 392 Women in Abbottabad, Pakistan, to Evaluate the Types of Cosmetic Products Purchased Between December 2018 and March 2019 and Their Associated Adverse Events.

BACKGROUND Cosmetics are applied topically to enhance appearance and are commonly used by women of all ages. Cosmetics contain many chemical agents, but the incidence of adverse reactions is low, possibly due to underreporting. This questionnaire-based study included 392 women to evaluate information on the types of cosmetics purchased between December 2018 and March 2019, their use by the women surveyed, and their associated adverse events. MATERIAL AND METHODS A cross-sectional study was conducted among 392 women in Abbottabad, Pakistan, using a pre-structured and validated questionnaire to evaluate information on the types of cosmetics, their use, and their associated adverse events. Part 1 of the study collected information about demographics. Part 2 contained a total of 11 items, and collected the frequency of use of cosmetic on skin and hair care products. Part 3 consisted of 4 items and collected information about problems encountered due to the use of cosmetics. RESULTS In the winter season, 47.7% (n=187) of women preferred chemical-based cosmetic products, while 30.9% (n=121) preferred Ayurvedic products. Among commonly used cosmetic products, 26.9% (n=106) of women used foundations. The most frequently used skin care product was face wash 39.5% (n=155). The most prevalent adverse events related to cosmetics were pimples (19.9%, n=78), redness (17.6%, n=69), and eye discomfort (15.8%, n=62). Furthermore, 51.3% (n=201) strongly agreed that cosmetics aid in getting a whiter complexion. CONCLUSIONS The survey concluded that most women preferred cosmetics with a chemical base, which are associated with rashes, redness, and acne. It is important to encourage cosmetovigilance and awareness campaigns among cosmetic product sellers and users.

피부노화 인식이 이너뷰티 구매 행동의도에 미치는 영향 연구

There has been a rising demand for rational and professional skincare habits to slow down or prevent skin aging. Under these circumstances, inner-beauty products have recently played a major trend. This study attempted to investigate the perception of skin aging and inner-beauty product purchase behavior intention-related factors against adult women and analyze their correlations, and the results found the followings: First, the perception of skin aging had a statistically significant influence on inner-beauty purchase behavior intention. Second, the perception of skin aging revealed a statistically significant effect on skincare behavior. Third, skincare behavior affected inner-beauty purchase behavior intention with statistical significance. Fourth, skincare behavior between perception of skin aging and inner-beauty purchase behavior intention revealed a statistically significant influence as a mediator variable. The above results confirm that perception of skin aging and skincare behavior such as use of cosmetics have an influence on inner-beauty purchase behavior intention. It is anticipated that the study results would be available as basic data for developing inner-beauty products and marketing strategies.

Formulation And Evolution Of Microemulgel Contain Terbinafine Hcl

Aim of this experiment is to prepare miroemulgel containing terbinafine hcl API and it evaluation tests. API is terbinafine hcl and other polymers like tween 20, span80 surfactants are used and other liquid paraffin, water used. This study shows that microemulgel prepared and good release study both batches show good results. In this all oil and surfaces are mix in carpool base and prepare gel good gel appearance form. The Microemulgel for skin conditions & Cosmetic use have different desirable properties such as good appearance, being thixotropic ratio, easily spreadable, Non-staining, and emollient, without form any harm, clear, transparent & elegant appearance, & these Microemulgel based formulations increase the skin deposition of API, thereby ultimately enhancing its therapeutic activity. Terbinafine is a broad-spectrum anti-antifungal medication.