Use Of Betadine Research Articles

Connaissances et pratiques des étapes préalables à la stérilisation des dispositifs médicaux thermorésistants : étude au centre hospitalo-universitaire Sahloul, Sousse-Tunisie – 2022

The standard process of central sterilization is crucial for the optimal functioning of the operating room. The outcome of this process is closely linked to the steps preceding the steps prior to the sterilization step itself. These steps include pre-disinfection carried out in the operating rooms and other stages, namely washing, drying and packaging, which must be performed in the central sterilization unit. In this context, this study aimed to describe the knowledge of the staff in the operating rooms and the central sterilization unit at Sahloul University Hospital in Sousse (Tunisia) in 2022, regarding the steps prior to the sterilization of reusable thermoresistant medical devices and to describe their practices in terms of compliance with these steps. A descriptive study was conducted from January 2022to June 2022with the aforementioned staff, using a self-administered questionnaire to assess their knowledge of the pre-sterilization steps and a direct observation audit of their practices with regard to these steps. Both measurement instruments were pre-tested. Out of 102self-administered questionnaires (knowledge assessment) distributed to the staff concerned, only 80were returned and correctly filled out, giving a response rate of 78.4%. Participants' responses regarding the order of steps prior to the sterilization were incorrect in 64% of cases. With regard to the evaluation of professional practices, 224observations were made in the study area (practice audit). In 82% of these observations, the pre-disinfection step was confused with the washing step. The use of Betadine brushes and scrubbing pads for device washing was noted in 89.3%, along with the absence of swabbing of the canals and hollow parts in 9.4% of cases and the absence of drying of the canals with compressed air. Mastery of the steps prior to sterilisation of reusable thermoresistant medical devices was insufficient in our institution, suggesting the importance of reinforcing the implementation of the procedure through a continuous training program followed by action plans.

The use of betadine for the treatment of dysbiotic and fungal diseases of the vagina in pregnant women

Betadine can be recommended for the treatment of vaginitis in pregnant women in order to improve the microbiocenosis before childbirth and for the prevention of postpartum infectious complications.

Effect of Betadine on Lymphocele Formation During Kidney Transplantation Surgery

Background: Lymphocele formation post-renal transplantation surgery can cause various complications such as pelvic pain, frequent urination, hydronephrosis, deep vein thrombosis, etc. It is, therefore, necessary to prevent and treat lymphocele. Objectives: This study aimed to evaluate the effect of rinsing the surgical site with betadine (povidone-iodine 2%) on the prevention of lymphocele formation during kidney transplantation surgery. Methods: This case-control study was conducted at Tehran University of Medical Sciences in 2019. The study population consisted of 60 kidney transplant patients referred to Sina Hospital, located in Tehran, who were randomized into two groups of study and control by simple randomization using a computer-generated random list. The surgical site of one group (control group: 30 patients) was washed with povidone-iodine 2%, but this operation was not performed for the patients of the other group (control group: 30 patients). One month after the surgery, patients were monitored for lymphocele via ultrasound, and their sera’s creatinine level was measured to assess renal function. For all statistical interpretations, P < 0.05 value was accepted as being significant. Statistical analyses were performed with statistical software package SPSS version 23. Results: Results: The mean serum creatinine level of patients in the case group was 2.50 ± 1.78, and in the control group was 2.31 ± 1.89. Ultrasound performed one-month post-renal transplant showed the presence of lymphocele in 17 patients out of the total 30 in the study group, while the control group had only 12. Conclusions: It seems that the use of betadine during kidney transplant surgery does not prevent the formation of lymphocele after the surgery

Intraoperative Use of Betadine Irrigation is Associated With a 9-Fold Increased Likelihood of Penile Prosthesis Infection: Results From a Retrospective Case-Control Study.

IntroductionInfection remains a persistent complication of penile prosthesis (PP) surgery. Despite popularity of Mulcahy’s PP washout protocol, Betadine has known tissue toxicity.AimWe evaluated PP infection rate based on the type of intraoperative irrigation used, ½ strength Betadine vs vancomycin/gentamicin.MethodsWe reviewed a prospective database of men undergoing primary, revision, and salvage PPs. No other changes to operative or perioperative techniques occurred after the change in irrigation solution. Univariate and logistic regression analyses were used to evaluate differences in infection rate with use of Betadine vs vancomycin/gentamicin irrigation. Potential confounders were reviewed.Main Outcome MeasureThe primary outcome was rate of PP infection before and after change of intraoperative irrigation.ResultsFrom 2014 to 2018, 217 patients underwent PP placement at our institution by a single surgeon; of whom, 21 (9.7%) experienced an infection (primary = 10 [7.1%], revision = 11 [17.19%], salvage = 0 [0%]). Overall, 152 (70%) received irrigation with Betadine and 65 (30%) with Vancomycin/Gentamicin. Univariate analysis demonstrated significantly increased infection rates with Betadine irrigation (odds ratio [OR]: 4.64, P = .006) and with revision surgery (OR: 2.68, P = .02). Significance of increased infection rate with Betadine was maintained (OR: 9.3; P = .025) after controlling for age, body mass index, Charlson comorbidity index, smoking, diabetes, primary vs revision/salvage, prior penile surgery, use of ectopic reservoir, and adjunctive glanulopexy.ConclusionsChanging from intraoperative Betadine to vancomycin/gentamicin solution dramatically reduced infection rates among men undergoing PP placement in both primary and revision cases. We hypothesize that differences in infection rate may relate to the relative toxicity or non-sterile nature of Betadine.Manka MG, Yang D, Andrews J, et al. Intraoperative Use of Betadine Irrigation is Associated With a 9-Fold Increased Likelihood of Penile Prosthesis Infection: Results From a Retrospective Case-Control Study. Sex Med 2020;8:422–427.

MP27-18 INTRAOPERATIVE USE OF BETADINE IRRIGATION IS ASSOCIATED WITH A 9-FOLD INCREASE OF PENILE PROSTHESIS INFECTION

INTRODUCTION AND OBJECTIVES:Infection remains a persistent complication of inflatable penile prosthesis (IPP) surgery. Despite popularity of the Mulcahy IPP washout protocol, Betadine has known tissue toxicity. We evaluated IPP infection rate based on the type of intraoperative irrigation utilized, Betadine (10%) versus Vancomycin / Gentamicin, and other factors which may affect infection rate.METHODS:We reviewed a consecutive series from a detailed, prospective database of men undergoing primary, revision, and salvage penile prostheses at our institution. The primary outcome was rate of IPP infection prior to and following change of intra-operative irrigation. No other changes to operative or perioperative techniques occurred following the change in irrigation solution. Univariate and regression analyses were used to evaluate differences in infection rate with use of Betadine versus Vancomycin/Gentamicin irrigation. Multiple potential confounders were reviewed including patient demographics, comorbiditie...

299 Intra-operative Use of Betadine Is Associated with an Increased Rate of Penile Prosthesis Infections

Inflatable penile prostheses (IPP) remain the gold standard for medically refractory erectile dysfunction (ED). Despite high overall success and satisfaction rates, infections remain a persistent and significant complication. In our clinical practice, we continued to experience high rates of infections despite use of a no-touch technique, voluminous irrigation, antibiotic-impregnated devices, post-op antibiotics, and multiple other intra-operative considerations. However, after switching from Betadine irrigation to Vancomycin / Gentamicin, we anecdotally noted an immediate reduction in infections, which prompted the current analysis. To compare the rate of IPP infections based on the type of intra-operative irrigation utilized: Betadine versus Vancomycin / Gentamicin. We reviewed a detailed, prospective database of men undergoing primary, revision, and salvage penile prostheses at our institution. The primary outcome was rate of penile prosthesis infection prior to and following change of intra-operative irrigation. It is notable that no other changes to operative or perioperative techniques occurred following the change in irrigation solution. Multiple variables were reviewed as potential confounders including patient demographics, comorbidities, type of surgery (primary, revision, salvage), number of prior prostheses, and adjunctive techniques. Univariate analysis was performed to evaluate for differences in rate of infection with use of Betadine versus Vancomycin / Gentamicin irrigation. Regression analysis was performed to control for variables noted to significantly impact infection rate.

Black Eschar on a 4-day-old Preterm Infant

A 4-day-old female neonate presented with a black necrotic lesion with circumferential ulceration and erythema located to the left of the umbilicus. ### Prenatal and Birth Histories ### Presentation The infant was admitted to the NICU. An umbilical venous catheter (UVC) was inserted with the use of betadine as the antimicrobial skin preparation and a thin hydrocolloid dressing (DuoDERM®, ConvaTec, Bridgewater, NJ) as a protective skin barrier to secure the UVC. The hydrocolloid dressing was located just left of the umbilicus and placed on intact abdominal skin. The infant was noted to have asymptomatic thrombocytopenia (platelet count 73,000/μL [73×109/L]) and neutropenia (absolute neutrophil count 700/μL [0.70×109/L]), which were attributed to maternal preeclampsia. The infant received 1 dose of granulocyte colony-stimulating factor (G-CSF, 10 μg/kg, subcutaneously) at 2 days of age. Prophylactic antibiotics were not indicated at the time of birth because there were no concerns for infection. The infant underwent extubation to receive nasal noninvasive ventilation within 24 hours of birth. …

Betadine and Breast Implants.

In the fourth quarter of 2017, the US FDA reviewed and approved a request by one of the breast implant manufacturers for a change in the Directions for Use (DFU) that removed warnings regarding the use of Betadine (povidone-iodine [PI] 10% solution, 1% available iodine [Purdue Frederick Company, Stamford, CT], also available in generic formulations [Aplicare, Inc., Meriden, CT]). Previously, in 2000, there were concerns by the FDA that PI would degrade the silicone elastomer shell. This change in the DFU represents an important advance that will benefit patients through the permitted use of PI to reduce the risk of bacterial contamination of implant surfaces. What was formerly an off-label practice can be openly practiced by plastic surgeons as an anti-infective and biofilm-mitigation strategy. PI has an ideal spectrum effect for gram-positive and gram-negative organisms. Gram-positive organisms have been linked to capsular contracture and gram-negative Ralstonia picketti to breast implant-associated anaplastic large cell lymphoma (BIA-ALCL). R picketti is resistant to aminoglycoside antibiotics, but it is susceptible to at least a 50% solution of PI. We believe that the strategy of antisepsis and biofilm mitigation is an integral part of a contemporary approach for breast augmentation. This is beneficial regarding reduction of the risk of surgical infection, capsular contracture, and BIA-ALCL. Outcome data so far indicate that antibiotics/anti-infectives seem to reduce the incidence of these adverse events that lead to reoperation and increased costs. It behooves plastic surgeons to take all actionable steps that enhance the quality of breast implant outcomes and reduce the rate of reoperation.

Comparison of the recovery rate of otomycosis using betadine and clotrimazole topical treatment.

IntroductionOtomycosis is a common diseases that can be associated with many complications including involvement of the inner ear and mortality in rare cases. Management of otomycosis can be challenging, and requires a close follow-up. Treatment options for otomycosis include local debridement, local and systemic antifungal agents and utilization of topical antiseptics.ObjectiveThis study was designed to compare the recovery rate of otomycosis using two therapeutic methods; topical betadine (Povidone-iodine) and clotrimazole.MethodsIn this single-blind clinical trial, 204 patients with otomycosis were selected using a non-probability convenient sampling method and were randomly assigned to two treatment groups of topical betadine and clotrimazole (102 patients in each group). Response to treatment was assessed at 4, 10 and 20 days after treatment. Data were analyzed using the independent t-test, Chi-Square and Fisher exact test in SPSS v.18 software, at a significance level of p < 0.05.ResultsThe results showed that out of 204 patients with otomycosis, fungi type isolated included Aspergillus in 151 cases (74%), and Candida albicans in 53 patients (26%). On the fourth day after treatment, 13 patients (13.1%) in the group treated with betadine and 10 patients (9.8%) in the group treated with clotrimazole showed a good clinical response to treatment (p = 0.75). A good response to treatment was reported for 44 (43.1%) and 47 patients (46.1%) on the tenth day after the treatment (p = 0.85); and 70 (68.6%) and 68 patients (67.6%) on the twentieth day after treatment (p = 0.46) in the groups treated with betadine and clotrimazole, respectively. The response to treatment was thus not significantly different in the two groups.ConclusionIn the present study the efficacy of betadine and clotrimazole was the same for the treatment of otomycosis. The result of this study supports the use of betadine as an effective antifungal in otomycosis treatment, helping to avoid the emergence of resistant organisms.

Does Leaving the Biopsy Needle in Povidone-Iodine Solution Reduce Infective Complications after Biopsy?

Aim. The aim of this study is to evaluate whether leaving the biopsy needle used during prostate needle biopsy in 10% povidone-iodine (betadine) solution affects the infectious complications forming after biopsy. Material and Method. This study retrospectively evaluated the data of 176 patients with prostate biopsy performed between December 2012 and April 2014. Patients in Group 1 (n = 89) were given ofloxacin as a prophylactic antibiotic before biopsy. Patients in Group 2 (n = 87) had the biopsy needle left in povidone-iodine solution for 1 minute before each use, in addition to antibiotic prophylaxis. The two groups were compared in terms of infective complications developing after biopsy. Results were analyzed using the Mann–Whitney U test and Fisher's exact test. Results. The distribution of infective complications after biopsy according to group was as follows. Group 1, not using betadine, had 15.7% fever, 13.5% hospital stay, 12.4% urinary retention, 10.1% prostatitis, and 5.6% sepsis. The distribution of the same complications in Group 2 using betadine was identified as 5.7% fever, 4.6% hospital stay, 3.4% urinary retention, 2.3% prostatitis, and 0% sepsis. The use of betadine was found to significantly reduce the infectious complications after biopsy compared to the control group (p < 0.05). Conclusion. At the end of this study leaving the prostate needle in povidone-iodine solution before each use during prostate biopsy was found to reduce the infective complications and hospital stay after biopsy.

Betadine and Breast Implants

In the spring of 2000, the US Food and Drug Administration (FDA) issued a ban on the use of Betadine (Purdue Frederick, Stamford, Connecticut) with breast implants due to concern about an adverse effect on shell integrity that could lead to implant deflation or rupture. The ban was enacted primarily on the basis of 2 studies, the first of which was presented to the FDA by Mentor Corporation (Santa Barbara, California). This study tested Mentor saline implants with long-term intraluminal Betadine fill, and subsequent valve patch delamination was reported.1 This was the first published instance of Betadine being used intraluminally rather than as pocket irrigation, which may have contributed to negative results. The second study evaluated the effect of Betadine on silicone elastomer. Changes in elastomer strength and color were demonstrated, but this was the result of soaking the fill tube in Betadine and not the implant shell, which is manufactured differently.2 At that time, the FDA advisory panel did not recommend a prohibition on the use of Betadine with breast implants, however the FDA chairman went against the panel's recommendation and the prohibition was put in place.3 In my own practice, I utilize Betadine irrigation because it offers ease of use, minimized medication error potential, decreased allergic risk (for patients who are allergic to Betadine, I use Adams's triple antibiotic irrigation4), and cost-effectiveness. Furthermore, studies—including my own5 and those of Adams et al,4 Burkhardt and Eades,6 and many others—have shown not only no deleterious effect of Betadine on breast implants but also a significant decrease in the incidence of capsular contracture (CC). In fact, CC rates can be reduced to 1% or less with the use of Betadine,4–6 a significant finding considering that CC can result in significant patient …

Evaluation of Effect and Comparision of Superoxidised Solution (Oxum) V/S Povidone Iodine (Betadine): Points to Ponder

We read the article “Evaluation of Effect and Comparison of Superoxidised Solution (Oxum) v/s Povidone Iodine (Betadine)” [1] with interest. We would like to seek a few clarifications from the authors regarding the methodology and the results and would appreciate a declaration of any conflict of interest. In the abstract, the authors mention “We retrospectively analysed the records of 200 patients with different types of wounds who attended Department of Surgery” which metamorphoses in the observation section to “The present study comprising of 200 patients prospectively randomized into two groups of 100 patients each was conducted.” No mention is made about the method of randomization into the two groups, whether any attempts were made to blind the observers, or the statistical tests employed to analyze the results, and what P value was considered significant. The study includes wounds ranging from acute ulcers to intraperitoneal collections, and three of the eight graphs show impressive results of percentage decrease in wound size, periwound erythema, and pus discharge in acute abscesses. Three graphs deal with the reduction in wound size in diabetic foot, venous ulcers, and Fournier’s gangrene, and the last two graphs show the percent increase in epithelization and granulation in burns and fistula-in-ano. However, no mention is made of the absolute number of patients in these subgroups. This makes it difficult to appreciate the differences between the treatment groups, if any. Furthermore, we are unable to understand how Betadine and Oxum were employed in fistula-in-ano or cellulitis. What was the concentration and method of use of Betadine for the lavage of the peritoneal cavity and whether such use is supported by literature? The authors have mentioned “A standard grading in terms of percentage decrease in wound size, periwound edema/erythema, pus discharge and percentage increase in granulation.” There are a large number of wound grading systems described in the literature; for example, Wagner’s classification for diabetic foot ulcers, and we were unable to appreciate the use of an indigenous non-validated grading system chosen by the authors. An element of bias is also introduced by the use of debridement on an “as and when needed” basis and can influence the rate of healing between the two groups.

Episiotomy pain relief: Use of Lavender oil essence in primiparous Iranian women

Introduction Post-episiotomy discomfort and its consequences can affect maternal quality of life and mental health as well as the mother and baby relationship. Complementary medicine is increasingly used and Lavender oil is frequently prescribed due to its antiseptic and healing properties. Method This clinical trial involved 60 qualified primiparous women admitted for labor in Kamali Hospital in Karaj, Iran. They were randomly categorized into two groups: case (using Lavender oil) and control (usual hospital protocol). Participants pain and discomfort were recorded using a Visual Analogue Scale (VAS) and a Redness, Edema, Ecchymosis, Discharge Scale (REEDA). Pain was evaluated at 4 h, 12 h and 5 days following episiotomy. Collected data was analyzed in SPSS 14 using an independent t-test and chi-square. Results There was a statistical difference in pain intensity scores between the 2 groups after 4 h ( p = 0.002, and 5 days ( p = 0.000) after episiotomy. However, differences in pain intensity between the two groups, at 12 h post-surgery, were not significant ( p = 0.066). The REEDA score was significantly lower in the experimental group (Lavender oil group) 5 days after episiotomy ( p = 0.000). Conclusion According to these findings, use of Lavender oil essence can be effective in reducing perineal discomfort following episiotomy. It is suggested that Lavender oil essence may be preferably to the use of Betadine for episiotomy wound care.

The Role of Betadine Irrigation in Breast Augmentation

In the spring of 2000, the U.S. Food and Drug Administration issued a ban on the use of Betadine (povidone-iodine; Purdue Frederick, Stamford, Conn.) in association with saline breast implants, because data seemed to indicate a higher rate of implant deflation in association with Betadine. Betadine has been used for many years because studies have shown a decrease in the rate of capsular contracture when the breast pocket is irrigated with Betadine at the time of augmentation. Breast augmentations performed from January of 1998 through September of 2005 were reviewed. The review included an analysis of how Betadine was used at the time of each augmentation, along with the incidences of implant deflation and capsular contracture. Findings were compared with data used by the Food and Drug Administration in their breast implant literature. The deflation rate was significantly lower than that reported in the data from the Food and Drug Administration and the Institute of Medicine (0.24 percent versus 7 to 10 percent). The capsular contracture rate was lower than that in the Food and Drug Administration data, especially when Betadine was used as indicated in the final phase (0.5 to 2.2 percent versus 10 to 11 percent). This article confirms other studies reporting that the use of Betadine has no effect on the rate of deflation of a saline breast implant. It also shows that the incidence of capsular contracture is significantly decreased with the proper use of Betadine.

Optimizing breast-pocket irrigation: the post-betadine era.

The practice of breast-pocket irrigation with various antibiotic solutions is supported by good literature and extensive clinical practice among most plastic surgeons. Unfortunately, recent restrictions on the use of Betadine (povidone-iodine) for breast-pocket irrigation have left many plastic surg

Protein-bound iodine and T4 tests after vaginal application of povidone-iodine

Serum PBI and T4 determinations were done on ten patients before and one day, one week, and one month after the use of povidone-iodine∗∗Betadine, Purdue-Frederick Company, Yonkers, New York. as a vaginal preoperative preparation. A significant rise was found at one day in the PBI but no significant change was found for the most part at one week and one month. The T4 levels were not significantly altered the first week after the use of Betadine.