Use In Solid-phase Synthesis Research Articles

Rigid polar composite supports for use in solid phase synthesis

AbstractA number of particulate polyethylene and polypropylene based matrices have been γ ‐radiation grafted with poly(acryloylsarcosine methyl ester). The resulting composite materials have physicochemical properties attractive for use in continuous solid phase synthesis. Three macroporous polystyrene resins have also been impregnated with a secondary polyamide network using thermal initiation. All of these retain their rigid spherical structure and the composite properties again make them good candidates for use under pressure. One of these has been used in a preliminary solid phase experiment and two successive amino acid residues coupled with ∼100% yield.

Side chain protected Nα-fluorenylmethoxycarbonylamino-acids for solid phase peptide synthesis. Nα-Fluorenylmethoxycarbonyl-NG-4-methoxy-2,3,6-trimethylbenzenesulphonyl-L-arginine

The preparation and use in solid phase synthesis of Nα-fluorenylmethoxycarbonyl-NG-4-methoxy-2,3,6-trimethylbenzenesulphonyl-L-arginine is described.