The article considers the objective necessity of state regulation and support of innovative agroindustrial business in the conditions of a market environment, integration, globalization of economic processes and intensification of competition in the domestic and foreign markets. A retrospective analysis of the support of business entities in the regions of Ukraine has been carried out. A significant variability of the level of its support in the dynamics and regions has been revealed. It showed the absence of a proper system of regulation and business support. We have explored the leading global experience of effective support; an overall assessment of total agricultural support (TSE); Producer Support (PSE) and Consumers (GSSE) according to the Organization for Economic Cooperation and Development (OECD) methodology. The advantages, prospects and drawbacks of the current key agricultural support models in the context of the use of agricultural practices in Ukraine are considered in this research.