US Females Research Articles

Glypican-1 exosomes: do they initiate a new era for early pancreatic cancer diagnosis?

According to the National and Comprehensive Cancer Network (NCCN), currently pancreatic cancer (PC) is the fourth leading cause of cancer-related death among US males and females (1). Peak incidence of PC is around the 7 th –8 th decade of life, and it has been linked to few predisposing factors including: cigarette smoking, obesity, red meat and heavy alcohol consumption along with chronic pancreatitis (1).

Use of population-referenced total activity counts percentiles to assess and classify physical activity of population groups

ObjectivesPopulation-referenced total activity counts per day (TAC/d) percentiles provide public health practitioners a standardized measure of physical activity (PA) volume obtained from an accelerometer that can be compared across populations. The purpose of this study was to describe the application of TAC/d population-referenced percentiles to characterize the PA levels of population groups relative to US estimates. MethodsA total of 679 adults participating in the 2011 NYC Physical Activity Transit survey wore an ActiGraph accelerometer on their hip for seven consecutive days. Accelerometer-derived TAC/d was classified into age- and gender-specific quartiles of US population-referenced TAC/d to compare differences in the distributions by borough (N=5). ResultsMales in Brooklyn, Manhattan, and Staten Island had significantly greater TAC/d than US males. Females in Brooklyn and Queens had significantly greater levels of TAC/d compared to US females. The proportion of males in each population-referenced TAC/d quartile varied significantly by borough (χ2(12)=2.63, p=0.002), with disproportionately more men in Manhattan and the Bronx found to be in the highest and lowest US population-referenced TAC/d quartiles, respectively. For females, there was no significant difference in US population-reference TAC/d quartile by borough (χ2(12)=1.09, p=0.36). ConclusionsThese results demonstrate the utility of population-referenced TAC/d percentiles in public health monitoring and surveillance. These findings also provide insights into the PA levels of NYC residents relative to the broader US population, which can be used to guide health promotion efforts.

The secular decline in general intelligence from decreasing developmental stability: Theoretical and empirical considerations

The g-loss predicted based on genetic selection is smaller than that observed across various ratio-scale measures of cognitive ability. The difference may result in part from the accumulation of deleterious mutations across generations, reducing g via their effects on developmental stability/fitness. Previously published secular trend data on a developmental stability measure, craniofacial fluctuating asymmetry (FA) size, for white US males and females covering 14 and 15 decades respectively, are re-analysed. When the secular increases in FA size are rescaled as declines in latent developmental stability, and multiplied by the validity and reliability adjusted developmental stability-g correlation, g-losses of −.16 points per decade are predicted for the males, females and the combined sample. Predicted fitness losses due to mutation accumulation may account for 30% of the generational decline (−.05 points per decade), indicating only a small role for mutations in secular g-loss. The remaining 70% (−.11 points per decade) may result from developmental stability disrupting environmental change, such as increased exposure to pollutants. Adding these to the g-loss due to selection (re-estimated at −.54 points per decade) yields a combined decadal loss of −.70 points. Additional adjustments for replacement migration and the generation length-g interaction yield a larger magnitude decadal g-loss of −1.25 points.

Evaluation of the risk of venous thromboembolism after quadrivalent human papillomavirus vaccination among US females

After the Food and Drug Administration (FDA) licensed quadrivalent human papillomavirus vaccine (HPV4) in 2006, reports suggesting a possible association with venous thromboembolism (VTE) emerged from the Vaccine Adverse Event Reporting System and the Vaccine Safety Datalink. Our objective was to determine whether HPV4 increased VTE risk.The subjects were 9−26-year-old female members of five data partners in the FDA's Mini-Sentinel pilot project receiving HPV4 during 2006−2013. The outcome was radiologically confirmed first-ever VTE among potential cases identified by diagnosis codes in administrative data during Days 1−77 after HPV4 vaccination. With a self-controlled risk interval design, we compared counts of first-ever VTE in risk intervals (Days 1−28 and Days 1−7 post-vaccination) and control intervals (Days 36−56 for Dose 1 and Days 36−63 for Doses 2 and 3). Combined hormonal contraceptive use was treated as a potential confounder. The main analyses were: (1) unadjusted for time-varying VTE risk from contraceptive use, (2) unadjusted but restricted to cases without such time-varying risk, and (3) adjusted by incorporating the modeled risk of VTE by week of contraceptive use in the analysis.Of 279 potential VTE cases identified following 1,423,399 HPV4 doses administered, 225 had obtainable charts, and 53 were confirmed first-ever VTE. All 30 with onsets in risk or control intervals had known risk factors for VTE. VTE risk was not elevated in the first 7 or 28 days following any dose of HPV in any analysis (e.g. relative risk estimate (95% CI) from both unrestricted analyses, for all-doses, 28-day risk interval: 0.7 (0.3−1.4)). Temporal scan statistics found no clustering of VTE onsets after any dose.Thus, we found no evidence of an increased risk of VTE associated with HPV4 among 9−26-year-old females. A particular strength of this evaluation was its control for both time-invariant and contraceptive-related time-varying potential confounding.

Differentiation of ovarian development and the evolution of fecundity in rapidly diverging exotic beetle populations.

Fecundity is a fundamental determinant of fitness, yet the proximate developmental and physiological mechanisms that enable its often rapid evolution in natural populations are poorly understood. Here, we investigated two populations of the dung beetle Onthophagus taurus that were established in exotic ranges in the early 1970s. These populations are subject to drastically different levels of resource competition in the field, and have diverged dramatically in female fecundity. Specifically, Western Australian O. taurus experience high levels of resource competition, and exhibit greatly elevated reproductive output compared to beetles from the Eastern US, where resource competition is minimal and female fecundity is low. We compared patterns of ovarian maturation, relative investment into and timing of egg production, and potential trade-offs between ovarian investment and the duration of larval development and adult body size between populations representative of both exotic ranges. We found that the rapid divergence in fecundity between exotic populations is associated with striking differences in several aspects of ovarian development: (1) Western Australian females exhibit accelerated ovarian development, (2) produce more eggs, (3) bigger eggs, and (4) start laying eggs earlier compared to their Eastern US counterparts. At the same time, divergence in ovarian maturation patterns occurred alongside changes in (5) larval developmental time, and (6) adult body size, and (7) mass. Western Australian females take longer to complete larval development and, surprisingly, emerge into smaller yet heavier adults than size-matched Eastern US females. We discuss our results in the context of the evolutionary developmental biology of fecundity in exotic populations.

Acne treatment patterns, expectations, and satisfaction among adult females of different races/ethnicities.

BackgroundLimited data are available on acne treatment patterns, expectations, and satisfaction in the adult female subpopulation, particularly among different racial and ethnic groups.ObjectiveDescribe acne treatment patterns and expectations in adult females of different racial/ethnic groups and analyze and explore their potential effects on medication compliance and treatment satisfaction.MethodsA cross-sectional, Web-based survey was administered to US females (25–45 years) with facial acne (≥25 visible lesions). Data collected included sociodemographics, self-reported clinical characteristics, acne treatment use, and treatment expectations and satisfaction.ResultsThree hundred twelve subjects completed the survey (mean age, 35.3±5.9 years), comprising black (30.8%), Hispanic (17.6%), Asian/other (17.3%), and white (34.3%). More than half of the subjects in each racial group recently used an acne treatment or procedure (black, 63.5%; Hispanic, 54.5%; Asian/other, 66.7%; white, 66.4%). Treatment use was predominantly over-the-counter (OTC) (47.4%) versus prescription medications (16.6%). OTC use was highest in white subjects (black, 42.7%; Hispanic, 34.5%; Asian/other, 44.4%; white, 59.8%; P<0.05). The most frequently used OTC treatments in all racial/ethnic groups were salicylic acid (SA) (34.3%) and benzoyl peroxide (BP) (32.1%). Overall, compliance with acne medications was highest in white versus black (57.0±32.4 vs 42.7±33.5 days, P>0.05), Hispanic (57.0±32.4 vs 43.2±32.9 days, P>0.05), and Asian/other (57.0±32.4 vs 46.9±37.2 days, P>0.05) subjects. Most subjects expected OTC (73.7%) and prescription (74.7%) treatments to work quickly. Fewer than half of the subjects were satisfied with OTC treatment (BP, 47.0%; SA, 43.0%), often due to skin dryness (BP, 26.3%; SA, 44.3%) and flakiness (BP, 12.3%; SA, 31.1%). No statistically significant differences were observed among racial/ethnic groups in their level of satisfaction with OTC or prescription acne treatments.ConclusionRacial/ethnic differences were observed in acne treatment patterns in adult females, while treatment expectations were similar. Results indicate that treatment patterns and expectations may impact treatment satisfaction and medication compliance.

Incidence of Sexually Transmitted Infections After Human Papillomavirus Vaccination Among Adolescent Females

Human papillomavirus (HPV) vaccination rates among US females remain low, in part because of concerns that HPV vaccination may promote unsafe sexual activity by lowering perceived risks of acquiring a sexually transmitted infection (STI). To study whether HPV vaccination of females is associated with increases in STI rates. Using a large, longitudinal insurance database of females aged 12 to 18 years insured from January 1, 2005, through December 31, 2010, in the United States, we examined whether HPV vaccination was associated with an increase in incident STIs among females who were vaccinated compared with those who were not. We defined STIs as one or more medical claims for any of the following infections in a given quarter: chlamydia, gonorrhea, herpes, human immunodeficiency virus or AIDS, or syphilis. We used difference-in-difference analysis to compare changes in STI rates among HPV-vaccinated females before and after vaccination (index quarter) to changes among age-matched nonvaccinated females before and after the index quarter. We analyzed whether effects varied according to age and prior contraceptive medication use. Rates of STIs. The rates of STIs in the year before vaccination were higher among HPV-vaccinated females (94 of 21 610, 4.3 per 1000) compared with age-matched nonvaccinated females (522 of 186 501, 2.8 per 1000) (adjusted odds ratio, 1.37; 95% CI, 1.09-1.71; P = .007). The rates of STIs increased for the vaccinated (147 of 21 610, 6.8 per 1000) and nonvaccinated (781 of 186 501, 4.2 per 1000) groups in the year after vaccination (adjusted odds ratio, 1.50; 95% CI, 1.25-1.79; P < .001). The difference-in-difference odds ratio was 1.05 (95% CI, 0.80-1.38; P = .74), implying that HPV vaccination was not associated with an increase in STIs relative to growth among nonvaccinated females. Similar associations held among subgroups aged 12 through 14 years and aged 15 through 18 years and among females with contraceptive use in the index quarter. Human papillomavirus vaccination was not associated with increases in STIs in a large cohort of females, suggesting that vaccination is unlikely to promote unsafe sexual activity.

Characterization of metabolic syndrome among diverse Hispanics/Latinos living in the United States: Latent class analysis from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Background/objectivesEmpirical investigation of the adequacy of metabolic syndrome (MetS) diagnostic criteria, and whether meaningful subtypes of MetS exist, is needed among Hispanics/Latinos. MethodsIn 15,825 US Hispanics/Latinos from HCHS/SOL, latent class analysis of MetS components (waist circumference, systolic and diastolic blood pressure, HDL cholesterol, triglycerides, glucose, and antihypertensive, lipid- and glucose-lowering medication use) was used to investigate (1) whether distinct subtypes of MetS could be identified, and how component levels differed between them, and (2) how identified subtypes related to covariates and cardiovascular disease (CVD) prevalence. ResultsTwo latent clusters emerged in both men (n=6317) and women (n=9508): one characterized by relatively healthy mean levels (Non-MetS cluster, 77.1% of men and 67.1% of women) and the other by clinically elevated mean levels (MetS cluster, 22.9% of men and 32.9% of women) across most MetS components. These clusters showed expected associations with covariates and CVD prevalence. Notable results suggest that (1) HDL cholesterol may poorly differentiate between US Hispanics/Latinos with and without MetS (mean=45.4 vs. 44.6mg/dL for men and 51.3 vs. 52.0mg/dL for women in the MetS vs. Non-MetS clusters, respectively) and (2) the NCEP-ATP III 88cm waist circumference cutoff for US females may not optimize diagnosis among Hispanic/Latino women (MetS cluster mean waist circumference=102.5cm). ConclusionsBeyond classification into having MetS or not, additional subtypes of MetS do not clearly emerge in US Hispanics/Latinos. Current diagnostic cutoffs for some components may not optimize MetS identification among this population.

The awarding of PhDs in the United States and Canada: war, the draft and other economic determinants

This article is concerned with the awarding of PhDs in the USA and Canada in the post-WW II period, overall, by gender and major academic discipline. The effects of the explanatory variables lagged by 6 years, to allow for time-to-degree completion, are consistent with the model. Military conscription with educational exemptions and the Vietnam War increased male PhDs in the USA, but, as expected, had no effect for US females or in Canada. This suggests that the war and draft effect for US males were not reflecting other unmeasured North American effects. Government expenditures on research and development enhanced the PhD production, especially for males and in the physical sciences. The cyclical indicator, the adult male unemployment rate, has a weak positive effect for males in both the USA and Canada, suggesting that during the post-WW II period, the positive effect on graduate-level education of the reduced opportunity cost of time due to a recession was stronger than the negative wealth effect of the recession. Other variables the same, there has been an increase over time in the female receipts of the PhD, but there is no such trend for males. While males still receive more PhDs per year than females, the gender gap has decreased over time.

Abstract 278: Risk factors and prevalence of genital HPV infection among adult females in US between 2003-2010: Data from NHANES study

Abstract Background: More than 50% of sexually active individuals are infected with human papilloma viruses (HPV). Patients with high-risk type HPV infection are at risk for developing cervical cancer later in their life. Several social, demographic and behavioral factors are associated with HPV infection. Our study estimates the prevalence of genital HPV infection and explores the risk factors associated with HPV infection. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) for the years 2003-2010 was used in this study. These surveys included interviews and laboratory measurements. Around 20,000 females aged 18-59 years were included. Data management and statistical analyses were conducted using SAS software 9.3 and SAS callable SUDAAN 11.0.1. Results: The weighted prevalence of HPV infection was 42.9%. Black females had the highest prevalence of HPV infection (60.2%). In a univariate analysis, smoking, drug use, insurance status, age at first sexual contact, number of sexual partners, condom use, and sexual orientation were all associated with HPV infection. In a multivariate analysis, after adjusting for other factors (e.g. country of birth, routine places for healthcare) age, race, level of education, being in a married relation, number of sexual partners and condom use were all significant factors affecting the risk of HPV infection. Age at first sexual encounter and sexual orientation were found to be no longer significant. Non-Hispanic (NH) blacks are 1.73 times more likely to get HPV as compared to NH whites. Age is negatively associated with the risk of HPV infection, except for a second peak between 45-49 years. Participants with only high school degree are at a 30% increased risk of HPV infection compared to college-educated women. Never married (OR=1.89) or divorced or separated (OR=2.4) women have an increased risk of being infected with HPV. HPV infection is 3.7 times more likely for women who have had &amp;gt;11 partners as compared to women with 0-1 partners. Women who have sex without a condom half the time are at a 47% increased risk for contracting HPV as compared to women who have sex with a condom at all times. Conclusions: We estimate that 42.9% of females aged 18-59 years have genital HPV infection. There is a compelling need to implement measures to prevent further HPV infections. Health education and promotion should focus on limiting the number of sexual partners and encouraging safe sexual practices including the use of condoms. Vaccinating females against HPV at an early age will not only help reduce the rate of infection but also prevent cervical cancer development in the future. It will be necessary to continue monitoring the prevalence of HPV in the general population to provide basis for intervention through vaccination as well as by promoting healthy behaviors in the target population, policy changes and resource allocation. Citation Format: Srinivas S. Devarakonda, Amarendra Neppalli, Lihong Liu, Ellen Friday, Runhua Shi. Risk factors and prevalence of genital HPV infection among adult females in US between 2003-2010: Data from NHANES study. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 278. doi:10.1158/1538-7445.AM2014-278

Severe and moderate haemophilia A and B in US females

Haemophilia A and B are rare X-lined hemorrhagic disorders that typically affect men. Women are usually asymptomatic carriers, but may be symptomatic and, rarely, also express severe (factor VIII (FVIII) or factor IX (FIX) <0.01 U mL(-1)) or moderately severe (FVIII/FIX 0.01-0.05 U mL(-1)) phenotypes. However, data on clinical manifestations, genotype and the psychosocial ramifications of illness in severely affected females remain anecdotal. A national multi-centre retrospective study was conducted to collect a comprehensive data set on affected US girls and women, and to compare clinical observations to previously published information on haemophilic males of comparable severity and mildly affected haemophilic females. Twenty-two severe/moderate haemophilia A/B subjects were characterized with respect to clinical manifestations and disease complications; genetic determinants of phenotypic severity; and health-related quality of life (HR-QoL). Clinical data were compared as previously indicated. Female patients were older than male patients at diagnosis, but similarly experienced joint haemorrhage, disease- and treatment-related complications and access to treatment. Gynaecological and obstetrical bleeding was unexpectedly infrequent. F8 or F9 mutations, accompanied by extremely skewed X-chromosome inactivation pattern (XIP), were primary determinants of severity. HR-QoL was diminished by arthropathy and viral infection. Using systematic case verification of participants in a national surveillance registry, this study elucidated the genetics, clinical phenotype and quality of life issues in female patients with severe/moderate haemophilia. An ongoing international case-controlled study will further evaluate these observations. Novel mechanistic questions are raised about the relationship between XIP and both age and tissue-specific FVIII and FIX expression.

Lifecycle-consistent female labor supply with nonlinear taxes: evidence from unobserved effects panel data models with censoring, selection and endogeneity

This paper uses the Panel Study of Income Dynamics (PSID) from 1979 to 2007 to estimate within-period lifecycle-consistent labor supply elasticities of US females in a two-stage budgeting framework. The paper combines a variety of econometric approaches to estimate unobserved effects panel data models with censoring, selection and endogeneity. The paper finds evidence of substantial upward bias in estimated wage elasticities from pooled panel models which do not account for unobserved effects, as fixed effects and correlated random effects (CRE) specifications yield smaller elasticities. Estimates are also somewhat sensitive to using a lifecycle-consistent specification versus a standard static model. The lifecycle-consistent wage elasticity from a CRE model with instrumental variables is 0.56 on the extensive margin and 0.31 on the intensive margin for an overall wage elasticity of 0.87. The standard static model, on the other hand, yields a wage elasticity of 0.46 on the extensive margin and 0.13 on the intensive margin for an overall elasticity of 0.59.

Age of thelarche and menarche in contemporary US females: a cross-sectional analysis.

A recent secular trend towards earlier thelarche has been suggested. The aim of this study is to examine normative ages of thelarche and menarche in contemporary US females. Trained physicians documented Tanner breast stage by observation in a cross-sectional cohort. Age of menarche was self-reported. The subjects were healthy female children and adolescents. The mean age of thelarche was determined by probit analysis and the mean age of menarche was determined by using a normal time-to-event model. Mean age of thelarche was 9.7 years among 610 females aged 3.0-17.9 years (70% non-Hispanic Caucasian (NHC), 14% African-Americans, 7% Hispanic, 9% "other"). The mean age of menarche was 12.8 years for NHC, with African-Americans having menarche 0.6 years earlier. Thelarche occurred earlier than recently reported, while age of menarche remained unchanged, this supported a persistent secular trend towards earlier thelarche but stable age of menarche. This suggests that the observed thelarche is gonadotropin-independent or the tempo of pubertal advancement has slowed.

Prevalence of Anogenital Warts Among Participants in Private Health Plans in the United States, 2003–2010: Potential Impact of Human Papillomavirus Vaccination

We estimated anogenital wart prevalence from 2003 to 2010 by gender and age group in a large US cohort with private insurance to detect potential decreases among people most likely to be affected by human papillomavirus (HPV) vaccination. We restricted health care claims to those from individuals aged 10 to 39 years with continuous insurance within a given year. We derived anogenital wart diagnoses from a diagnosis of condyloma acuminata, or either a less specific viral wart diagnosis or genital wart medication combined with either a benign anogenital neoplasm or destruction or excision of a noncervical anogenital lesion. Prevalence increased slightly in 2003 to 2006, then significantly declined in 2007 to 2010 among girls aged 15 to 19 years; increased in 2003 to 2007, remained level through 2009, and declined in 2010 among women aged 20 to 24 years; and increased through 2009 but not in 2010 for women aged 25 to 39 years. For males aged 15 to 39 years, prevalence for each 5-year age group increased in 2003 to 2009, but no increases were observed for 2010. These data indicate reductions in anogenital warts among US females aged 15 to 24 years, the age group most likely to be affected by introduction of the HPV vaccine.

Improving the accuracy of prolapse and incontinence procedure epidemiology by utilizing both inpatient and outpatient data

The epidemiologic description of pelvic organ prolapse (POP) and stress urinary incontinence (SUI) procedures is documented in several large studies using national database cohorts. These studies, however, may underestimate the number of procedures performed because they only capture procedures performed in either the inpatient or outpatient settings alone. We present a complete annual description of all inpatient and outpatient surgeries for POP and SUI in California. We reviewed a record of all inpatient and outpatient POP and SUI surgeries performed in California in 2008 using data from the Office of Statewide Health Planning (OSHPD). In 2008, 20,004 and 20,330 women in California underwent POP and SUI procedures, respectively. Of these, 3,134 (15.6%) and 9,016 (44.3%) were performed in an outpatient setting. The age-adjusted rates of POP and SUI were 1.20 and 1.20 per 1,000 US females, respectively. This correlates to 186,000 POP and 186,000 SUI procedures per year nationally. Vaginal apical suspensions were more common in those undergoing surgery as an inpatient (45.1 vs 19.4%). The use of mesh to augment prolapse repairs was similar (22.3% inpatient vs 19.3% outpatient). SUI procedures performed in the outpatient setting were more likely to be performed as stand-alone procedures (82.9 vs 18.8%, respectively). In California, 16% of POP and 44% of SUI procedures were performed in an outpatient surgical setting in 2008. Epidemiologic studies of POP and SUI should account for the fact that a substantial number of repairs are performed in the outpatient setting in order to achieve accuracy.

The effect of atmospheric particulate matter on survival of breast cancer among US females

Short-term effects of ambient particulate matter (PM) on cardiopulmonary morbidity and mortality have been consistently documented. However, no study has investigated its long-term effects on breast cancer survival. We selected all female breast cancer cases (n = 255,128) available in the California Surveillance Epidemiology and End Results cancer data. These cases were linked to 1999-2009 California county-level PM daily monitoring data. We examined the effect of PM on breast cancer survival. Results from Kaplan-Meier survival analysis show that female breast cancer cases living in areas with higher levels of PM10 and PM2.5 had a significant shorter survival than those living in areas with lower exposures (p < 0.0001). The results from marginal cox proportional hazards models suggest that exposure to higher PM10 (HR 1.13, 95 % CI 1.02-1.25, per 10 μg/m(3)) or PM2.5 (HR 1.86, 95 % CI 1.12-3.10, per 5 μg/m(3)) was significantly associated with early mortality among female breast cancer cases after adjusting for individual-level covariates such as demographic factors, cancer stage and year diagnosed, and county-level covariates such as socioeconomic status and accessibility to medical resources. Interactions between cancer stage and PM were also observed; the effect of PM on survival was more pronounced among individuals diagnosed with early stage cancers. This study suggests that exposure to high levels of PM may have deleterious effects on the length of survival from breast cancer, particularly among women diagnosed with early stage cancers. The findings from this study warrant further investigation.

Attention-deficit/hyperactivity disorder and obesity in US males and females, age 8-15 years: National Health and Nutrition Examination Survey 2001-2004.

Youth with ADHD may be at increased risk for obesity. Medications used to treat ADHD can affect weight. Few studies have investigated possible gender differences in associations between ADHD and obesity. Nationally representative of US youth aged 8-15 years. Height and weight were measured, and ADHD assessed by structured diagnostic interview and parent report. Associations between ADHD and obesity are reported for males and females to enable gender comparisons. To investigate how associations between attention-deficit/hyperactivity disorder (ADHD) and obesity differ by gender and medication use in a nationally representative sample of US youth in which height and weight were measured. Youth age 8-15 (n = 3050) studied in the National Health and Nutrition Examination Survey 2001-2004. Obesity was defined as ≥95th percentile of US body mass index-for-age reference. ADHD was determined by asking parents if child had been diagnosed and using the Diagnostic Interview Schedule for Children IV. Gender-stratified multivariable logistic regression was used to estimate odds of obesity for youth with ADHD (medicated and unmedicated) relative to youth without ADHD. Males with ADHD who were medicated had lower odds of obesity compared to males without ADHD (adjusted odds ratio [OR] = 0.42, 95% confidence interval [CI] = 0.23-0.78). Unmedicated males with ADHD were as likely as males without ADHD to be obese (adjusted OR = 1.02, 95% CI = 0.43-2.42). The odds of obesity for females taking medication for ADHD did not differ statistically from those of females without ADHD (adjusted OR = 1.21, 95% CI = 0.52-2.81). Females with ADHD not taking medication had odds of obesity 1.54 times those of females without ADHD; however, the 95% CI (0.79-2.98) was wide and not statistically significant at α = 0.05. Associations between ADHD and obesity are influenced by treatment of ADHD with medication and may differ by gender. Youth with ADHD who are not treated with medication are as or more likely than youth without ADHD to be obese.

Depot Medroxyprogesterone Acetate Use and Periodontal Health in 15‐ to 44‐Year‐Old US Females

It has been suggested that progestins may have an inflammatory component and/or increase in prostaglandin synthesis. Thus, extended progestin use may be associated with higher risk of periodontal diseases. This study investigates the association between depot medroxyprogesterone acetate (DMPA) injectable contraception and the prevalence of periodontal diseases among US premenopausal females. Data for this cross-sectional analysis comes from the 1999 to 2004 National Health and Nutrition Examination Surveys. This analysis includes 4,460 US females (15 to 44 years of age) with complete DMPA usage and periodontal status data. Current and past DMPA use was 4.1% and 12.0%, respectively. The prevalence of gingivitis was 53.9% for females who reported having used DMPA compared with 46.1% for DMPA never-users. Females taking DMPA were more likely to be young, single, and non-white, have a history of smoking, have lower levels of education and income, and have ≥1 live births and were less likely to visit the dentist. Using logistic regression, DMPA use was associated with an increased risk of gingivitis (odds ratio [OR] =1.7; 95% confidence interval [CI] = 1.09 to 1.67) and periodontitis (DMPA, OR = 1.49; 95% CI = 1.01 to 2.22) after adjusting for age, race, education, poverty income ratio, dental care use, and smoking status. A significant interaction between smoking status and DMPA use was also found (P = 0.029). This study suggests that DMPA use may be associated with periodontal diseases. Additional investigation is warranted as a result of the disproportionate usage of DMPA among low-income populations who are at an increased risk for poor dental health.

Relationship between physical activity, physical performance, and iron status in adult women

Iron deficiency affects approximately 16% of US females 18-45 years old. Iron is a key component of heme-containing proteins, which are essential for oxygen transport throughout the body. With low iron levels, performance and intense physical activity may be compromised. Thus, the purpose of this study was to examine the relationship between iron status, physical performance, and physical activity in 18- to 45-year-old females. Participants (N = 109) were screened for iron status using a venous blood sample, had their height and mass measured, and self-reported their physical activity level. The screening was used to match iron-depleted nonanemic females (hemoglobin, Hgb > 120 g·L(-1); serum ferritin, sFer < 20 µg·L(-1)) to females with normal iron levels. After participant matching, they had their body composition measured, performed three cycle ergometer tests (maximal, endurance, and efficiency), and wore an ActiGraph GT1M accelerometer for five consecutive days, except when sleeping or during water activities. The final sample consisted of 25 iron-depleted participants and 24 with normal iron levels. Key findings were as follows: (i) after controlling for fat-free mass and vigorous physical activity, iron-depleted females had a significantly lower [Formula: see text]O(2) at ventilatory threshold compared with those with normal iron levels (P < 0.05); and (ii) after controlling for age, iron-depleted females spent significantly more time in sedentary behaviors and significantly less time in light physical activity than those with normal iron levels (P < 0.05). The increased sedentary time in iron-depleted females may contribute to excess mass gain over time; however, further investigation is needed to confirm these results.

Abstract SY12-01: HPV vaccines: The opportunity to prevent multiple cancers

Abstract SY12-01: HPV vaccines: The opportunity to prevent multiple cancers