Abstract: Objectives : The aim of the study was to assess MR sialography and Ultrasonography as objective tools to examine salivary glands in patients with xerostomia. Methods : In this Cross-sectional descriptive study,MR sialography using salivary secretion stimulation was performed in 16 patients (with the chief complaint of xerostomia) and 11 healthy volunteers.Visibility of the main duct and ductal branches were evaluated before and after stimulation in axial and oblique sagittal plans, and were classified in to three grades (poor,fair & good). Patients and volunteers were also examined by ultrasonography;their parenchymal homogeneity of the salivary glands was graded from 0 to 5 and their echogenicity was divided to three levels:hypoecho, isoecho and hyperecho. Size of the salivary glands was also measured.Dependent T-test and independent T-test ,Spearman and Chi-square analysis were performed to analyze the results. Results : In this study the results showed no significant difference in the visibility of salivary glands ducts before and after salivary secretion stimulation in healthy volunteers.In the patients group, however, significant difference was seen in the visibility of salivary glands ducts after stimulation in sagittal planes of right and left parotid glands(P-Value=0.033)as well as left submandibular glands(P-Value=0.035). No significant difference in the visibility of salivary glands ducts was observed between healthy volunteers and patients,except in sagittal plan of left parotid glands (P-Value=0.004).In addition, there was no significant difference in parenchymal characteristics and size of salivary glands in ultrasonography results in the two groups. No Significant correlation could be established between MR Sialography and Ultrasonography findings. Conclusion : Achieving no significant difference in imaging results between patients and volunteers suggests that MR sialographic images and US features may not serve as suitable diagnostic criteria in patients with xerostomia. Key words : Ultrasonography - MR Sialography -Xerostomia -Salivary Glands