INTRODUCTION AND OBJECTIVE: To compare 3 contractility parameter indices, projected isovolumetric pressure (PIP-BCI), PIP1, and k from the VBN mathematical model, for women referred for evaluation of various lower urinary tract symptoms (LUTS) in relationship to age, presenting complaint and urodynamic diagnosis. METHODS: Urodynamic tracings of non-neurologic women referred for investigation of LUTS were retrospectively analyzed. All patients were evaluated with medical history, review of medications, bladder diary for at least 48h, physical examination and dipstick analysis. Each urodynamic session was performed using a urodynamic unit from Laborie (Mississauga Canada) and carried out according to the International Continence Society Good Urodynamic Practices.Bladder was filled with saline at room-temperature at a medium filling rate of 50 mL/min. Filling cystometrogram was obtained via a triple lumen urethral catheter 7F allowing for urethral pressure recording followed by an intubated flow (IF) During IF, pdet.Qmax and Qmax were measured. Post void residual volumes (PVR) were measured by Bladder-scan. The initial bladder volume or Vini was calculated by adding the voided volume to the PVR. Three age groups pre, peri and post-menopausal were compared. Excluded were women with UTI, stage >2 prolapse, no voiding during the study, or low volume voided. RESULTS: 449 urodynamic tracings met study criteria. Main complaint was incontinence, with a second group (Other) of 95 women with non-incontinence LUTS. PIP-BCI, PIP1 and k decreased significantly with ageing in each sub-group.PIP-BCI was significantly different between MUI and Other (p=.0259) while PIP1 was significantly higher in UUI vs. Other (p=.0161) and k in UUI vs. SUI (p=.0107), MUI (p=.0010) and Other (p=.0224).Low value of PIP-BCI for bladder outlet obstruction vs. detrusor overactivity while PIP1 and k values were high and similar for these two diagnoses and a high value of PIP-BCI for detrusor overactivity with impaired contractility close to the value for bladder outlet obstruction while PIP1 and k were low. CONCLUSIONS: Evaluation of detrusor contractility in women is easily obtained using indices PIP-BCI and PIP1 or using the VBN nomogram giving parameter k. PIP1 and parameter k produced comparable and consistent results with the urodynamic diagnosis while PIP-BCI leads to inconsistencies. Source of Funding: none