You have accessJournal of UrologyUrodynamics/Incontinence/Female Urology: Neurogenic Voiding Dysfunction1 Apr 20101003 DEVELOPMENT OF BLADDER DYSFUNCTION IN A RAT MODEL OF DOPAMINERGIC BRAIN LESION Roberto Soler, Claudius Füllhase, Cesar Santos, and Karl-Erik Andersson Roberto SolerRoberto Soler More articles by this author , Claudius FüllhaseClaudius Füllhase More articles by this author , Cesar SantosCesar Santos More articles by this author , and Karl-Erik AnderssonKarl-Erik Andersson More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2010.02.2017AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Parkinson's disease (PD) is one of the most common neurological disorders causing lower urinary tract dysfunction. We evaluated the temporal development of bladder dysfunction in rat PD model where urodynamic changes following nigrostriatal injury were induced by unilateral injection of 6-hydroxydopamine (6-OHDA), a dopaminergic neurotoxin, into the medial forebrain bundle (MFB). METHODS Female Sprague-Dawley rats underwent a unilateral stereotaxic injection of 8ìg 6-OHDA or vehicle (sham group) into the MFB. Cystometry was performed in conscious animals at 3, 14 and 28 days after the injury. Aged-matched unlesioned rats were used as healthy controls. RESULTS Three days after lesion 6-OHDA-rats showed higher threshold (TP), maximum pressures (MP) and spontaneous activity (SA) compared to healthy controls. Sham animals exhibited higher TP. After 14 days 6-OHDA rats had also higher micturition frequency, decreased bladder capacity, micturition volume and bladder compliance (Bcom) compared to sham and healthy controls. Sham animals showed lower Bcom and higher MP and SA. After 28 days, 6-OHDA-rats exhibited the same changes as those in 14 days, while sham-operated animals showed parameters similar to those in healthy controls. CONCLUSIONS These findings suggest that 6-OHDA lesion of the MFB causes bladder dysfunction already after 3 days. A pattern of detrusor overactivity was more clearly defined 14 days after the injection and persisted for 28 days. Changes in micturition pressures, which may represent a possible outlet obstruction, were seen in 6-OHDA-lesioned animals throughout the whole follow-up and in early endpoints in the sham animals. Cystometry may be a useful tool to study the pathophysiology of bladder dysfunction in PD, and urodynamic parameters may possibly be used to evaluate the effects of therapeutic interventions. Winston Salem, NC© 2010 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 183Issue 4SApril 2010Page: e390 Advertisement Copyright & Permissions© 2010 by American Urological Association Education and Research, Inc.MetricsAuthor Information Roberto Soler More articles by this author Claudius Füllhase More articles by this author Cesar Santos More articles by this author Karl-Erik Andersson More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...