Background: Chronic kidney disease (CKD) is a globalpriority public health concern that accounts forsignificant morbidity and mortality. Unusual occurrence of CKD was reported from Cuttack district ofOdisha. We aim to establish a CKD surveillance system in Cuttack district to estimate the burden of diseaseand help decision-makers through future epidemiological assessments.Method: We focused on CKD patients enrolled in the Narsingpur community health clinics and attendingthe clinics from January to June 2016. We defined a suspected CKD as patientpresenting with any symptomsof loss of appetite, fatigue &weakness, change in urine output, swelling of feet & ankles and blood in urine.A confirmed CKD was defined as a CKD suspect with elevated Serum creatinine (>1.5 mg/dL) and SerumUrea (>40 mg/dL).Besides, we collected relevant data on demography, clinical, laboratory, occupational andfamily history of patients.Results: The CKDsurveillance presented over 320 suspected CKD cases, of which 35 cases were laboratoryconfirmed. The median age was 57 years ranging from 35 -75 years (Mean +SD= 56+9.1), 71% of cases weremales and agriculture was the commonest occupation. Laboratory finding shows fasting blood glucose of147.4 mg/dl (Range 84-249), Serum Creatinine 3.59 mg/dl (Range 2.2-7.9), Serum Urea 76.6 mg/dl (Range14.1-137), Urine Creatinine 6.0 mg/24 hrs (Range, 4.4-7.3) and Urine Albumin 7.6 mg/dl (Range 7.2-8.4).The majority of patients (57%, 20/35) were in CKD stage 3 (GFR, between 60 and 89 ml/min/1.73m2).Conclusion:The CKD surveillance system supported CKD patient’s analysis by age, gender, geographicaldistribution and socio-demographic profile. Further, the analysis involved analysing patient’s clinicalcharacteristics, CKD staging, associated co-morbidities and treatment modalities.The surveillancesystem established a scientific platform for primary prevention, early detection, and treatment strategiesimplementation. The platform eventuallyhelped the decision-makers increase awareness, decrease CKDmorbidity & mortality throughmore efficient resource utilization.