Urinary Excretion Of Oxalic Acid Research Articles

The urinary excretion of oxalic acid in urolithiasis. I. The estimation of urinary oxalic acid

It was supported that Yarbro & Simpson's method (1956) was most reliable to estimate the urinary excretion of oxalic acid at present. We measured the urinary oxalic acid excretion in 8 normal adults, 13 patients with simple calculus and 6 patients with multiple or staghorn calculi of upper urinary tracts. All calculi contained the oxalate, certified with infrared spectra.The following conclusions resulted:1) Urinary oxalic acid excretion in normal adults was 12.6 to 59.0mg per day.2) It was within normal range in the patients with simple calculus (11.7 to 60.5mg per day).3) The slightly increased excretion of urinary oxalic acid was found in the patients with multiple or staghorn calculi (28.3 to 62.1mg per day).4) There was no correlation between the urinary excretion of oxalic acid and the contents of oxalate in calculi.

URINARY OXALIC ACID EXCRETION BY MAN FOLLOWING INGESTION OF LARGE AMOUNTS OF ASCORBIC ACID

Recently, large amounts of ascorbic acid are used for the treatments of various diseases, so that the investigation on the urinary excretion of oxalic acid, which is one of the metabolites of ascorbic acid, was carried out in man following the administration of large amounts of the vitamin and the following findings were obtained.1. No significant increase in urinary oxalic acid was observed following the ingestion of large amounts (1-2g) of ascorbic acid for a long period (90-180 days).2. After ingestion of large amounts of ascorbic acid, it was eliminated in urine mainly in the reduced form of the vitamin and little was determined as diketogulonic acid, the precursor of oxalic acid.

The fluorimetric determination of oxalic acid in blood and other biological materials.

1. Oxalic acid is separated from interfering substances by extraction with tri-n-butyl phosphate followed by co-precipitation with calcium sulphate. The precipitated oxalic acid is then reduced to glyoxylic acid, which is coupled with resorcinol to form a coloured fluorescent complex. 2. The spectrofluorometric method described is sensitive and highly specific, the minimum detectable amount of oxalic acid being 0.9mumole under the recommended conditions. 3. The concentration of oxalic acid in blood from 15 normal adults was 200-320mug./100ml. For serum the range was 135-280mug./100ml. The urinary excretion of oxalic acid by 60 normal adults on a normal diet was 9.0-28.5mg./24hr.

Effect of the Administration of Isoniazid and a Diet Low in Vitamin B6 on Urinary Excretion of Oxalic Acid

Effect of the Administration of Isoniazid and a Diet Low in Vitamin B6 on Urinary Excretion of Oxalic Acid

Effect of Pyridoxine Administration on the Urinary Excretion of Oxalic Acid, Pyridoxine, and Related Compounds in Mongoloids and Nonmongoloids

The excretion of various metabolites by mongoloid and nonmongoloid mentally deficient patients has been studied prior to and following the oral administration of pyridoxine and folic acid. The excretion of oxalic acid by both groups was markedly reduced by pyridoxine administration although the subjects had been receiving a diet apparently adequate in vitamin B6. Following pyridoxine administration, mongoloids excreted more pyridoxic acid and less vitamin B6 than did nonmongoloids. No significant differences in folic acid excretion were observed in the two groups studied.

Urinary oxalate excretion by man following ascorbic acid ingestion.

SummaryAn investigation was conducted to determine the urinary oxalate excretion of normal males on their regular diet, and to determine to what extent extra-dietary ascorbic acid would increase this excretion. The mean 24 hour urinary oxalic acid excretion of 51 healthy adult males on their regular diets was 38.3 ± 1.7 mg. The 24 hour excretion of any individual was remarkably constant over a three week period. The daily ingestion of 4 or more g of ascorbic acid increased urinary excretion of oxalic acid; whereas the daily ingestion of less than 4 g of ascorbic acid produced no significant increase in oxalate excretion.