You have accessJournal of UrologyBenign Prostatic Hyperplasia: Surgical Therapy and New Technology I1 Apr 20121983 URETHRAL SPARING HISTOTRIPSY OF THE PROSTATE IN A CANINE MODEL George R. Schade, Timothy L. Hall, and William W. Roberts George R. SchadeGeorge R. Schade Ann Arbor, MI More articles by this author , Timothy L. HallTimothy L. Hall Ann Arbor, MI More articles by this author , and William W. RobertsWilliam W. Roberts Ann Arbor, MI More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.2143AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Histotripsy is a non-invasive ablative focused ultrasound technology that results in a TURP like defect in a canine model of benign prostatic hypertrophy. However, the necessity of urethral treatment during histotripsy to achieve tissue debulking is unclear. We evaluated the feasibility and healing response to urethral sparing prostate histotripsy. METHODS Histotripsy was performed on 10 mongrel canines using a focused 1 MHz piezoelectric ultrasound transducer targeting the prostatic parenchyma while avoiding the urethra. Cystoscopy was performed immediately post-op (POD0) and on POD3, 7, 14, 28 and 56 to evaluate for evidence of urethral disruption. Ultrasound surveillance was performed preop and at POD7, 14, 28, and 56. Labs, including white blood cell count (WBC) and serum CRP, were checked at the time of surveillance cystoscopy in chronic subjects to monitor for systemic inflammatory response. Four, two, and four subjects were euthanized acutely, at 1 week, and at 8 weeks, respectively, with confirmatory histology. RESULTS Bilateral treatment was possible in 8/10 subjects while left side only treatment was performed in 2/10. Urethral treatment effect was seen in only 1 subject on POD0 post-treatment cystoscopy, which evolved to urethral disintegration by POD14. An additional treatment developed urethral fenestrations at POD28 despite normal appearing cystoscopy for the 1st week. Among 8-week subjects there was a small reduction in volume (20.4 cc at 8 weeks vs. 23.3 cc preop). Lab studies revealed a small transient increase in mean preop WBC compared to POD3 (7.1 vs. 11.7 K/μL) that resolved by POD7. CRP peaked on POD3 and returned to baseline by POD56 (2.3 (preop) vs. 30.3 (POD3) vs. 1.8 (POD56) μg/mL). At 8 weeks, intact treatment cavities contained simple fluid with minimal cellular debris and were completely urothelialized with minimal focal inflammation on histology (see Figure). CONCLUSIONS Urethral sparing histotripsy of the prostate is feasible, resulting in volume reduction with treated volumes appearing as cavities containing simple fluid at 8 weeks. Further studies are needed in humans to evaluate the clinical utility and symptomatic response of urethral sparing. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e800 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information George R. Schade Ann Arbor, MI More articles by this author Timothy L. Hall Ann Arbor, MI More articles by this author William W. Roberts Ann Arbor, MI More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...
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