Recently we reviewed a series of 600 case histories in the female, our object at that time being to evaluate all etiologic factors that were directly or indirectly responsible for bladder symptoms. We were impressed with the unusually large number of urethral caruncles and made them the subject of a special report recently published. Probably as a result of that publication we were asked to continue our studies of the remaining cases of that series and report our findings in only those cases in which, although bladder symptoms were present, there was an absence of pyuria. To conform with this request we rechecked the histories of that series and eliminated 86 cases in which upper urinary tract involvement and obvious bladder disease such as tumors and stones were the basic etiologic factors in the production of bladder symptoms. This left 312 cases, in 160 of which pyuria and urinary tract