This paper presents an integrated Monitoring and Evaluation (M&E) framework, an all-encompassing approach suitable for European cities and regions aiming to monitor and evaluate the implementation and results of sustainable urban development strategies or projects related to urban planning, transport planning, or urban energy management. The framework features a co-created and co-implemented reflexive and adaptive method tailored specifically for strategies or projects that introduce innovative elements from contemporary research and innovation in science and technology, such as net-zero development, systemic solutions for cities, or integrated urban mobility and planning. The approach to designing and implementing the M&E framework was realized through a six-phase process: (i) development of the M&E framework, (ii) tailoring indicators to each region’s specificities, (iii) developing data collection questionnaires and a reporting database, (iv) collecting the data, (v) populating the database, and (vi) writing the final report. The framework was tested and enhanced with four European regional authorities over a 19-month period, enabling them to address their so-called 'policy dilemmas,' defined as the challenges they face in balancing societal and inclusivity objectives with economic and innovation goals. This framework is designed for replication in future sustainable urban development strategies or projects with similar societal, ecological, and innovation objectives.