Background: Childhood obesity and hypertension are on the rise. Obesity leads to many complications like type 2 diabetes mellitus, polycystic ovaries, cancers, etc. Diagnosis of obesity is by various anthropometric indices, some not so accurate. Hence, this warrants intensive studies of these indices in relation with obesity and hypertension. This study was undertaken prevalence of obesity and hypertension in adolescents and its relationship with anthropometric indices and to study the waist-circumference-by-height ratio and its relationship with obesity.Methods: This prospective, cross-sectional, observational study was conducted in Department of Pediatrics, Dr. Panjabrao Deshmukh Medical College and Hospital, Amravati, Maharashtra, India and data was collected from urban secondary schools of Amravati from 450 adolescents between ages 12-17years, selected randomly, with the help of preformed questionnaires. Anthropometric measurements were taken to calculate BMI, waist circumference and skin- fold thickness and blood pressure taken. Data was analyzed using WHO and teacher-made scales and statistically using contingency coefficient.Results: Out of 450, prevalence of overweight was 19.1% (86) and obesity was 10.7% (48). Out of 48 obese, 32 were males. Prevalence of obesity was significantly higher among adolescents who had physical activity of ≤3hours/week and who watch TV and/or use computer for >2hours/day. Out of 194 adolescents who had normal BMI, 20 (26.3%) had central obesity. 29 (6.4%) had hypertension, 11 (37.9%) of them were obese.Conclusions: The prevalence of primary hypertension among adolescents has increased, largely due to the childhood obesity epidemic and thus, steps should be taken to curb both these demons at the earliest. Waist-circumference-to-height ratio should be used more than other indices as it detects central obesity and related cardio-metabolic risk among normal-weighted children.