This research examines the utility of combined crash modification factors (CMFs) in minimizing crash severity at urban roundabouts. Conventional CMFs typically assess the influence of singular interventions on road safety. However, traffic dynamics and the interactions among multiple safety measures necessitate a more comprehensive strategy. This study introduces a novel methodology for developing integrated CMFs that accounts for the interactive effects of multiple safety measures, providing a comprehensive understanding of their collective impact on road safety. The investigation utilized data from 16 urban roundabouts in Amman, Jordan, from 2015 to 2021. Regression models have been employed to develop individual and combined CMFs for various geometric and traffic characteristics, such as entry and exit widths, speed limits, and weaving patterns. Key findings indicate that interventions, such as reducing speed limits, modifying entry and exit widths, and adjusting weaving lengths, significantly improve safety. The analysis identifies hazardous roundabouts and proposes effective single and combined treatments to mitigate crash risks. This study highlights the importance of considering multiple treatments simultaneously to improve the predictive accuracy of safety assessments and supports the development of more effective road safety strategies tailored to specific crash types and severities. The approach demonstrates a significant potential to enhance road safety analysis and decision-making, ultimately contributing to safer road environments.