Changing land use/land cover (LULC) and climate substantially affect the hydrological components of a watershed. This study explored the future impact of the hydrological responses due to the changing LULC and climate on the Big Creek Lake watershed in Alabama, USA, from 2021 to 2050 using the Soil and Water Assessment Tool (SWAT). Five climate model datasets were used under the moderate scenario (Representative Concentrative Pathways 4.5) and the extreme scenario (Representative Concentrative Pathways 8.5), and the datasets were downscaled and bias-corrected. In addition, changing the LULC of five categories was predicted by Cellular Automata Markov (CA- Markov). With these data combined with the elevation (Digital Elevation Model), soils, and weather data, the SWAT model was calibrated and validated for the studied watershed to quantify how climate change will affect streamflow, nitrogen, and phosphorus. Our results indicate streamflow will increase due to the 50-acre increase in urban LULC. As streamflow increases, the percolation, surface runoff, lateral flow, groundwater flow, and water yield will also increase because the streamflow impacts these hydrological components. Moreover, the increase rate in streamflow is the same for all the components for January, February, and March. Therefore, there is a strong correlation between these months. On the contrary, evaporation will be high in May, June, and July because of the increasing temperature and streamflow. However, the changes in the water hydrological parameters and total nitrogen and phosphorus will be more intense in RCP8.5 than in RCP4.5.