The aim of this study was to describe the perception and satisfaction of mitigation measures along the construction site of a major urban highway, and to quantify the relationship between mitigation measures and noise annoyance. A total of 1,409 participants were included in a first socio-acoustic survey in 2018, and 609 in a second survey in 2020. Residents were generally satisfied with most of mitigation measures, although a reduction in their perceived effectiveness was observed in the 2020 survey. The perception of mitigation measures explained between 2.9 and 6.5% of the variance in construction noise annoyance. Traffic management, site surveillance and temporary noise barriers were the most important variables in the statistical models. While some measures are used only by a small proportion of the target population, our results show that implementing comprehensive mitigation measures can help to reduce construction noise annoyance.