Vegetables and cereals, besides health benefits, are of significant socio-economic importance in Ghana, because, the whole production process provides employment for both rural and urban dwellers. Unfortunately, the high prevalence of pests (weeds inclusive) and disease complexes, associated with them, inflict significant economic damage on field and storage, if not properly managed. This review purposed to document challenges from pesticide use and suggest perspective recommendations for mitigation. Information was sourced from published journal articles, technical and annual reports (Research Extension Farmer Linkage Committee (RELC), Environmental Protection Agency (EPA, Ghana), and Institutions), the authors’ observations and personal communication with farmers, agricultural extension agents and other experts. The review analysis indicated over 80% of farmers use pesticides, particularly on high-value cash vegetable and cereal crops; and also to alleviate human labour constraints. Challenges such as pesticide resistance, increasing incidence of existing pests and diseases, or the manifestation of new pests and diseases due to climate change or continuous cropping among others were evident, prompting shifts to increased pesticide use for management and also for desired profit. Highlights on concerns for the insatiable quest for pests and disease control by chemical means, consequently increased reports on dangers of continuous pesticide use on human and public health, the environment and the economy. This research revealed that a minimal understanding of the use and application of pesticides contributed to the non-intended effects on health and the environment. Hopefully, the identified gaps and recommendations if properly addressed by policy would significantly enhance quality production systems for global trade and protect local consumers. State the contribution of this study to scholarship. Keywords: Vegetable Crop Production, Pesticide Use, Contamination, Pesticide Residue, Public Health
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