As a potential replacement for the National Bureau Standards Reactor (NBSR) at the U.S. National Institute of Standards and Technology (NIST), a conceptual design of a new reactor with a horizontally-split core has recently been studied using low-enriched uranium (LEU) silicide dispersion (U3Si2/Al) fuel. In this paper, the neutronics calculations of the proposed NIST reactor with other two low-enriched U-Mo fuels (U-10Mo monolithic fuel and U-7Mo/Al dispersion fuel) were performed, and the results were compared to that of the U3Si2/Al fuel, with the objective of identifying the best fuel candidate for the reactor cycle length and maximum cold neutron production. To make consistent comparisons, fuel inventories for multi-cycle equilibrium cores were produced for each fuel based on a 30 d reactor cycle at 20 MW thermal power. With its very high uranium density, the potential to load more uranium in the core with U-10Mo monolithic fuel was explored with test cases using an alternate fuel management scheme, a higher power level (30 MW), or a longer cycle (45 d). The research results indicate similar neutronics performance characteristics of the three LEU fuel options in the proposed NIST reactor with the same power level. However, the ability to load more fuel in the reactor with the U-10Mo option allows additional flexibility in the reactor design and could lead to other optimizations that maximize cold neutron production.