The concentrations of Hg, Cu, Pb, Zn, Cd, Fe, Mn, Cr and As were measured in groundwaters from the Upper West and Upper East Regions and the Accra Plains of Ghana. Apart from Fe, the trace metal levels for the two Upper Regions were similar. Samples from the Accra Plains had the highest trace metal concentration. However, Hg and As were undetected in all the samples. While the mean Cd, Mn and Cu concentrations for all the 3 study areas fell below the WHO limit, values for Pb and Cr exceeded the WHO limits for drinking water. Iron exceeded the limits in the Upper West Region and the Accra Plains. Overall, the most abundant elements in groundwaters were Zn, Fe and Cr.